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PITX1 encodes a member of the RIEG/PITX homeobox family, which is in the bicoid class of homeodomain proteins. Zusätzlich bieten wir Ihnen PITX1 Antikörper (55) und PITX1 Kits (9) und viele weitere Produktgruppen zu diesem Protein an.
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As a transcriptional activator, PITX1 regulates apoptosis-related genes, including PDCD5 (zeige PDCD5 Proteine), during gastric carcinogenesis.
we demonstrated a novel oncogenic mechanism of PTP1B (zeige PTPN1 Proteine) on affecting PITX1/p120RasGAP (zeige RASA1 Proteine) in colorectal carcinoma(CRC (zeige CALR Proteine)). Regorafenib inhibited CRC (zeige CALR Proteine) survival through reserving PTP1B (zeige PTPN1 Proteine)-dependant PITX1/p120RasGAP (zeige RASA1 Proteine) downregulation. PTP1B (zeige PTPN1 Proteine) may be a potential biomarker predicting regorafenib effectiveness, and a potential solution for CRC (zeige CALR Proteine)
Methylation status of PITX1 and even more so of lincRNA C5orf66-AS1 is a promising prognostic biomarker in HNSCC, in particular for HPV-negative patients. Further prospective evaluation is warranted
role for E2F1 (zeige E2F1 Proteine) and TFDP1 (zeige TFDP1 Proteine) in the transcriptional regulation of PITX1 in articular chondrocytes
PITX1 expression may be involved in tumor progression and is a potential tumor suppressor gene and prognostic marker for cutaneous malignant melanoma.
PTP1B (zeige PTPN1 Proteine) dephosphorylates PITX1 to weaken its protein stability and the transcriptional activity for p120RasGAP (zeige RASA1 Proteine) gene expression
To date, at least ten loci and four non-syndromic polydactyly-causing genes, including the GLI3 (zeige GLI3 Proteine) gene, the ZNF141 gene, the MIPOL1 (zeige MIPOL1 Proteine) gene and the PITX1 gene, have been identified. (Review)
Low PITX1 expression is associated with lung metastasis in osteosarcoma.
We discuss the genetic abnormality that causes Liebenberg syndrome, the genomic rearrangement at the PITX1 locus on chromosome 5.
Down-regulation of PITX1 expression might contribute to the progression of cutaneous malignant melanoma via promoting cell proliferative activity
Pitx1 distal enhancer loss have only mild effects on Pitx1 expression in the hindlimb and no overt effects on hindlimb or mandibular morphology.
data suggest that PITX1 promotes chondrogenesis and myogenesis in the hindlimb by direct regulation of several key members of the cartilage and muscle transcriptional networks.
Results indicate autonomously programmed differences in forelimb and hindlimb cartilage precursors of the limb skeleton are controlled, at least in part, by Pitx1 and suggest this has an important role in generating distinct limb-type morphologies.
Pitx1 targets sites that are in a similar chromatin state in Forelimbs (FLs) and hindlimbs and controls expression of patterning genes as well as the chondrogenic program.
Pitx1 influences hindlimb morphology both through the activation of hindlimb-specific enhancers as well as through the hindlimb-specific modulation of enhancers that are active in both sets of limbs
The results suggest that PITX2 (zeige PITX2 Proteine) and PITX1 have overlapping roles in thyrotroph function and response to hypothyroidism.
PITX1 haploinsufficiency may cause a developmental field defect preferentially affecting the lateral lower leg.
It was shown that, firstly, Pitx1 influences hindlimb outgrowth by regulating Tbx4 (zeige TBX4 Proteine) expression levels and that, subsequently,Pitx1 shapes hindlimb bone and soft tissue morphology independently of Tbx4 (zeige TBX4 Proteine).
These findings provide evidence that c-Abl (zeige ABL1 Proteine) participates in modulating Pitx1 expression in the apoptotic response to DNA damage.
Thus, Pitx1 and Pitx2 (zeige PITX2 Proteine) genes are required for sustained hindlimb bud growth and formation of hindlimbs
Pitx1 and the related protein Pitx2c (zeige PITX2 Proteine) are required for endogenous cement gland development. Pitx1 transcriptionally activates cement gland differentiation genes, both directly and indirectly
Pitx1 is expressed in hindlimbs and expression is similar in both developing and regenerating limb buds.
This gene encodes a member of the RIEG/PITX homeobox family, which is in the bicoid class of homeodomain proteins. Members of this family are involved in organ development and left-right asymmetry. This protein acts as a transcriptional regulator involved in basal and hormone-regulated activity of prolactin.
paired-like homeodomain 1
, paired-like homeodomain transcription factor 1
, pituitary homeobox 1
, hindlimb expressed homeobox protein backfoot
, hindlimb-expressed homeobox protein backfoot
, homeobox protein PITX1
, pituitary homeo box 1
, pituitary otx-related factor
, homeobox protein P-OTX
, pituitary OTX-related factor