PRKC, Apoptosis, WT1, Regulator Proteine (PAWR)

The tumor suppressor WT1 represses and activates transcription. Zusätzlich bieten wir Ihnen PAWR Antikörper (67) und PAWR Kits (7) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
PAWR 5074 Q96IZ0
Ratte PAWR PAWR 64513 Q62627
PAWR 114774 Q925B0
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Top PAWR Proteine auf

Showing 4 out of 4 products:

Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Escherichia coli (E. coli) Maus His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 30 bis 35 Tage
Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 30 bis 35 Tage
HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Anmelden zum Anzeigen 10 bis 12 Tage
Wheat germ Human GST tag 10 μg Anmelden zum Anzeigen 11 bis 12 Tage

PAWR Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Human , ,
, ,
Mouse (Murine)

Weitere Proteine zu PRKC, Apoptosis, WT1, Regulator (PAWR) Interaktionspartnern

Human PRKC, Apoptosis, WT1, Regulator (PAWR) Interaktionspartner

  1. PAR4 is the target of mir (zeige MLXIP Proteine)-107 in colorectal cancer cells.

  2. we confirmed that the RASSF2-PAR-4 axis was mainly responsible for miR-7 functions in CAFs using bioinformatics methods. Overexpression of miR-7 in CAFs led to down-regulation of RASSF2, which dramatically decreased the secretion of PAR-4 from CAFs and then enhanced the proliferation and migration of the co-cultured cancer cells.

  3. we investigated in the present study the mechanisms regulating the accumulation of a 25kDa (zeige SFRS9 Proteine) cleaved-Par-4 (cl-Par-4) fragment in ovarian and endometrial cancer cell lines

  4. Authors demonstrate that TRIM21 (zeige TRIM21 Proteine) expression predicts survival in pancreatic cancer patients. This work highlights a novel mechanism of Par-4 regulation, and identifies a novel prognostic marker and potential therapeutic target for pancreatic cancer.

  5. Data suggest that PAR4 and P2Y12 (zeige P2RY12 Proteine) heterodimer internalization/endocytosis is required for beta-arrestin-2 (zeige ARRB2 Proteine) recruitment to endosomes and up-regulation of Akt (zeige AKT1 Proteine) signaling; activation of PAR4 but not of P2Y12 (zeige P2RY12 Proteine) drives internalization of the PAR4-P2Y12 (zeige P2RY12 Proteine) heterodimer. (PAR4 = protease-activated receptor 4 (zeige F2RL3 Proteine); P2Y12 (zeige P2RY12 Proteine) = purinergic receptor P2Y (zeige P2RY1 Proteine), G-protein coupled, 12 protein; Akt (zeige AKT1 Proteine) = proto-oncogene (zeige RAB1A Proteine) protein c (zeige PROC Proteine)-akt (zeige AKT1 Proteine))

  6. In this review, we will focus on the therapeutic perspective of Par-4 with a special reference to its (Par-4) virgin prospect of devastating metastasis control.

  7. in vitro and in vivo upregulation of Par-4 expression is indispensable for the trafficking of GRP78 (zeige HSPA5 Proteine) to the cell membrane and subsequent apoptosis of cancer cell

  8. Prostate apoptosis response 4 (PAR4) expression modulates WNT (zeige WNT2 Proteine) signaling pathways in MCF7 breast cancer cells: A possible mechanism underlying PAR4-mediated docetaxel chemosensitivity.

  9. Decreased PAR4 expression in breast cancer is associated with shorter survival. PAR4 suppresses growth and invasiveness of breast cancer cells.

  10. Authors determined that PAR-4 induces cell apoptosis in response to stimuli, in vitro, but is also involved in the relocation of GRP78 (zeige HSPA5 Proteine) from endoplasmic reticulum to the cell surface of ovarian cancer cell line.

Mouse (Murine) PRKC, Apoptosis, WT1, Regulator (PAWR) Interaktionspartner

  1. Findings reveal a novel role for Par-4 (zeige F2RL3 Proteine)/NF-kappaB (zeige NFKB1 Proteine) in islet beta cell apoptosis and type 2 diabetes.

  2. Par4 (zeige F2RL3 Proteine), CEBPB (zeige CEBPB Proteine) and FAK (zeige PTK2 Proteine) form a senescence signaling pathway, playing roles in modulating cell survival, growth, apoptosis, EMT (zeige ITK Proteine) and self-renewal

  3. a novel mechanism of apoptosis induction by PAR-4 (zeige F2RL3 Proteine)/ceramide-enriched exosomes, which may critically contribute to Alzheimer disease.

  4. extracellular Par-4 (zeige F2RL3 Proteine)/SAC (zeige ADCY10 Proteine) is systemically functional in inhibition of tumor growth and metastasis progression.

  5. loss of PAR4 (zeige F2RL3 Proteine) leads to a reduction in the ability of tumour necrosis factor-alpha (zeige TNF Proteine) to induce apoptosis by increased activation of NF-kappaB (zeige NFKB1 Proteine)

  6. Antisense knockdown of PAR-4 (zeige F2RL3 Proteine) or inhibition of ceramide biosynthesis reduced stem cell apoptosis; PAR-4 (zeige F2RL3 Proteine) overexpression and treatment with ceramide analogs elevated apoptosis.

  7. AATF (zeige AATF Proteine) is an endogenous antagonist of Par-4 (zeige F2RL3 Proteine) activity and an effective inhibitor of aberrant amyloid beta 1-42 production and secretion under apoptotic conditions.

  8. Par-4 is directly involved in regulating choline uptake by interacting with CHT1 and by reducing its incorporation on the cell surface

  9. the mechanism for Ras-mediated down-regulation of Par-4 (zeige F2RL3 Proteine) is by promoter methylation

  10. direct physical association with ceramide and PAR-4 (zeige F2RL3 Proteine) regulates the activity of PKCzeta (zeige PRKCZ Proteine)

PAWR Protein Überblick

Protein Überblick

The tumor suppressor WT1 represses and activates transcription. The protein encoded by this gene is a WT1-interacting protein that itself functions as a transcriptional repressor. It contains a putative leucine zipper domain which interacts with the zinc finger DNA binding domain of WT1. This protein is specifically upregulated during apoptosis of prostate cells.

Genbezeichner und Symbole assoziert mit PAWR

  • pro-apoptotic WT1 regulator (PAWR)
  • PRKC, apoptosis, WT1, regulator L homeolog (pawr.L)
  • PRKC, apoptosis, WT1, regulator (pawr)
  • pro-apoptotic WT1 regulator (Pawr)
  • PRKC, apoptosis, WT1, regulator (Pawr)
  • 2310001G03Rik Protein
  • MGC81382 Protein
  • Par-4 Protein
  • Par4 Protein
  • PAWR Protein
  • pawrl Protein
  • zgc:103513 Protein

Bezeichner auf Proteinebene für PAWR

PRKC, apoptosis, WT1, regulator , PAR-4 , PRKC apoptosis WT1 regulator protein , PRKC, apoptosis, WT1, regulator like , WT1-interacting protein , prostate apoptosis response 4 protein , prostate apoptosis response protein 4 , prostate apoptosis response protein PAR-4 , prostate apoptosis response-4 , transcriptional repressor PAR4 , Prostate apoptosis response protein 4 , par-4 induced by effectors of apoptosis , transcriptional repressor Par-4-like protein PAWR

417870 Gallus gallus
447443 Xenopus laevis
449994 Danio rerio
452094 Pan troglodytes
532789 Bos taurus
695617 Macaca mulatta
5074 Homo sapiens
64513 Rattus norvegicus
114774 Mus musculus
611487 Canis lupus familiaris
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