Paired Box 4 Proteine (PAX4)

PAX4 is a member of the paired box (PAX) family of transcription factors. Zusätzlich bieten wir Ihnen PAX4 Antikörper (71) und PAX4 Kits (4) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
PAX4 5078 O43316
PAX4 18506 P32115
PAX4 83630 O88436
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Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Insektenzellen Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 50 Days
Insektenzellen Maus His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 50 Days
Wheat germ Human GST tag 10 μg Anmelden zum Anzeigen 11 bis 12 Tage
Escherichia coli (E. coli) Human His tag Validation with Western Blot 50 μg Anmelden zum Anzeigen 11 Days
Hefe Ratte His tag   1 mg Anmelden zum Anzeigen 60 bis 71 Tage
Escherichia coli (E. coli) Human Unkonjugiert   5 applications Anmelden zum Anzeigen 1 bis 2 Tage

PAX4 Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Human , ,
Mouse (Murine) ,

Rat (Rattus)

Weitere Proteine zu Paired Box 4 (PAX4) Interaktionspartnern

Human Paired Box 4 (PAX4) Interaktionspartner

  1. genetic association studies in population in Republic of Korea: Data suggest that SNPs in PAX4 and GLP1R are associated with type 2 diabetes (T2D) in the population studied. In genome-wide associations, PAX4 Arg192His increased risk of T2D; GLP1R Arg131Gln decreased risk of T2D. (PAX4 = paired box 4 protein; GLP1R = glucagon-like peptide 1 receptor)

  2. The rs10229583 polymorphism near PAX4 is associated with gestational diabetes mellitus in Chinese women.

  3. Study identified the association of a PAX4 Asian-specific missense variant rs2233580 with type 2 diabetes in an exome-chip association analysis, supporting the involvement of PAX4 in the pathogenesis of type 2 diabetes.

  4. Viability of beta-cell was reduced under glucotoxic stress condition for the cells overexpressing either PAX4 R192H or PAX4 P321H or both. Thus these PAX4 polymorphisms may increase T2D risk by defective transcription regulation of target genes and/or decreased beta-cell survival in high glucose condition.

  5. PAX4 IVS7-1G>A contributes to the pathogenesis of diabetes in this maturity-onset diabetes of the young, type 9 family through beta-cell dysfunction

  6. The PAX4 variant rs6467136 was associated with the therapeutic effect of rosiglitazone in Chinese T2DM patients.

  7. PAX4-miR-144/451-ADAMs axis regulates human epithelial cancer metastasis

  8. These data suggest that acute PAX4 overexpression can reduce expression of aristaless related homeobox and glucagon during embryonic stem cell differentiation resulting in improved numbers of unihormonal insulin-positive cells.

  9. Tph1 and increased EC cell number occurred before the onset of obesity and hyperleptinemi. In addition, leptin deficiency was associated with reduced Pax4 mRNA, oral leptin treatment enhanced both Tph1 and Pax4 mRNA.

  10. MAFA nuclear expression in pancreatic alpha and beta cells, and the percentage of alpha cells expressing PAX4 are altered in patients with type 2 diabetes.

  11. PAX4 R192H polymorphism generated a protein with defect in transcriptional repressor activities on its target genes, which may lead to beta-cell dysfunction associated with maturity onset diabetes of the young and early onset-age of type 2 diabetes.

  12. A1168C polymorphism in PAX4 gene may not play an essential role in the genetic susceptibility of the islet autoantibody-negative ketosis-prone diabetes in Chinese Han population.

  13. A novel mutation of PAX4 is likely to be associated with diabetes in this Japanese family.

  14. study did not detect causal mutations in the PAX4 gene in a large group of Czech MODYX probands, which may suggest-together with data from other European populations- MODY in Caucasians could only very rarely, if ever, be attributed to PAX4 mutations

  15. PAX4 R192H mutation (rs2233580) was significantly associated with impaired glucose tolerance in childhood acute lymphoblastic leukemia.

  16. The A1168C single nucleotide polymorphism in PAX4 gene may not play an essential role in genetic T1DM susceptibility in Chinese Han population

  17. Sixteen single-nucleotide polymorphisms(SNPs) were evaluated for IRS1 and 10 for PAX4. Transmission disequilibrium testing neither show type I diabetes association of SNPs in the two genes, nor did haplotype analysis.

  18. Four genes, PCSK1, (P=0.008), EGFR,(P=0.003), PAX4,(P=0.008), and LYN,(P=0.002) consistently yielded statistical evidence for association with longevity.

  19. Beta-cell dysfunction in late-onset diabetic subjects carrying homozygous mutation in transcription factor Pax4.

  20. The R121W mutation in PAX4 is a predisposing factor for the development of type 2 diabetes in Okinawans.

Mouse (Murine) Paired Box 4 (PAX4) Interaktionspartner

  1. Down-regulation of PAX4 or its target gene encoding the p97/VCP ATPase reduced myofibril disassembly.

  2. Ectopic expression of Pax4 in pancreatic delta cells results in beta-like cell neogenesis.

  3. The coordinated regulation of distinct cellular pathways particularly related to ER homeostasis by PAX4 not achieved by the mutant variant PAX4R129W alleviates beta cell degeneration and protects against diabetes mellitus.

  4. This work establishes the existence of a bona fide PAX4-enriched cell subpopulation nested within pancreatic islets that can expand in periods of increased functional demands, and exhibit improved viability in response to pathophysiological situations.

  5. Pax4 expression is not sufficient to transduce pancreatic alpha cells into beta cells. Overexpression of Pax4 in alpha cells may not increase functional beta cell number in diabetic patients

  6. Adult glucagon producing cells can be converted into beta-like cells upon Pax4 misexpression.

  7. RBM4 promoted insulin gene expression by altering the isoform balance of the transcription factors Isl1 and Pax4 via alternative splicing control.

  8. these finding demonstrate that, downstream of Neurog3, the specification of a subset of enteroendocrine subtypes relies on both Arx and Pax4, while others depend only on Arx or Pax4.

  9. Pax4 protects adult islets from stress-induced apoptosis by suppressing selective nuclear factor-kappaB target genes while increasing Bcl-2 levels.

  10. Pax4 has a role in facilitating embryonic stem cell differentiation into the pancreatic lineage

  11. A2 and E1 elements in endocrine promoters are essential for Pax4 expression

  12. activity appears essential for appropriate initiation of beta-cell differentiation

  13. Pax4 is an essential regulator of pancreatic beta-cell development [review]

  14. Pax-4 and Arx act as transcriptional repressors that control the expression level of one another, thereby mediating proper endocrine fate allocation in the pancreas.

  15. The higher insulin production with glucose dependent modulation suggests that pax4 expression can drive more mature insulin producing cells.

  16. Data further support the notion that Pax4 activity is necessary to establish appropriate patterns of gene expression in endocrine progenitors of the digestive tract.

  17. PAX4 gene is not associated with the risk of type 1 diabetes in a Han Chinese sample.

  18. The daily changes in Pax4 expression may contribute to daily changes in function in the differentiated retinal photoreceptor.

  19. Ectopically expressed Pax4 using different cell-specific promoters demonstrate that Pax4 forces endocrine precursor cells, as well as mature alpha cells, to adopt a beta cell destiny.

PAX4 Protein Überblick

Protein Überblick

This gene is a member of the paired box (PAX) family of transcription factors. Members of this gene family typically contain a paired box domain, an octapeptide, and a paired-type homeodomain. These genes play critical roles during fetal development and cancer growth. The paired box 4 gene is involved in pancreatic islet development and mouse studies have demonstrated a role for this gene in differentiation of insulin-producing beta cells.

Genbezeichner und Symbole assoziert mit Paired Box 4 Proteine (PAX4)

  • paired box 4 (PAX4)
  • paired box 4 (Pax4)
  • KPD Protein
  • MODY9 Protein
  • Pax-4 Protein
  • PAX4 Protein

Bezeichner auf Proteinebene für Paired Box 4 Proteine (PAX4)

paired box gene 4 , paired box protein Pax-4 , paired domain gene 4 , paired box 4 , paired-box gene 4 , paired box protein Pax-4-like

5078 Homo sapiens
18506 Mus musculus
83630 Rattus norvegicus
472503 Pan troglodytes
482268 Canis lupus familiaris
554328 Ovis aries
698351 Macaca mulatta
100137394 Papio anubis
100354681 Oryctolagus cuniculus
100402138 Callithrix jacchus
100588587 Nomascus leucogenys
526172 Bos taurus
100715909 Cavia porcellus
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