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POU3F2 encodes a member of the POU-III class of neural transcription factors. Zusätzlich bieten wir Ihnen POU3F2 Proteine (8) und POU3F2 Kits (3) und viele weitere Produktgruppen zu diesem Protein an.
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Human Monoclonal POU3F2 Primary Antibody für ELISA, WB - ABIN1098110
Goodall, Carreira, Denat, Kobi, Davidson, Nuciforo, Sturm, Larue, Goding: Brn-2 represses microphthalmia-associated transcription factor expression and marks a distinct subpopulation of microphthalmia-associated transcription factor-negative melanoma cells. in Cancer research 2008
Show all 2 Pubmed References
Human Monoclonal POU3F2 Primary Antibody für ELISA, WB - ABIN562322
Hu, Matsui, Gagnon, Schwartz, Gabillet, Arar, Wu, Bezprozvanny, Corey: Allele-specific silencing of mutant huntingtin and ataxin-3 genes by targeting expanded CAG repeats in mRNAs. in Nature biotechnology 2009
Human Polyclonal POU3F2 Primary Antibody für ELISA, WB - ABIN4346884
Cabos-Siguier, Steunou, Joseph, Alazard, Ducoux-Petit, Nieto, Monsarrat, Erard, Clottes: Expression and purification of human full-length N Oct-3, a transcription factor involved in melanoma growth. in Protein expression and purification 2008
Re4sults show that BRN2 is: directly transcriptionally repressed by AR, required for the expression of terminal neuroendocrine markers and aggressive growth of castration-resistant prostate cancer (CRPC), and is highly expressed in human neuroendocrine prostate cancer and metastatic CRPC with low circulating PSA.
These findings not only shed light on the molecular mechanism of the anticancer properties of capsaicin, but also the transcription regulation of tNOX (zeige ENOX2 Antikörper) expression that may potentially explain how POU3F2 is associated with tumorigenesis.
Data indicate that NFIB (zeige NFIB Antikörper) protein increases EZH2 (zeige EZH2 Antikörper) protein expression downstream of BRN2 protein, which further decreases MITF (zeige MITF Antikörper) protein levels.
We show that POU3F2 lies downstreamof SIM1 and controls oxytocin expression in the hypoth (zeige SIM1 Antikörper)alamic neuroendocrine preoptic area. We show that this finding is consistent with the expression patterns of POU3F2 and related genes in the human brain.
BRN2 is a higher level regulator than ASCL1 and ND1 and BRN2 might be involved in aggressiveness of small cell lung cancer.
TTF1 expression in small-cell lung cancer is a cell lineage-specific phenomenon that involves the developing neural cell-specific homeoprotein BRN2.
The present study investigated transcriptional regulation of CDH13 (zeige CDH13 Antikörper) in melanoma. Found an inverse correlation between BRN2 and T-cadherin (zeige CDH13 Antikörper) protein and transcript expression in melanoma.
PI3K (zeige PIK3CA Antikörper) has a crucial role in regulating Brn-2 and Pax3 (zeige PAX3 Antikörper) expression and neoplasm invasiveness, and it is a key determinant of melanoma subpopulation diversity.
links BRN2 as an activator and MITF (zeige MITF Antikörper) as a repressor of the NOTCH (zeige NOTCH1 Antikörper) pathway in melanoma cells. Loss of the BRN2-MITF (zeige MITF Antikörper) axis in antisense-ablated cell lines decreased the melanoma sphere-forming capability and cell adhesion
a model for the apparent non-overlapping expression levels of BRN2 and MITF (zeige MITF Antikörper) in melanoma, mediated by miR (zeige MLXIP Antikörper)-211 expression.
This study investigated changes in the skin in the K5-Brn2 transgenic mouse, which overexpresses Brn2 and contains the keratin 5 promotor. The volume of the eccrine glands was reduced in the K5-Brn2 transgenic mouse.
results suggest that a mutually repressive mechanism exists between Brn1 (zeige POU3F3 Antikörper)/2 and Rorb (zeige RORB Antikörper) expression and that the established expression of Brn1 (zeige POU3F3 Antikörper)/2 and Rorb (zeige RORB Antikörper) further specifies those neurons into L2/3 and L4, respectively, during UCP (zeige UCP1 Antikörper) maturation
Mammalian-specific sequences in pou3f2 contribute to maternal behavior.
Brn2-Zic1 (zeige ZIC1 Antikörper) axis is essential to specify neural fate in retinoic-acid-treated embryonic stem cells.
Brn2 predominantly forms homodimers on MORE cis (zeige CISH Antikörper) elements in NS5 (zeige RAF1 Antikörper) mouse neural stem cells
This study showed that Sox (zeige QSOX1 Antikörper)/Pou cis (zeige CISH Antikörper)-regulatory logics and heterogeneity of cortical progenitors in the the mouse embryonic cerebral cortex.
Onset of Pou3f2 expression occurs in ventricular zone progenitors, and that Pou3f2 subsequently label neural progeny switching from deep-layer Ctip2 (zeige BCL11B Antikörper)+ identity to Satb2 (zeige SATB2 Antikörper)+ upper-layer fate as they migrate to proper superficial positions.
Our findings have important implications for understanding lineage specification and somatic cell reprogramming, where SOX2, OCT4, and BRN2 have been shown to be key factors
Melanocyte migration and proliferation are controlled both through the regulation of Pax3 by nonphosphorylated Brn2 and through the regulation of MITF-M by the overall BRN2 level.
In the brains of Huntington's disease model mice, Brn-2 loses its function through two pathways, its sequestration by mutant huntingtin (zeige HTT Antikörper) and its reduced transcription, leading to reduced expression of hypothalamic neuropeptides.
Using morpholino and mutant zebrafish models, we show that POU3F2 lies downstream of SIM1 and controls oxytocin expression in the hypothalamic neuroendocrine preoptic area.
This gene encodes a member of the POU-III class of neural transcription factors. The encoded protein is involved in neuronal differentiation and enhances the activation of corticotropin-releasing hormone regulated genes. Overexpression of this protein is associated with an increase in the proliferation of melanoma cells.
POU domain, class 3, transcription factor 2
, brain-specific homeobox/POU domain protein 2
, nervous system-specific octamer-binding transcription factor N-Oct-3
, octamer-binding protein 7
, octamer-binding transcription factor 7
, POU domain, class 3, transcription factor 2-B
, POU domain, class 3, transcription factor 4
, transcription factor POU3-B
, brain-2 class III POU-domain protein
, protein Brn-2
, POU class 3 homeobox 2
, POU domain gene 47
, POU domain protein 47
, POU domain protein ZP-47
, LOW QUALITY PROTEIN: POU domain, class 3, transcription factor 2