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PRDX2 encodes a member of the peroxiredoxin family of antioxidant enzymes, which reduce hydrogen peroxide and alkyl hydroperoxides. Zusätzlich bieten wir Ihnen Peroxiredoxin 2 Antikörper (163) und Peroxiredoxin 2 Kits (54) und viele weitere Produktgruppen zu diesem Protein an.
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Mouse (Murine) Peroxiredoxin 2 Protein expressed in Escherichia coli (E. coli) - ABIN2121834
Zhao, Du, Zhou, Liu, Gu, Long: Differences in Proinflammatory Property of Six Subtypes of Peroxiredoxins and Anti-Inflammatory Effect of Ligustilide in Macrophages. in PLoS ONE 2016
Show all 2 Pubmed References
Human Peroxiredoxin 2 Protein expressed in Wheat germ - ABIN1316151
Desmetz, Bascoul-Mollevi, Rochaix, Lamy, Kramar, Rouanet, Maudelonde, Mangé, Solassol: Identification of a new panel of serum autoantibodies associated with the presence of in situ carcinoma of the breast in younger women. in Clinical cancer research : an official journal of the American Association for Cancer Research 2009
PRX-2 gene can inhibit the phenotypic change of Epidermal Stem Cells differentiating into Sweat Gland Cells and improve the ability to maintain their own specific antigens.
Prx (zeige PRDX6 Proteine) II exhibited more effective molecular chaperone (zeige HSP90AA1 Proteine) activity than Prx (zeige PRDX6 Proteine) I when UCH-L1 (zeige UCHL1 Proteine) was the client. Prx (zeige PRDX6 Proteine) II interacted with UCH-L1 (zeige UCHL1 Proteine) through its C-terminal region to protect UCH-L1 (zeige UCHL1 Proteine) from thermal or oxidative inactivation
The c-Myc (zeige MYC Proteine)/miR (zeige MLXIP Proteine)-200b/PRDX2 loop regulates colorectal cancer (CRC (zeige CALR Proteine)) progression and its disruption enhances tumor metastasis and chemotherapeutic resistance in CRC (zeige CALR Proteine).
Lys191 residue in this exposed C-terminal region of oxidized Prx2 is polyubiquitinated and the ubiquitinated Prx2 is readily degraded in proteasome and autophagy.
Our findings indicate that Prdx2 might have an important role in the regulation of trophoblast proliferation and apoptosis during early pregnancy, and that its expression is mediated by c-Myc (zeige MYC Proteine). Thus, these two proteins may be involved in the pathogenesis of RM and may represent potential therapeutic targets
Data indicate that Prx2 is denitrosylated by Srxn1 (zeige SRX1 Proteine)-mediated, and the two proteins physically bind via disulfide bond formation, providing a structural basis for the enzymatic reaction that requires ATP hydrolysis.
Overexpression of peroxiredoxin 2 and VEGFR2 (zeige KDR Proteine) in pterygium might be involved in the pathogenesis or recurrence of pterygium. The increase of VEGFR2 (zeige KDR Proteine) might be related to the increase of peroxiredoxin 2 in response to excessive reactive oxygen species from ultraviolet exposure.
Knockdown of peroxiredoxin 2 (Prdx2) reduced the self-renewal and sphere formation in colon cancer stem cells (CSCs).
PRDX2 and p-AKT (zeige AKT1 Proteine) protein expression were analyzed by immunohistochemistry technology.
Association and oligomerization of Prx (zeige PRDX6 Proteine) II could take part in recovery and protection of the CK BB enzyme activity from inactivation during heat-induced stress.
our data highlight a novel role of Prx2 (zeige PRRX2 Proteine) in iron homeostasis. Prx2 (zeige PRRX2 Proteine) is a key cytoprotector against IO that is induced either by iron supplementation or due to chronic hemolysis as in beta-thalassemia.
The data indicate that Prx2 (zeige PRRX2 Proteine) is able to interrupt the hypoxia induced vicious cycle involving oxidation-inflammation-autophagy in the pathogenesis of pulmonary hypertension.
one of the antioxidant enzymes, Prdx-2, was abundantly nitrosylated and temporarily reduced in antioxidant activity, causing transient endogenous hydrogen peroxide (H2O2) accumulation and subsequent X-box binding protein-1s/phosphatidylinositol 3-kinase pathway activation.Prdx-2 nitrosylation could be a potent strategy to affect the pluripotent stem cell-derived cardiomyogenesis.
Oxidative stress promotes PRX2 (zeige PRRX2 Proteine) and PRX3 (zeige PRDX3 Proteine) hyperoxidation and attenuates pro-survival signaling in aging chondrocytes.
The ventral signal observed for Prdx2 from early stages colocalized with motor neuron markers Isl1 (zeige ISL1 Proteine)/2 and FoxP1 (zeige FOXP1 Proteine) and strong ventral signal colocalizing with Isl1 (zeige ISL1 Proteine)/2 was observed in all rostrocaudal segments of the spinal cord.
Prx2 (zeige PRRX2 Proteine) glutathionylation is a favorable reaction that can occur in cells under oxidative stress and may have a role in redox signaling. GSH/Grx1 (zeige GRX1 Proteine) provide an alternative mechanism to thioredoxin (zeige TXN Proteine) and thioredoxin reductase for Prx2 (zeige PRRX2 Proteine) recycling.
elevation in hyperoxidized Prxs, notably Prx2 (zeige PRRX2 Proteine) and Prx3 (zeige PRDX3 Proteine), was observed in several organs from SOD1 (zeige SOD1 Proteine)-deficient mice. However, a SOD1 (zeige SOD1 Proteine) deficiency had no impact on the wheel-running activity of the mice
PrxII functions as a protective antioxidant enzyme against collagen-stimulated platelet activation and platelet-dependent thrombosis
Prx I and Prx II appear to have a tight association with the mechanism underlying the protection of ESC stemness in developing teratomas.
results suggest that inactivation of PrxII is important for the stability of FoxO1 (zeige FOXO1 Proteine) protein, which subsequently mediates Foxp3 (zeige FOXP3 Proteine)( ) Treg cell development, thereby attenuating colonic inflammation
This gene encodes a member of the peroxiredoxin family of antioxidant enzymes, which reduce hydrogen peroxide and alkyl hydroperoxides. The encoded protein plays an antioxidant protective role in cells, and it may contribute to the antiviral activity of CD8(+) T-cells. The crystal structure of this protein has been resolved to 2.7 angstroms. This protein prevents hemolytic anemia from oxidative stress by stabilizing hemoglobin, thus making this gene a therapeutic target for patients with hemolytic anemia. This protein may have a proliferative effect and play a role in cancer development or progression. Related pseudogenes have been identified on chromosomes 5, 6, 10 and 13.
natural killer cell-enhancing factor B
, thiol-specific antioxidant 1
, thioredoxin peroxidase 1
, thioredoxin-dependent peroxide reductase 1
, Prx II-1
, Trx dependent peroxide reductase 1
, protector protein
, thiol specific antioxidant protein
, thiol-specific antioxidant protein
, thioredoxin dependent peroxide reductase 1
, thioredoxin reductase