Paraoxonase 1 (PON1) ELISA Kits

Human Paraoxonase 1 (PON1) Interaktionspartner

1. PON1 L55M genetic polymorphisms may be associated with the risk of breast cancer and could potentially serve as useful genetic markers for tumor prognosis in some populations of Chinese women.

2. Paraoxonase-1 (PON1) induces metastatic potential and apoptosis escape via its antioxidative function in lung cancer cells

3. This study is the first study to investigate serum PON1 enzyme activity in patients with cutaneous anthrax. We concluded that oxidative stress was increased whereas serum PON1 activity was decreased in patients with cutaneous anthrax. These results indicate that lower PON1 activity is associated with an oxidant-antioxidant imbalance.

4. The L55M polymorphism associated with systemic lupus erythematosus and anti-phospholipid syndrome in a population from Cairo, Egypt, while the Q192R polymorphism played no role in disease susceptibility.

5. PON1 (Q192R and L55M) polymorphisms may play a crucial role in pathogenesis and susceptibility of insulin (zeige INS ELISA Kits) resistance thus leads to the development of type 2 diabetes in South Indian population.

6. PON1 protein can be detected in plasma and resides in the high-density lipoprotein fraction and protects against Oxidative stress by hydrolyzing certain oxidized lipids in lipoproteins, macrophages and Atherosclerotic lesions.

7. Our study provides preliminary support for the involvement of organophosphate pesticides and PON1 in Parkinson's disease-related motor, cognitive, or depressive symptom progression.

8. The distribution of genotype frequencies in the assessed women (PON1 Q192R polymorphism) was QQ = 20%, QR = 48% and RR = 32%. Significantly higher serum FABP4 (zeige FABP4 ELISA Kits) levels were found in women with genotype QR/RR (20.6 +/- 2.20 ng/mL), when compared with the levels found in the QQ group (12.8 +/- 1.70 ng/mL) (p = .004).

9. rare genetic variation in PON1 was associated with ischemic stroke, with stronger associations identified in those of AA. Increased focus on PON1 enzyme function and its role in cerebrovascular disease is warranted.

10. PON1 arylesterase activity correlated negatively with sCD40L, ADMA, and sICAM-1 levels in overweight patients with newly diagnosed untreated hyperlipidaemia.

Mouse (Murine) Paraoxonase 1 (PON1) Interaktionspartner

1. PON1 overexpression protects against AAA (zeige AAAS ELISA Kits) progression by reducing oxidative stress, apoptosis and inflammation

2. Paraoxonase 1 (PON1) influence circadian gene expression and period length

3. results suggest that Hyperhomocysteinemia plays an intricate role in dysfunctional HDL (zeige HSD11B1 ELISA Kits), owing to the lack of PON1. This contributes to vascular endothelial impairment and atherosclerosis.

4. Maternal PON1 status modulates the effects of repeated gestational chlorpyrifos oxon exposure on fetal-brain gene expression and on inhibition of both maternal and fetal biomarker enzymes.

5. 5,6-dihydroxyeicosatrienoate-1,5-lactone, a stable metabolite of arachidonic acid, is a potential substrate for PON1.

6. HDL (zeige HSD11B1 ELISA Kits) (mostly HDL3), stimulates PON1 antiatherogenic activities in mouse macrophages.

7. Findings suggest that Pon1 interacts with diverse cellular processes from energy metabolism and anti-oxidative defenses to cell cycle, cytoskeleton dynamics, and synaptic plasticity essential for normal brain homeostasis

8. The study demonstrated a significant decline in PON1 activity which correlates with increased LDL oxidation after 8 months of age in Wistar rats.

9. PON1 plays a protective role against hepatic derangements, secondary to fat and cholesterol overnutrition. PON1 deficiency is associated with oxidative stress and metabolic alterations leading to liver steatosis.

10. PON1 is not essential for normal development, function, ageing, and the defense against light damage of the mouse retina.

Pig (Porcine) Paraoxonase 1 (PON1) Interaktionspartner

1. PON1 behaves as a negative acute phase protein (zeige ORM1 ELISA Kits) in pigs since a significant decrease (P<0.05) in its activity after 72 h of the induction of the inflammation was observed with all substrates.

Cow (Bovine) Paraoxonase 1 (PON1) Interaktionspartner

1. characterization the SNPs in the promoter region of the bovine PON1 gene, and to evaluation of association with serum PON1 activity in periparturient Holstein cows

2. The results suggest that PON1 might be a better parameter for minimal redox state changes in serum, shortly after labour in the examined breeds.

3. Data indicate that Cu(2+), Mn(2+), Zn(2+), Ni(2 (zeige VMP1 ELISA Kits)+), and Pb(2+) were found to inhibite the paraoxonase 1 (PON1) enzyme activity in a concentration-dependent fashion.

4. The aim of this study was to evaluate expression of the natural anti-oxidants paraoxonase (PON) 1, 2 and 3 in granulosa cells and PON1 activity in follicular fluid and plasma of dairy cows.

5. Significantly lower PON1 activity and PON1/high density lipoprotein ratio in lactating cows compared to heifers showed that metabolic efforts during pregnancy, parturition and lactation influence PON1 activity due to oxidative stress.

6. The activity of PON1 and malondialdehyde in late pregnancy and early lactation in dairy cattle is reported.

Rabbit Paraoxonase 1 (PON1) Interaktionspartner

1. ApoE (zeige APOE ELISA Kits) mimetic peptide reduces plasma lipid hydroperoxide content with a concomitant increase in HDL (zeige HSD11B1 ELISA Kits) paraoxonase activity

2. PON1 can decrease the AChE inhibition, and alleviated clinical signs and tissue damage caused by dichlorvos.