anti-Peptidylprolyl Isomerase A (Cyclophilin A) (PPIA) Antikörper

PPIA encodes a member of the peptidyl-prolyl cis-trans isomerase (PPIase) family. Zusätzlich bieten wir Ihnen PPIA Proteine (57) und PPIA Kits (49) und viele weitere Produktgruppen zu diesem Protein an.

Alle Antikörper anzeigen Gen GeneID UniProt
PPIA 5478 P62937
PPIA 25518 P10111
PPIA 268373 P17742
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Top anti-PPIA Antikörper auf

Showing 10 out of 225 products:

Katalog Nr. Reaktivität Wirt Konjugat Applikation Bilder Menge Lieferzeit Preis Details
Rind (Kuh) Kaninchen Unkonjugiert WB WB Suggested Anti-PPIA Antibody Titration:  0.2-1 ug/ml  ELISA Titer:  1:312500  Positive Control:  Human brain 100 μL 2 bis 3 Tage
Human Kaninchen Unkonjugiert IHC (p), WB Western blot analysis of Cyclophilin A using anti- Cyclophilin A antibody .  Electrophoresis was performed on a 5-20% SDS-PAGE gel at 70V (Stacking gel) / 90V (Resolving gel) for 2-3 hours. The sample well of each  Lane was loaded with 50ug of sample under reducing conditions.   Lane 1: rat lung tissue lysates,   Lane 2: rat brain tissue lysates,   Lane 3: mouse lung tissue lysates,  Lane 4: HELA whole Cell lysates.  After Electrophoresis, proteins were transferred to a Nitrocellulose membrane at 150mA for 50-90 minutes. Blocked the membrane with 5% Non-fat Milk/ TBS for 1.5 hour at RT. The membrane was incubated with rabbit anti- Cyclophilin A antigen affinity purified polyclonal antibody (Catalog # ) at 0.5 µg/mL overnight at 4°C, then washed with TBS-0.1%Tween 3 times with 5 minutes each and probed with a goat anti-rabbit IgG-HRP secondary antibody at a dilution of 1:10000 for 1.5 hour at RT. The signal is developed using an Enhanced Chemiluminescent detection (ECL) kit (Catalog # EK1002) with Tanon 5200 system. A specific band was detected for Cyclophilin A at approximately 18KD. The expected band size for Cyclophilin A is at 18KD. IHC analysis of Cyclophilin A using anti-Cyclophilin A antibody . Cyclophilin A was detected in immunocytochemical section of THP-1 cell. Heat mediated antigen retrieval was performed in citrate buffer (pH6, epitope retrieval solution) for 20 mins. The tissue section was blocked with 10% goat serum. The tissue section was then incubated with 2µg/ml rabbit anti-Cyclophilin A Antibody  overnight at 4°C. DyLight®488 Conjugated Avidin was used as secondary antibody and incubated for 30 minutes at 37°C. The tissue section was developed using Strepavidin-Biotin-Complex (SABC)(Catalog # SA1094) with DAB as the chromogen. 100 μg 4 bis 6 Tage
Human Ziege Unkonjugiert ELISA, WB ABIN185542 (2µg/ml) staining of human lymph node lysate (35µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. 100 μg 6 bis 7 Tage
Rind (Kuh) Kaninchen Unkonjugiert WB 100 μL 2 bis 3 Tage
Human Kaninchen Unkonjugiert ICC, IF, IHC (p), WB WB Image Cyclophilin A antibody detects Cyclophilin A protein by western blot analysis. Raji whole cell extracts and cytoplasma+membrane and nuclear extracts (30 μg) were separated by 12% SDS-PAGE, and the membrane was blotted with Cyclophilin A antibody , at a dilution of 1:5000. IHC-P Image Immunohistochemical analysis of paraffin-embedded MDA-MB-468 xenograft, using Cyclophilin A, antibody at 1:500 dilution. 100 μL 3 bis 4 Tage
Rind (Kuh) Kaninchen Unkonjugiert IHC, WB WB Suggested Anti-PPIA Antibody Titration:  2.5ug/ml  Positive Control:  HepG2 cell lysate PPIA is strongly supported by BioGPS gene expression data to be expressed in Human HepG2 cells Human Intestine 100 μL 2 bis 3 Tage
Human Kaninchen Unkonjugiert ELISA, IHC (p), WB Immunohistochemistry (IHC) analysis of paraffin-embedded Rat Brain, antibody was diluted at 1:100. 100 μL Verfügbar
Rind (Kuh) Kaninchen Unkonjugiert IHC, IHC (p), WB 100 μL 11 bis 14 Tage
Huhn Kaninchen Unkonjugiert WB 100 μL 11 bis 14 Tage
Rind (Kuh) Ziege Unkonjugiert ELISA, WB 100 μg 11 bis 14 Tage

Am meisten referenzierte anti-PPIA Antikörper

  1. Human Monoclonal PPIA Primary Antibody für ELISA, WB - ABIN562340 : Rho, Roehrl, Wang: Tissue proteomics reveals differential and compartment-specific expression of the homologs transgelin and transgelin-2 in lung adenocarcinoma and its stroma. in Journal of proteome research 2009 (PubMed)
    Show all 3 Pubmed References

  2. Monoclonal PPIA Primary Antibody für ELISA, WB - ABIN533771 : Watashi, Ishii, Hijikata, Inoue, Murata, Miyanari, Shimotohno: Cyclophilin B is a functional regulator of hepatitis C virus RNA polymerase. in Molecular cell 2005 (PubMed)
    Show all 3 Pubmed References

  3. Human Polyclonal PPIA Primary Antibody für ELISA, WB - ABIN1993476 : Garcia-Moreno, Noerenberg, Ni, Järvelin, González-Almela, Lenz, Bach-Pages, Cox, Avolio, Davis, Hester, Sohier, Li, Heikel, Michlewski, Sanz, Carrasco, Ricci, Pelechano, Davis, Fischer, Mohammed et al.: System-wide Profiling of RNA-Binding Proteins Uncovers Key Regulators of Virus Infection. ... in Molecular cell 2019 (PubMed)

  4. Dog (Canine) Polyclonal PPIA Primary Antibody für ELISA, WB - ABIN547587 : Berthoux, Sebastian, Sokolskaja, Luban: Cyclophilin A is required for TRIM5{alpha}-mediated resistance to HIV-1 in Old World monkey cells. in Proceedings of the National Academy of Sciences of the United States of America 2005 (PubMed)

  5. Human Polyclonal PPIA Primary Antibody für IHC, IHC (p) - ABIN4301644 : Yamamoto, Kudo, Peng, Takata, Takakura, Teduka, Fujii, Mitamura, Taga, Uchida, Naito: Identification of aldolase A as a potential diagnostic biomarker for colorectal cancer based on proteomic analysis using formalin-fixed paraffin-embedded tissue. in Tumour biology 2016 (PubMed)

  6. Mouse (Murine) Polyclonal PPIA Primary Antibody für IHC, WB - ABIN3021253 : Xiao, Song, Deng, Lv, Ma, Gao, Zhou, Zhang, Xu: Inhibition of cyclophilin A suppresses H2O2-enhanced replication of HCMV through the p38 MAPK signaling pathway. in FEBS open bio 2016 (PubMed)

  7. Human Polyclonal PPIA Primary Antibody für IF (p), IHC (p) - ABIN759716 : Kang, Kim, Hong, Park, Heinsen, Lee, Ravid, Ferrer, Yoo, Kwon, Park: Large-scale analysis of posttranslational modifications in the hippocampus of patients with Alzheimer's disease using pI shift and label-free quantification without enrichment. in Analytical and bioanalytical chemistry 2014 (PubMed)

Weitere Antikörper gegen PPIA Interaktionspartner

Xenopus laevis Peptidylprolyl Isomerase A (Cyclophilin A) (PPIA) Interaktionspartner

  1. Over-expression leads to an expansion and disorganisation of the neural crest domain.

Human Peptidylprolyl Isomerase A (Cyclophilin A) (PPIA) Interaktionspartner

  1. miR-192-5p sensitizes breast cancer cells to doxorubicin by targeting PPIA.

  2. cyclophilin A (CypA) was identified as an important molecule for USP4-mediated oncogenic activity in hepatocellular carcinoma.

  3. Plasma CyP A and CD147 can serve as indicators of renal disease progression in type 2 diabetes patients

  4. The CypA genetic polymorphisms of rs3735481 and rs9638978 may be associated with severe PE, and rs9638978 AA genotype may be associated with an increasing risk of early onset severe PE in Han Chinese women. High CypA levels in serum and placenta may contribute to the pathogenesis of severe PE.

  5. The model is consistent with experimental data also from previous works and supports the concept that the peptide does not interfere with other CypA activities unrelated to AIF activation; therefore, it may serve as an ideal template for generating future non-peptidic antagonists.

  6. our findings reveal a novel ubiquitination-based mechanism by which CypA regulates the replication of influenza A virus.

  7. Molecular structure of cyclophilin A in complex with alispovir has been presented.

  8. Cyclophilin A is required for HIV-1 Tat palmitoylation .

  9. These results suggested that the CyPA located on SV-HUC-1 cell membranes may be the potential receptor of Mycoplasma genitalium adhesion protein (MgPa), which could provide an experimental basis for elucidating the function of MgPa and the possible pathogenic mechanism of M. genitalium.

  10. increased serum cyclophilin A concentrations could reflect trauma severity and unfavorable outcome after head trauma, substantializing cyclophilin A as a potential biomarker for prognostic prediction of TBI

  11. Here, the binding site of AIF(Delta1-121) and AIF(370-394) on CypA has been mapped by NMR spectroscopy and biochemical studies, and a molecular model of the complex has been proposed. The authors show that AIF(370-394) interacts with CypA on the same surface recognized by AIF(Delta1-121) protein and that the region is very close to the CypA catalytic pocket.

  12. CyPA was significantly increased in convalescent COPD patients and further elevated in COPD patients with acute exacerbation.

  13. CypA expression was not an independent prognostic factor, but correlated with poor prognosis of lung adenocarcinoma

  14. Extracellular cyclophilin A augments platelet-dependent thrombosis and thromboinflammation.

  15. the increased expression of CyPA in ectopic endometrial tissue is associated with endometrioma recurrences and vascularity.

  16. Taken together, these findings reveal an essential role of CypA in boosting RIG-I-mediated antiviral immune responses by controlling the ubiquitination of RIG-I and MAVS.

  17. Data show that cyclophilin A (CypA) is up-regulated in oral squamous cell carcinoma (OSCC) arising from oral submucous fibrosis (OSF).

  18. K308 of NS5A is indispensable for both RNA and NS5B binding, whereas W316 is essential for protein-protein interactions with CypA and NS5B.

  19. PPIA is differentially expressed in lesional biopsy specimens from patients with atopic eczema relative to normal skin

  20. inosine-5'-monophosphate dehydrogenase 2 (IMPDH2) is an intracellular target of the PPIA-Sanglifehrin A binary complex.

Mouse (Murine) Peptidylprolyl Isomerase A (Cyclophilin A) (PPIA) Interaktionspartner

  1. The present study reveals the positive correlation of CypA/CD147 signaling and osteoclast-related MMP-9 expression in mice inflammatory periapical lesions progression. Therefore, intervention of CypA/CD147 signaling could probably provide a potential therapeutic target for attenuating inflammatory bone resorption.

  2. Extracellular cyclophilin A augments platelet-dependent thrombosis and thromboinflammation.

  3. Endothelial cell-derived CypA (especially AcK-CypA) causes pulmonary artery hypertension by a presumptive mechanism involving increased EC apoptosis, inflammation, and oxidative stress.

  4. ox-LDL-induced CyPA secretion requires vesicle transportation, actin remodeling and ROCK-dependent diphosphorylation of myosin light chains in vascular smooth muscle cells.

  5. knockdown of CD147 on Hepa1-6 cells resulted in significantly increased T cells chemotaxis induced by CypA both in vivo and in vitro.

  6. CypA dually exerts pro-osteogenic and anti-osteoclastic effects.

  7. Extracellular CyPA activates platelets via cluster of differentiation 147-mediated phosphoinositid-3-kinase/Akt-signaling, leading to enhanced adhesion and thrombus formation independently of intracellular CyPA.

  8. CypA provided stability for NF-kappaB p65 and promoted NF-kappaB p65 nuclear translocation, resulting in increased nuclear accumulation and enhanced NF-kappaB activity.

  9. Newborn CypA-deficient pups exhibited generalized, pronounced skeletal defects, while high-resolution micro-computed tomography analyses of the femurs and lumbar vertebrae revealed delayed or incomplete endochondral ossification.

  10. Cyclophilin A secretion was increased in lymphocytes from atherogenic mice.

  11. CD137-CD137L interactions mediated via regulation of CyPA contribute to the progression of atherosclerosis.

  12. Reactive oxygen species-dependent CypA secretion by endothelial cells is an important signaling mechanism through which endothelial cell reactive oxygen species regulate susceptibility of structural components of the aortic wall to aortic dissection.

  13. CyPA is an important regulator for AngII-induced ROS generation in VSMC through interaction with p47phox and cell cytoskeleton, which enhances the translocation of p47phox to caveolae.

  14. CYPA was identified as a novel host restriction factor that confered protection against rotavirus infection.

  15. CyPA expression increases and may modulate inflammatory cell adhesion and interleukin-6 expression inducing vascular smooth muscle cell migration and inflammatory cell extravasation in a time-dependent manner

  16. How does oxidative stress contribute to vascular disease? Data from vascular smooth muscle suggest that reduced glutathione peroxidase 1 (i.e., oxidative stress) promotes secretion of CypA which mediates paracrine inflammation of vasculature.

  17. CsA inhibits BKV replication through CypA and NFAT, which may be potential targets of anti-BKV treatment

  18. CyPA is an important Ca(2+) regulator in platelets, a critical mechanism for arterial thrombosis.

  19. CypA is a key target for treating APOE4-mediated neurovascular injury and the resulting neuronal dysfunction and degeneration

  20. truncated CyPA detected in brain following prion infection may have an important role in the activation of brain-derived primary astroglia and microglia in prion disease and perhaps other neurodegenerative or neuroinflammatory diseases.

PPIA Antigen-Profil

Protein Überblick

This gene encodes a member of the peptidyl-prolyl cis-trans isomerase (PPIase) family. PPIases catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and accelerate the folding of proteins. The encoded protein is a cyclosporin binding-protein and may play a role in cyclosporin A-mediated immunosuppression. The protein can also interact with several HIV proteins, including p55 gag, Vpr, and capsid protein, and has been shown to be necessary for the formation of infectious HIV virions. Multiple pseudogenes that map to different chromosomes have been reported.

Genbezeichner und Symbole assoziert mit PPIA

  • peptidylprolyl isomerase A (PPIA) Antikörper
  • peptidylprolyl isomerase Aa (cyclophilin A) (ppiaa) Antikörper
  • peptidylprolyl isomerase A (cyclophilin A) L homeolog (ppia.L) Antikörper
  • cyclophilin A (Cypa) Antikörper
  • cyclophilin A (CNB01230) Antikörper
  • cyclophilin A (CNB01290) Antikörper
  • cyclophilin A (Tc00.1047053506925.300) Antikörper
  • cyclophilin A (Tb11.03.0250) Antikörper
  • cyclophilin a (CYPA) Antikörper
  • peptidylprolyl isomerase A (cyclophilin A) (Ppia) Antikörper
  • peptidylprolyl isomerase A (cyclophilin A) (ppia) Antikörper
  • peptidylprolyl isomerase A (Ppia) Antikörper
  • peptidylprolyl isomerase A (cyclophilin A) (PPIA) Antikörper
  • 2700098C05 Antikörper
  • Cphn Antikörper
  • CYCA Antikörper
  • CyP-18 Antikörper
  • CyP-A Antikörper
  • Cyp1 Antikörper
  • cypA Antikörper
  • CYPH Antikörper
  • fa93g09 Antikörper
  • MGC75715 Antikörper
  • MT-ND1 Antikörper
  • MTND1 Antikörper
  • NADH1 Antikörper
  • ND1 Antikörper
  • ppia Antikörper
  • PPIA-2 Antikörper
  • PPIase A Antikörper
  • wu:fa93g09 Antikörper
  • wu:fb05e11 Antikörper
  • wu:fb13h02 Antikörper
  • wu:fb15a05 Antikörper

Bezeichner auf Proteinebene für PPIA

PPIase A , cyclophilin A , cyclophilin T , cyclophilin T-cell , cyclosporin A-binding protein , peptidyl-prolyl cis-trans isomerase A , rotamase A , 2-peptidylprolyl isomerase A , peptidylprolyl isomerase A (cyclophilin A) , cyclophilin 18 , immunophilin , cyclophilin-like , T cell cyclophilin , cyclophilin , cyclophilin a , p1B15 , p31 , Cyclophilin A , Cyclosporin A-binding protein , Rotamase A , SP18 , NADH dehydrogenase subunit 1 , NADH-ubiquinone oxidoreductase chain 1 , Peptidyl-prolyl cis-trans isomerase A

281418 Bos taurus
336612 Danio rerio
100008724 Oryctolagus cuniculus
397637 Sus scrofa
463386 Pan troglodytes
398630 Xenopus laevis
692737 Bombyx mori
574102 Macaca mulatta
5478 Homo sapiens
3255869 Cryptococcus neoformans var. neoformans JEC21
3255972 Cryptococcus neoformans var. neoformans JEC21
3554513 Trypanosoma cruzi strain CL Brener
3664945 Trypanosoma brucei brucei strain 927/4 GUTat10.1
5652501 Leishmania major strain Friedlin
25518 Rattus norvegicus
394470 Xenopus (Silurana) tropicalis
100594480 Nomascus leucogenys
268373 Mus musculus
776282 Gallus gallus
608151 Canis lupus familiaris
100173012 Pongo abelii
493966 Felis catus
443258 Ovis aries
100973085 Pan paniscus
100722609 Cavia porcellus
100769490 Cricetulus griseus
101925040 Macaca fascicularis
Ausgewählte Anbieter für anti-PPIA (PPIA) Antikörper
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