P21 Protein (Cdc42/Rac)-Activated Kinase 7 Proteine (PAK7)

Human P21 Protein (Cdc42/Rac)-Activated Kinase 7 (PAK7) Interaktionspartner

1. Mechanistic studies demonstrated that miR-106a-5p directly bound to the 3'-UTR of the PAK5 mRNA and mediated a decrease in the protein expression of PAK5.

2. PAK5 (zeige PAK6 Proteine)-mediated phosphorylation and nuclear translocation of NF-kappaB (zeige NFKB1 Proteine)-p65 (zeige GORASP1 Proteine) promotes breast cancer cell proliferation in vitro and in vivo

3. p21-activated kinase (PAK7) was identified as the putative target of miR492 in osteosarcoma (OS), and we further found a significantly inverse correlation between PAK7 and miR492 in OS specimens.

4. As PAK7 has been implicated in the progression of various tumor types, silencing the expression of PAK7 via pairing with miR526a may be an effective strategy in tumor suppression.

5. These findings indicate that aberrant PAK7 expression is associated with the occurrence of metastasis and poor clinical outcomes of human colon cancer by promoting the epithelial to mesechymal transition

6. Data suggest expression of ECAD (E-cadherin (zeige CDH1 Proteine)) in bladder cancer cell lines correlates with presence of intercellular junctions and level of PAK5 (zeige PAK6 Proteine) (p21 (zeige CDKN1A Proteine)-activated kinase PAK5 (zeige PAK6 Proteine) protein) expression; endogenous PAK5 (zeige PAK6 Proteine) is localized to intercellular junctions and interacts with ECAD (zeige CDH1 Proteine); depletion of PAK5 (zeige PAK6 Proteine) expression reduces integrity of intercellular junctions; PAK5 (zeige PAK6 Proteine) mRNA levels are reduced in bladder cancer compared with normal controls.

7. model suggests PAK5 self-association interferes with AID binding to the catalytic domain, thus maintaining its high activity.

8. PAK7 expression is significantly downregulated in human masticatory mucosa during wound healing

9. PAK7 is overexpressed in human esophageal squamous cell cancer samples and correlated with lymph node metastasis.

10. E47 (zeige TCF3 Proteine) is a novel substrate of PAK5 (zeige PAK6 Proteine), and PAK5 (zeige PAK6 Proteine)-mediated phosphorylation of E47 (zeige TCF3 Proteine) promotes epithelial-mesenchymal transition and metastasis of colon cancer.

Xenopus laevis P21 Protein (Cdc42/Rac)-Activated Kinase 7 (PAK7) Interaktionspartner

1. Xenopus PAK5 regulates convergent extension movements in vivo by modulating the calcium-mediated cell-cell adhesion in blastomeres.

Mouse (Murine) P21 Protein (Cdc42/Rac)-Activated Kinase 7 (PAK7) Interaktionspartner

1. PAK-7 p21-activated kinase 5 knockout mice are more sensitive to the stimulant effects of amphetamine

2. functional deficits in PAK5, PAK6 (zeige PAK6 Proteine) and PAK5/PAK6 (zeige PAK6 Proteine) knockout mice

3. PAK 5 is involved in formalin-induced inflammatory nociception through regulation of MAPK-induced c-Fos-activation and formalin-specific transient receptor potential-channels.

4. These results implicate Pak5 in Pacsin1 (zeige PACSIN1 Proteine)- and Synaptojanin1-mediated synaptic vesicle trafficking.

5. PAK5 may provide a molecular rationale for late-stage complications in diabetes.

6. Our results indicate that Pak5 and Pak6 (zeige PAK6 Proteine) together are not required for viability, but are required for a normal level of locomotion and activity as well as for learning and memory.