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PDZK1 encodes a PDZ domain-containing scaffolding protein. Zusätzlich bieten wir Ihnen PDZK1 Antikörper (119) und PDZK1 Proteine (7) und viele weitere Produktgruppen zu diesem Protein an.
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PDZK1 directly interacts with OATP2B1 resulting in a change of the amount of transporter in the membrane, and thereby in an increased transport function.
These findings have provided first lines of evidences that PDZK1 expression is negatively correlated with SHP-1 activation and poor clinical outcomes in clear cell renal cell carcinoma (ccRCC) . PDZK1 was identified as a novel tumor suppressor in ccRCC by negating SHP-1 activity
HNF1alpha (zeige HNF1A ELISA Kits), which has previously been described as a modulator of several transporters of the renal transportosome, is also a key determinant of PDZK1 transcription.
a PDZK1 single nucleotide polymorphism rs12129861 was found to be significantly associated with gout susceptibility (meta-analysis)
PDZK1 was defined as an independent prognostic factor for both OS and DFS (zeige FST ELISA Kits). These findings indicated that low level of PDZK1 could predict poor clinical outcome in patients with ccRCC.
Inflammation-induced loss of PDZK1 expression may contribute to the NHE3 (zeige SLC9A3 ELISA Kits) dysfunction observed in the inflamed intestine.
PARP (zeige COL11A2 ELISA Kits) regulates estradiol-mediated cell growth by controlling the ER/IGF-1R (zeige IGF1R ELISA Kits)/PDZK1 axis.
PDZK1, negatively regulates 5-HT2AR endocytosis and has no effect upon 5-HT2AR-mediated ERK1/2 (zeige MAPK1/3 ELISA Kits) phosphorylation.
Described is a structure of D-AKAP2 (zeige AKAP10 ELISA Kits) in complex with two interacting partners and the exact mechanism by which a segment that on its own is disordered presents an alpha-helix to PKA and a beta-strand to PDZK1.
PDZK1 and NHERF1 regulate the transport function of OATP1A2 by modulating protein internalization via a clathrin-dependent pathway and by enhancing protein stability.
Dysfunction of intestinal OCTN1 (zeige SLC22A4 ELISA Kits) in mouse model of chronic kidney disease (CKD) impaired the OCTN1 (zeige SLC22A4 ELISA Kits)-ergothioneine axis, an adaptive antioxidant system, and that decreased antioxidant ergothioneine levels may contribute to CKD progression in a PDZK1-dependent manner.
These results suggest that the PDZ domain of PICK1 (zeige PICK1 ELISA Kits) directly interacts with calcineurin B (zeige CAN ELISA Kits) in osteoclast progenitor cells and promotes osteoclast differentiation through activation of calcineurin-NFAT (zeige NFATC1 ELISA Kits) signaling.
PDZK1 has novel SR-BI (zeige SCARB1 ELISA Kits)-independent function in VSM that affords protection from neointima formation, and this involves PDZK1 suppression of VSM cell proliferation via an inhibitory interaction with Bcr (zeige BCR ELISA Kits)
Data show that interaction of the inducible nitric oxide synthase (iNOS (zeige NOS2 ELISA Kits)) C-terminus with the PDZ domains of EBP50 protein or Pdzk1 protein CAP70 resulted greater nitric oxide (NO) synthesis.
PDZK1 regulates intracellular trafficking of Oatp1a1 (zeige Slco1a1 ELISA Kits).
PDZK1(NHERF3) is entirely non-raft associated with lipid rafts in brush border membrane fractions of NHE3 (zeige SLC9A3 ELISA Kits).
NHERF3 is a key regulator of organic transport in the kidney, particularly MRP4-mediated clearance of drug molecules.
SR-BI (zeige SCARB1 ELISA Kits) and PDZK1 protein and mRNA expression levels fell rapidly in primary hepatocyte cultures, indicating this system does not adequately mimic hepatocytes in vivo for analysis of the PDZK1 dependence of SR-BI (zeige SCARB1 ELISA Kits).
the localization of PDZK1 on hepatocyte cell surface membranes in vivo is dependent on its PDZ4 domain and the presence of SR-BI (zeige SCARB1 ELISA Kits).
This gene encodes a PDZ domain-containing scaffolding protein. PDZ domain-containing molecules bind to and mediate the subcellular localization of target proteins. The encoded protein mediates the localization of cell surface proteins and plays a critical role in cholesterol metabolism by regulating the HDL receptor, scavenger receptor class B type 1. Single nucleotide polymorphisms in this gene may be associated with metabolic syndrome, and overexpression of this gene may play a role in drug resistance of multiple myeloma. Pseudogenes of this gene are located on the long arm of chromosome 1. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
PDZ domain containing 1
, Na(+)/H(+) exchange regulatory cofactor NHE-RF3-like
, CFTR-associated protein of 70 kDa
, Na(+)/H(+) exchange regulatory cofactor NHE-RF3
, PDZ-containing kidney protein 1
, na/Pi cotransporter C-terminal-associated protein 1
, sodium-hydrogen exchanger regulatory factor 3
, Na(+)/H(+) exchanger regulatory factor 3
, PDZ domain-containing protein 1
, PDZK1-like protein
, C-terminal linking and modulating protein
, C-terminal-linking and modulating protein
, dietary Pi-regulated RNA-1