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Osteoclasts are multinucleated cells that resorb bone and are essential for bone homeostasis.
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Data suggest that OSCAR is a collagen receptor (zeige ITGA2 Proteine) that binds to specific collagen motifs and costimulates osteoclastogenesis in DAP12 (zeige TYROBP Proteine)-deficient humans and mice.
PU.1 and MITF (zeige MITF Proteine) transcription factors synergistically activate OSCAR gene expression, which is further enhanced by the TRANCE-induced MKK6 (zeige MAP2K6 Proteine)/p38 (zeige CRK Proteine) signaling cascade.
the FcRgamma (zeige FCER1G Proteine)-mediated signal transduction by OSCAR is involved in osteoclast differentiation
OSCAR but not TREM-2 (zeige TREM2 Proteine) is involved in the positive feedback loop of the immunoreceptor-NFATc1 (zeige NFATC1 Proteine) pathway during osteoclastogenesis
analysis of a positive feedback circuit of TRANCE-induced activation of NFATc1 (zeige NFATC1 Proteine), involving NFATc1 (zeige NFATC1 Proteine)-mediated OSCAR expression and its subsequent activation of NFATc1 (zeige NFATC1 Proteine), necessary for efficient differentiation of osteoclasts
The overexpression of PIAS3 (zeige PIAS3 Proteine) attenuates osteoclast formation and down-regulates the expression of NFATc1 (zeige NFATC1 Proteine) and osteoclast-associated receptor (OSCAR), which are important modulators in osteoclastogenesis.
Results indicate that USFs 1 and 2 serve as modulators in the induction of OSCAR and RANKL (zeige TNFSF11 Proteine)-mediated osteoclastogenesis.
Each domain of OSCAR binds a collagen triple-helical peptide; the primary site is on the C-terminal domain in contrast to GPVI (zeige GP6 Proteine) and LAIR-1 (zeige LAIR1 Proteine).
OSCAR is a receptor for surfactant protein D that activates TNF-alpha release from human CCR2+ inflammatory monocytes.
Data indicate that osteoclast associated receptor (OSCAR) was strongly expressed by the vasculature of active rheumatoid arthritis (RA) patients.
endothelial cell-derived OSCAR was found to be involved in the STAT (zeige STAT1 Proteine) signaling pathway and to affect monocyte adhesion.
OSCAR is expressed in vascular endothelial cells and is regulated by oxLDL involving NFATc1 (zeige NFATC1 Proteine)
hOSCAR thus represents a novel class of molecule expressed by dendritic cells involved in the initiation of the immune response.
ligation of OSCAR promotes dendritic cell survival by an ERK (zeige EPHB2 Proteine)- and PI3K (zeige PIK3CA Proteine)-dependent pathway, linked to expression of the Bcl-2 (zeige BCL2 Proteine) and Bcl-x(L (zeige BCL2L1 Proteine)) antiapoptotic molecules
Human OSCAR mediates the rescue from apoptosis and the cooperation between dendritic cells and antigen-specific T cells that is prevented by CD85j (zeige LILRB1 Proteine) receptor.
Osteoclasts are multinucleated cells that resorb bone and are essential for bone homeostasis. This gene encodes an osteoclast-associated receptor (OSCAR), which is a member of the leukocyte receptor complex (LRC) protein family that plays critical roles in the regulation of both innate and adaptive immune responses. Different from the other LRC members, OSCAR expression is detected specifically in preosteoclasts or mature osteoclasts. OSCAR may be an important bone-specific regulator of osteoclast differentiation. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene.
osteoclast associated, immunoglobulin-like receptor
, osteoclast associated, immunoglobulin-like receptor, isoform 4
, osteoclast-associated immunoglobulin-like receptor
, osteoclast-associated receptor OSCAR
, osteoclast associated receptor OSCAR-S1
, osteoclast associated receptor OSCAR-S2
, poly-Ig receptor 3
, polymeric immunoglobulin receptor 3
, osteoclast associated receptor