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PHF1 encodes a Polycomb group protein.
Showing 3 out of 4 products:
the increase of DNA accessibility within the H3K36me3-containing nucleosome, instigated by the Tudor domain of PHF1 binding to H3K36me3, is dramatically enhanced by the PHF1 N-terminal domain.
ZC3H7B-BCOR (zeige BCOR Proteine) and MEAF6 (zeige MEAF6 Proteine)-PHF1 fusions occurred predominantly in S100 protein-negative and malignant OFMT.
the F61L/S86F mutant of MTF2 (zeige MTF2 Proteine) Tudor-PHD1 (zeige EGLN2 Proteine) was able to bind to H3K36me3 as strong as the PHF1 Tudor bound to this PTM . We concluded that the hydrophobic patch plays an essential role in binding of these Tudors to methylated chromatin
PCL1 binds to and stabilizes p53 (zeige TP53 Proteine) to induce cellular quiescence
full-length PHF1 in HEK293 cells co-localizes with histone K27me3, but not with K36me3, and this co-localization depends on the trimethyllysine binding pocket indicating that K27me3 is an in vivo target for the PHF1 Tudor domain
present two more ESS with MEAF6 (zeige MEAF6 Proteine)/PHF1 detected by transcriptome sequencing (case 1) and RT-PCR (case 2), proving that this fusion is recurrent in ESS
Underscore the likely importance of PHF1 rearrangements in the pathogenesis of ossifying fibromyxoid tumors of soft parts.
Morphological features, immunoprofile and fluorescence in situ hybridization rearrangements of JAZF1 (zeige JAZF1 Proteine) and PHF1 genes were correlated with tumor category and outcome in endometrial sarcomas
The histone H3K36me3 binding by the Tudor domains of PHF1, PHF19 (zeige PHF19 Proteine) and likely MTF2 (zeige MTF2 Proteine) provide another recruitment and regulatory mechanism for the PRC2 complex.
All endometrial stromal sarcomas showing sex cords had PHF1 genetic rearrangement, suggesting that such rearrangements may induce sex cord differentiation.
This gene encodes a Polycomb group protein. The protein is a component of a histone H3 lysine-27 (H3K27)-specific methyltransferase complex, and functions in transcriptional repression of homeotic genes. The protein is also recruited to double-strand breaks, and reduced protein levels results in X-ray sensitivity and increased homologous recombination. Multiple transcript variants encoding different isoforms have been found for this gene.
PHD finger protein 1
, polycomblike PCL1
, PHD finger protein 1-like
, polycomb-like protein 1
, tudor domain containing 19C
, t-complex testis-expressed 3
, T-complex testis-expressed 3
, polycomb-like 1