PHD Finger Protein 8 Proteine (PHF8)

The protein encoded by PHF8 is a histone lysine demethylase that preferentially acts on histones in the monomethyl or dimethyl states. Zusätzlich bieten wir Ihnen PHF8 Antikörper (33) und PHF8 Kits (6) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
PHF8 320595 Q80TJ7
PHF8 23133 Q9UPP1
Ratte PHF8 PHF8 317425  
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Showing 4 out of 4 products:

Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Insektenzellen Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 70 Days
Insektenzellen Maus His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 70 Days
Baculovirus Human DYKDDDDK Tag PHF8 activity assay. Recombinant PHF8 activity measured using a demethylation assay. MALDI-TOF was used for detection. Recombinant PHF8 protein gel. PHF8 protein was run on a 10% SDS-PAGE gel and stained with Coomassie blue. 20 μg Anmelden zum Anzeigen 1 bis 2 Tage
Escherichia coli (E. coli) Maus T7 tag,His tag 100 μg Anmelden zum Anzeigen 15 bis 18 Tage

PHF8 Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Mouse (Murine) ,
Human ,

Weitere Proteine zu PHD Finger Protein 8 (PHF8) Interaktionspartnern

Human PHD Finger Protein 8 (PHF8) Interaktionspartner

  1. Knockdown or knockout of PHF8 by RNAi or CRISPR-Cas9 system reduced the activation of HIF1alpha (zeige HIF1A Proteine).

  2. USP7 (zeige USP7 Proteine) promotes breast carcinogenesis by stabilizing PHF8 and upregulating cyclin A2 (zeige CCNA2 Proteine). and the interaction between USP7 (zeige USP7 Proteine) and PHF8 is augmented during DNA damage.

  3. PHF8 reduces the H3K9me2 level at the E2F4 (zeige E2F4 Proteine) transcriptional start site, demonstrating a direct function of PHF8 in endothelial E2F4 (zeige E2F4 Proteine) gene regulation

  4. PHF2 (zeige PHF1 Proteine) is likely to repress rDNA transcription by competing with PHF8 for binding of ribosomal DNA promoter and by recruiting H3K9me2/3 methyltransferase SUV39H1 (zeige SUV39H1 Proteine).

  5. PHF8 promotes lung cancer cell growth and survival by regulating miR (zeige MLXIP Proteine)-21.

  6. knockdown of PHF8 led to a reduction in the number of migratory and invasive cells. Furthermore, downregulation of PHF8 attenuated the tumorigenicity of ESCC cells in vivo.

  7. PHF8 is regulated by APC (zeige APC Proteine)(cdc20 (zeige CDC20 Proteine)) and plays an important role in the G2/M transition.

  8. study identified the histone demethylase (zeige MBD2 Proteine) PHF8 as a coactivator that is specifically recruited by RAR-alpha (zeige RARA Proteine) fusions to activate expression of their downstream targets upon all-trans retinoic acid treatment in acute promyelocytic leukemia (zeige PML Proteine)

  9. Results show that PHF8 controls the expression of genes involved in cell adhesion and cytoskeleton organization such as RhoA, Rac1 and GSK3beta.

  10. a role of PHF8 in cell migration and invasion

Mouse (Murine) PHD Finger Protein 8 (PHF8) Interaktionspartner

  1. knockdown of pmaip1 (zeige PMAIP1 Proteine) mimicked the phenotype of ph8(-/Y) by showing the decreased apoptosis during early differentiation of embryonic stem cells and promoted mesodermal and cardiac commitment.

  2. PHF8 overexpression reversed cardiac dysfunction, hypertrophy and fibrosis upon pressure overload in PHF8 transgenic mice.

  3. The gene knockdown of PHF8 in mouse embryonic carcinoma P19 cells impairs RA-induced neuronal differentiation.

  4. an important function of PHF8 is in midline formation and in the development of cognitive abilities, and may have a role in X linked mental retardation associated with cleft lip/palate

Zebrafish PHD Finger Protein 8 (PHF8) Interaktionspartner

  1. PHF8 regulates zebrafish neuronal cell survival and jaw development in part by directly regulating the expression of the homeodomain transcription factor MSX1/MSXB, which functions downstream of multiple signalling and developmental pathways

PHF8 Protein Überblick

Protein Überblick

The protein encoded by this gene is a histone lysine demethylase that preferentially acts on histones in the monomethyl or dimethyl states. The encoded protein requires Fe(2+) ion, 2-oxoglutarate, and oxygen for its catalytic activity. Defects in this gene are a cause of mental retardation syndromic X-linked Siderius type (MRXSSD). Four transcript variants encoding different isoforms have been found for this gene.

Genbezeichner und Symbole assoziert mit PHD Finger Protein 8 Proteine (PHF8)

  • PHD finger protein 8 (Phf8)
  • PHD finger protein 8 (PHF8)
  • PHD finger protein 8 (phf8)
  • 9830141C09Rik Protein
  • JHDM1F Protein
  • mKIAA1111 Protein
  • MRXSSD Protein
  • RGD1561065 Protein
  • ZNF422 Protein
  • zPHF8 Protein

Bezeichner auf Proteinebene für PHD Finger Protein 8 Proteine (PHF8)

histone lysine demethylase PHF8 , jumonji C domain-containing histone demethylase 1F

320595 Mus musculus
23133 Homo sapiens
317425 Rattus norvegicus
491897 Canis lupus familiaris
513959 Bos taurus
100520413 Sus scrofa
566534 Danio rerio
100344764 Oryctolagus cuniculus
100060410 Equus caballus
Ausgewählte Anbieter für PHF8 Proteine (PHF8)
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