Osteopetrosis Associated Transmembrane Protein 1 (OSTM1) ELISA Kits

OSTM1 encodes a protein that may be involved in the degradation of G proteins via the ubiquitin-dependent proteasome pathway. Zusätzlich bieten wir Ihnen OSTM1 Antikörper (61) und OSTM1 Proteine (12) und viele weitere Produktgruppen zu diesem Protein an.

list all ELISA KIts Gen GeneID UniProt
OSTM1 28962 Q86WC4
OSTM1 14628 Q8BGT0
Anti-Ratte OSTM1 OSTM1 499474  
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Showing 2 out of 4 products:

Katalog Nr. Reaktivität Sensitivität Bereich Bilder Menge Lieferzeit Preis Details
Human < 0.094 ng/mL 0.156 ng/mL - 10 ng/mL   96 Tests 11 bis 18 Tage
$838.60
Details
Maus < 0.094 ng/mL 0.156 ng/mL - 10 ng/mL   96 Tests 11 bis 18 Tage
$838.60
Details

Weitere ELISA Kits für OSTM1 Interaktionspartner

Human Osteopetrosis Associated Transmembrane Protein 1 (OSTM1) Interaktionspartner

  1. Homozygous splice defect in OSTM1, coexisting with MANEAL mutation was identified in a patient with neurological disorder with brain iron accumulation.

  2. KIF5B is essential for Ostm1 intracellular dispersion.

  3. Ostm1 has a primary and autonomous role in neuronal homeostasis

  4. Common gating underlies the slow voltage activation of ClC-7.

  5. we describe for the first time homozygous microdeletions of different sizes affecting the OSTM1 gene in two unrelated consanguineous families with children suffering from neuronopathic infantile malignant osteopetrosi

  6. The authors show that both the aminoterminus and transmembrane span of the Ostm1 beta-subunit are required for ClC-7 Cl(-)/H(+)-exchange, whereas the Ostm1 transmembrane domain suffices for its ClC-7-dependent trafficking to lysosomes.

  7. mutation in the human GL gene leads to severe recessive osteopetrosis

  8. The human GIPN gene has 6 exons and 5 introns, and encodes a 334-aa protein.

  9. A novel mutation affecting the OSTM1 locus responsible for ARO. In addition to common clinical features of osteopetrosis, the patient developed a unique neuronal pathology that provided evidence for the role of OSTM1 in normal neuronal cell development.

  10. This study reports on a 12-month-old female with recessive OSMT1 mutations and neuroimaging findings suggesting a malignant infantile osteopetrosis.

  11. mutations in OSTM1 such as the C-terminal deletion mutant studied herein provoke dysregulation of the canonical Wnt/beta-catenin signaling pathway, providing a molecular basis for severe autosomal recessive osteopetrosis

  12. Mutations in TCIRG1, OSTM1, ClCN7, and TNFRSF11A genes were detected in nine, three, one, and one patientswith infantile malignant osteopetrosis, respectively.

Mouse (Murine) Osteopetrosis Associated Transmembrane Protein 1 (OSTM1) Interaktionspartner

  1. KIF5B is essential for Ostm1 intracellular dispersion.

  2. Truncated OSTM1 significantly inhibited the expression of osteoclast marker genes through the down-regulation of the BLIMP1-NFATc1 axis.

  3. Our in vivo structure-function analysis of ClC-7 reveals that both protein-protein interactions and ion transport must be considered in the pathogenesis of ClC-7-related diseases.

  4. Ostm1 has a primary and autonomous role in neuronal homeostasis

  5. Omi is a recessive mutation in the Ostm1 gene affecting teeth and coat color.

  6. Ostm1 is a bona fide target of miR-140, which is significantly decreased during adipogenic differentiation.

  7. Neuropathologic changes similar to neuronal ceroid lipofuscinosis are found in osteoporosis associated transmembrane protein 1 (Ostml)-deficient mice.

  8. mutation induces severe malignant autosomal recessive osteopetrosis; studies show that Gl protein function is absolutely required for osteoclast and melanocyte maturation and function

  9. both ClC-7 and Ostm1 proteins co-localize in late endosomes and lysosomes of various tissues, as well as in the ruffled border of bone-resorbing osteoclasts

  10. microphthalmia transcription factor regulates Clcn7 and Ostm1 expression in osteoclasts

  11. OSTM1 bone defect reveals an intercellular hematopoietic crosstalk

OSTM1 Antigen-Profil

Beschreibung des Gens

This gene encodes a protein that may be involved in the degradation of G proteins via the ubiquitin-dependent proteasome pathway. The encoded protein binds to members of subfamily A of the regulator of the G-protein signaling (RGS) family through an N-terminal leucine-rich region. This protein also has a central RING finger-like domain and E3 ubiquitin ligase activity. This protein is highly conserved from flies to humans. Defects in this gene may cause the autosomal recessive, infantile malignant form of osteopetrosis.

Genbezeichner und Symbole assoziert mit OSTM1

  • osteopetrosis associated transmembrane protein 1 (OSTM1) Antikörper
  • osteopetrosis associated transmembrane protein 1 (ostm1) Antikörper
  • osteopetrosis associated transmembrane protein 1 (Ostm1) Antikörper
  • 1200002H13Rik Antikörper
  • Gipn Antikörper
  • gl Antikörper
  • HSPC019 Antikörper
  • MGC145644 Antikörper
  • OPTB5 Antikörper
  • OSTM1 Antikörper
  • si:ch73-257c13.3 Antikörper

Bezeichner auf Proteinebene für OSTM1

osteopetrosis-associated transmembrane protein 1 , osteopetrosis associated transmembrane protein 1 , GAIP-interacting protein N terminus , chloride channel 7 beta subunit , grey-lethal osteopetrosis , grey lethal osteopetrosis , GAIP interacting protein N terminus , osteopetrosis associated transmembrane protein 1-like

GENE ID SPEZIES
421773 Gallus gallus
518522 Bos taurus
701341 Macaca mulatta
739203 Pan troglodytes
780037 Xenopus (Silurana) tropicalis
100137453 Papio anubis
100320445 Danio rerio
100328697 Oryctolagus cuniculus
28962 Homo sapiens
14628 Mus musculus
499474 Rattus norvegicus
100049681 Sus scrofa
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