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The protein encoded by PHF8 is a histone lysine demethylase that preferentially acts on histones in the monomethyl or dimethyl states. Zusätzlich bieten wir Ihnen PHF8 Antikörper (33) und PHF8 Kits (6) und viele weitere Produktgruppen zu diesem Protein an.
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Knockdown or knockout of PHF8 by RNAi or CRISPR-Cas9 system reduced the activation of HIF1alpha (zeige HIF1A Proteine).
USP7 (zeige USP7 Proteine) promotes breast carcinogenesis by stabilizing PHF8 and upregulating cyclin A2 (zeige CCNA2 Proteine). and the interaction between USP7 (zeige USP7 Proteine) and PHF8 is augmented during DNA damage.
PHF8 reduces the H3K9me2 level at the E2F4 (zeige E2F4 Proteine) transcriptional start site, demonstrating a direct function of PHF8 in endothelial E2F4 (zeige E2F4 Proteine) gene regulation
PHF2 (zeige PHF1 Proteine) is likely to repress rDNA transcription by competing with PHF8 for binding of ribosomal DNA promoter and by recruiting H3K9me2/3 methyltransferase SUV39H1 (zeige SUV39H1 Proteine).
PHF8 promotes lung cancer cell growth and survival by regulating miR (zeige MLXIP Proteine)-21.
knockdown of PHF8 led to a reduction in the number of migratory and invasive cells. Furthermore, downregulation of PHF8 attenuated the tumorigenicity of ESCC cells in vivo.
PHF8 is regulated by APC (zeige APC Proteine)(cdc20 (zeige CDC20 Proteine)) and plays an important role in the G2/M transition.
study identified the histone demethylase (zeige MBD2 Proteine) PHF8 as a coactivator that is specifically recruited by RAR-alpha (zeige RARA Proteine) fusions to activate expression of their downstream targets upon all-trans retinoic acid treatment in acute promyelocytic leukemia (zeige PML Proteine)
Results show that PHF8 controls the expression of genes involved in cell adhesion and cytoskeleton organization such as RhoA, Rac1 and GSK3beta.
a role of PHF8 in cell migration and invasion
knockdown of pmaip1 (zeige PMAIP1 Proteine) mimicked the phenotype of ph8(-/Y) by showing the decreased apoptosis during early differentiation of embryonic stem cells and promoted mesodermal and cardiac commitment.
PHF8 overexpression reversed cardiac dysfunction, hypertrophy and fibrosis upon pressure overload in PHF8 transgenic mice.
The gene knockdown of PHF8 in mouse embryonic carcinoma P19 cells impairs RA-induced neuronal differentiation.
an important function of PHF8 is in midline formation and in the development of cognitive abilities, and may have a role in X linked mental retardation associated with cleft lip/palate
PHF8 regulates zebrafish neuronal cell survival and jaw development in part by directly regulating the expression of the homeodomain transcription factor MSX1/MSXB, which functions downstream of multiple signalling and developmental pathways
The protein encoded by this gene is a histone lysine demethylase that preferentially acts on histones in the monomethyl or dimethyl states. The encoded protein requires Fe(2+) ion, 2-oxoglutarate, and oxygen for its catalytic activity. Defects in this gene are a cause of mental retardation syndromic X-linked Siderius type (MRXSSD). Four transcript variants encoding different isoforms have been found for this gene.
histone lysine demethylase PHF8
, jumonji C domain-containing histone demethylase 1F