PHD Finger Protein 1 Proteine (PHF1)

PHF1 encodes a Polycomb group protein. Zusätzlich bieten wir Ihnen PHF1 Antikörper (59) und PHF1 Kits (5) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
PHF1 5252 O43189
PHF1 21652 Q9Z1B8
Ratte PHF1 PHF1 294287  
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Katalog Nr. Origin Quelle Konjugat Bilder Menge Lieferzeit Preis Details
Insektenzellen Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg 60 Days
Insektenzellen Maus His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg 60 Days
Wheat germ Human GST tag 2 μg 11 bis 12 Tage

PHF1 Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Human ,
Mouse (Murine)

Weitere Proteine zu PHD Finger Protein 1 (PHF1) Interaktionspartnern

Human PHD Finger Protein 1 (PHF1) Interaktionspartner

  1. PHF1 promotes cell proliferation, invasion, and tumorigenesis in vivo and in vitro and its expression is markedly upregulated in a variety of human cancers

  2. the increase of DNA accessibility within the H3K36me3-containing nucleosome, instigated by the Tudor domain of PHF1 binding to H3K36me3, is dramatically enhanced by the PHF1 N-terminal domain.

  3. ZC3H7B-BCOR and MEAF6-PHF1 fusions occurred predominantly in S100 protein-negative and malignant OFMT.

  4. the F61L/S86F mutant of MTF2 Tudor-PHD1 was able to bind to H3K36me3 as strong as the PHF1 Tudor bound to this PTM . We concluded that the hydrophobic patch plays an essential role in binding of these Tudors to methylated chromatin

  5. PCL1 binds to and stabilizes p53 to induce cellular quiescence

  6. full-length PHF1 in HEK293 cells co-localizes with histone K27me3, but not with K36me3, and this co-localization depends on the trimethyllysine binding pocket indicating that K27me3 is an in vivo target for the PHF1 Tudor domain

  7. present two more ESS with MEAF6/PHF1 detected by transcriptome sequencing (case 1) and RT-PCR (case 2), proving that this fusion is recurrent in ESS

  8. Underscore the likely importance of PHF1 rearrangements in the pathogenesis of ossifying fibromyxoid tumors of soft parts.

  9. PHF1b may be a molecular transducer of GABA A receptor function and thus GABA-mediated neurotransmission in the central nervous system.

  10. Morphological features, immunoprofile and fluorescence in situ hybridization rearrangements of JAZF1 and PHF1 genes were correlated with tumor category and outcome in endometrial sarcomas

  11. The histone H3K36me3 binding by the Tudor domains of PHF1, PHF19 and likely MTF2 provide another recruitment and regulatory mechanism for the PRC2 complex.

  12. All endometrial stromal sarcomas showing sex cords had PHF1 genetic rearrangement, suggesting that such rearrangements may induce sex cord differentiation.

  13. Polycomb group protein PHF1 regulates p53-dependent cell growth arrest and apoptosis

  14. findings suggest that PHF1 can mediate deposition of the repressive H3K27me3 mark and acts as a cofactor in early DNA-damage response

  15. findings show that the interaction of Phf19 with H3K36me2 and H3K36me3 is essential for PRC2 complex activity and for proper regulation of gene repression in embryonic stem cells

  16. The PHF1 gene, previously shown to be the 3'-partner of fusion genes in endometrial stromal tumors, is also recurrently involved in the pathogenesis of ossifying fibromyxoid tumors.

  17. The role of PHF1 in H3K27 methylation and Hox gene silencing is reported.

  18. PHF1 modulates the activity of Ezh2 in favor of the repressive H3K27me3 mark

  19. PHF1 interacts physically with Ku70/Ku80, suggesting that PHF1 promotes nonhomologous end-joining processes.

PHF1 Protein Überblick

Protein Überblick

This gene encodes a Polycomb group protein. The protein is a component of a histone H3 lysine-27 (H3K27)-specific methyltransferase complex, and functions in transcriptional repression of homeotic genes. The protein is also recruited to double-strand breaks, and reduced protein levels results in X-ray sensitivity and increased homologous recombination. Multiple transcript variants encoding different isoforms have been found for this gene.

Genbezeichner und Symbole assoziert mit PHD Finger Protein 1 Proteine (PHF1)

  • PHD finger protein 1 L homeolog (phf1.L)
  • PHD finger protein 1 (PHF1)
  • PHD finger protein 1 (Phf1)
  • AW557215 Protein
  • D17Ertd455e Protein
  • hPHF1 Protein
  • mPcl1 Protein
  • MTF2L2 Protein
  • PCL1 Protein
  • PHF2 Protein
  • Tctex-3 Protein
  • Tctex3 Protein
  • TDRD19C Protein
  • xpcl1 Protein

Bezeichner auf Proteinebene für PHD Finger Protein 1 Proteine (PHF1)

PHD finger protein 1 , polycomblike PCL1 , PHD finger protein 1-like , hPCl1 , polycomb-like protein 1 , tudor domain containing 19C , t-complex testis-expressed 3 , T-complex testis-expressed 3 , polycomb-like 1

398142 Xenopus laevis
718337 Macaca mulatta
100346719 Oryctolagus cuniculus
100402318 Callithrix jacchus
100459635 Pongo abelii
100472996 Ailuropoda melanoleuca
5252 Homo sapiens
481741 Canis lupus familiaris
508957 Bos taurus
21652 Mus musculus
294287 Rattus norvegicus
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