Patatin-Like phospholipase Domain Containing 3 Proteine (PNPLA3)

The protein encoded by PNPLA3 is a triacylglycerol lipase that mediates triacylglycerol hydrolysis in adipocytes. Zusätzlich bieten wir Ihnen PNPLA3 Antikörper (99) und PNPLA3 Kits (17) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
PNPLA3 80339 Q9NST1
PNPLA3 116939 Q91WW7
PNPLA3 362972  
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Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Insektenzellen Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 50 Days
Insektenzellen Maus rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Anmelden zum Anzeigen 50 bis 55 Tage
Wheat germ Human GST tag 10 μg Anmelden zum Anzeigen 11 bis 12 Tage
HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Anmelden zum Anzeigen Verfügbar
Escherichia coli (E. coli) Human Unkonjugiert   100 μg Anmelden zum Anzeigen 11 bis 18 Tage
Escherichia coli (E. coli) Ratte Unkonjugiert   100 μg Anmelden zum Anzeigen 11 bis 18 Tage
Escherichia coli (E. coli) Human Unkonjugiert   5 applications Anmelden zum Anzeigen 1 bis 2 Tage

PNPLA3 Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Human , , ,
, , ,
Mouse (Murine) ,
Rat (Rattus)

Am meisten referenzierte PNPLA3 Proteine

  1. Human PNPLA3 Protein expressed in Wheat germ - ABIN1315587 : Winberg, Motlagh, Stenkula, Holm, Jones: Adiponutrin: a multimeric plasma protein. in Biochemical and biophysical research communications 2014 (PubMed)

Weitere Proteine zu Patatin-Like phospholipase Domain Containing 3 (PNPLA3) Interaktionspartnern

Human Patatin-Like phospholipase Domain Containing 3 (PNPLA3) Interaktionspartner

  1. Findings suggest a significant association between variants in COL13A1, ADIPOQ, SAMM50, and PNPLA3, and risk of NAFLD/elevated transaminase levels in Mexican adults with an admixed ancestry.

  2. PNPLA3 determines the risk of NASH (zeige SAMSN1 Proteine) and significant fibrosis.

  3. Our study suggested that PNPLA3 loci (rs2294918, rs2294919) were associated with HBV-related HCC in Han Chinese.

  4. In this Sri (zeige SRI Proteine) Lankan community cohort study, the annual incidence of non-alcoholic fatty liver disease (NAFLD) was 6.2%. Incident NAFLD was associated with general and central obesity, raised triglycerides and diabetes, and showed a tendency of association with PNPLA3 gene polymorphisms.

  5. Deleterious and protective mutations in MTTP, PNPLA3, and TM6SF2 have been found in Japanese males at risk for non-alcoholic fatty liver disease.

  6. Although no single variant reached genome-wide significance, an association signal was observed for PNPLA3 rs738409, a common single nucleotide polymorphism that has been associated with a variety of liver-related pathologies including alcoholic cirrhosis. This preliminary analysis suggests a role for PNPLA3 variation and several gene sets/pathways that may influence risk for alcoholic hepatitis among heavy drinkers.

  7. These findings suggest that PNPLA3 rs1010023 may predispose chronic hepatitis B patients to hepatic steatosis but protects them from glucose dysregulation by attenuating insulin (zeige INS Proteine) resistance.

  8. Its genotype showes an association with NAFLD, NASH (zeige SAMSN1 Proteine), fibrosis, and cirrhosis.

  9. Individuals misusing alcohol who carry a particular variant of the gene PNPLA3 are more at risk of developing severe alcoholic hepatitis.

  10. PNPLA3 is the first locus to be reproducibly and strongly associated with steatosis, fibrosis/cirrhosis in various liver diseases with different etiologies and even HCC (zeige FAM126A Proteine) in fatty liver diseases.

Mouse (Murine) Patatin-Like phospholipase Domain Containing 3 (PNPLA3) Interaktionspartner

  1. Histone acetylation plays a role in the modulation of PNPLA3 levels in the liver exposed to binge ethanol drinking.

  2. Neither ablation nor overexpression of wild-type PNPLA3 affects liver fat content in mice, whereas hepatic overexpression of the human 148M transgene causes steatosis.

  3. PNPLA3 plays a role in remodeling TAG in lipid droplets, as they accumulate in response to food intake

  4. adiponutrin/PNPLA3 is regulated by two key factors of the glycolytic and lipogenic pathways, raising the question of its implication in the metabolism of carbohydrates and lipids

  5. data argue against a role for Pnpla3 loss-of-function in fatty liver disease or metabolic syndrome in mice.

  6. Loss of Pnpla3 does not cause fatty liver, liver enzyme elevation, or insulin (zeige INS Proteine) resistance in mice.

  7. Microarray-based gene profiling showed that the expression level of PNPLA3 in hepatocytes is correlated with that of genes associated with the lipogenic pathway such as ME1 (zeige ME1 Proteine), SPOT14 (zeige THRSP Proteine), and SCD1 (zeige SCD Proteine).

  8. data suggest that murine ATGL (zeige PNPLA2 Proteine) but not adiponutrin contributes to net adipocyte lipolysis and that ATGL (zeige PNPLA2 Proteine) and adiponutrin are oppositely regulated by insulin (zeige INS Proteine) both in vitro and in vivo

PNPLA3 Protein Überblick

Protein Überblick

The protein encoded by this gene is a triacylglycerol lipase that mediates triacylglycerol hydrolysis in adipocytes. The encoded protein, which appears to be membrane bound, may be involved in the balance of energy usage/storage in adipocytes.

Genbezeichner und Symbole assoziert mit PNPLA3

  • patatin like phospholipase domain containing 3 (PNPLA3)
  • patatin-like phospholipase domain containing 3 (Pnpla3)
  • Adpn Protein
  • C22orf20 Protein
  • iPLA(2)epsilon Protein

Bezeichner auf Proteinebene für PNPLA3

acylglycerol O-acyltransferase , adiponutrin , calcium-independent phospholipase A2-epsilon , iPLA2-epsilon , iPLA2epsilon , patatin-like phospholipase domain-containing protein 3

80339 Homo sapiens
116939 Mus musculus
362972 Rattus norvegicus
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