anti-Opsin 4 (OPN4) Antikörper

Opsins are members of the guanine nucleotide-binding protein (G protein)-coupled receptor superfamily. Zusätzlich bieten wir Ihnen OPN4 Kits (7) und OPN4 Proteine (4) und viele weitere Produktgruppen zu diesem Protein an.

Alle Antikörper anzeigen Gen GeneID UniProt
OPN4 94233 Q9UHM6
OPN4 30044 Q9QXZ9
OPN4 192223 Q8R456
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Top anti-OPN4 Antikörper auf

Showing 10 out of 24 products:

Katalog Nr. Reaktivität Wirt Konjugat Applikation Bilder Menge Lieferzeit Preis Details
Human Kaninchen Unkonjugiert WB Western blot analysis of Melanopsin expression in HEK293T (A) whole cell lysates. 200 μL 13 bis 14 Tage
Human Kaninchen Unkonjugiert ELISA, WB Western blot analysis of extracts from COLO cells, using OPN4 Antibody. The lane on the right is treated with the synthesized peptide. 100 μg 2 bis 3 Tage
Human Kaninchen Unkonjugiert ELISA, IF, WB Western Blot (WB) analysis of specific lysis using Melanopsin Polyclonal Antibody. 100 μL Verfügbar
Human Kaninchen Unkonjugiert ELISA, ICC, IF, WB Western blot analysis of extracts from COLO cells, using OPN4 antibody.The lane on the left is treated with the antigen-specific peptide. ABIN6276103 staining COLO205 by IF/ICC. The sample were fixed with PFA and permeabilized in 0.1% Triton X-100,then blocked in 10% serum for 45 minutes at 25¡ãC. The primary antibody was diluted at 1/200 and incubated with the sample for 1 hour at 37¡ãC. An  Alexa Fluor 594 conjugated goat anti-rabbit IgG (H+L) Ab, diluted at 1/600, was used as the secondary antibod 100 μL 11 bis 12 Tage
Human Kaninchen Unkonjugiert ELISA, IF, WB 200 μL 12 bis 14 Tage
Human Kaninchen Unkonjugiert IF, WB 0.1 mg 6 bis 8 Tage
Human Kaninchen Unkonjugiert ELISA, WB   100 μg 2 bis 3 Tage
Human Kaninchen Unkonjugiert IF, WB   100 μL 11 bis 14 Tage
Human Kaninchen Unkonjugiert IHC, WB   100 μL 7 bis 8 Tage
Human Kaninchen Unkonjugiert IF, IHC   100 μL 3 bis 4 Tage

Weitere Antikörper gegen OPN4 Interaktionspartner

Human Opsin 4 (OPN4) Interaktionspartner

  1. Seeing the light to change colour: An evolutionary perspective on the role of melanopsin in neuroendocrine circuits regulating light-mediated skin pigmentation.

  2. Valuable insight into the structure-function relationships of human melanopsin, including several key functional residues of the melanopsin protein. The identification of melanopsin variants with significantly altered function may serve to detect individuals with disrupted melanopsin-based light perception, and potentially highlight those at increased risk of sleep disturbance, circadian dysfunction, and visual disorders.

  3. The wide distribution of OPN4 in central areas of the human brain evokes a question whether ambient light has important straight targets in the human brain outside the retinohypothalamic tract.

  4. Trait-like individual differences in the melanopsin phototransduction circuitry contribute to individual differences in sleep timing. Blue light-sensitive young individuals are more prone to delayed sleep.

  5. The light-induced FOS response in melanopsin expressing HEK-293 cells is correlated with melanopsin quantity and dependent on light duration and irradiance.

  6. By broadening the tuning of intrinsically photosensitive retinal ganglion cells, melanopsin tristability produces signal integration.

  7. The response of the human pupil to the separate stimulation of the cones and melanopsin at a range of temporal frequencies under photopic conditions, was measured.

  8. Studied OPN4*Ile394Thr gene polymorphism in association with sleep/wake timing.

  9. The results of this study showed that the post illumination pupil response varied on the basis of OPN4 I394T genotype among individuals with seasonal affective disorder.

  10. Studied the association between melanopsin gene polymorphism and pupillary light reflex under diverse photic conditions, including different intensities and wavelengths.

  11. A comparison of melanopsin with the mechanisms documented for vertebrate (bovine) and invertebrate (squid) visual photoreceptors shows that such a mechanism is not affected by the diversity of the three chromophore cavities.

  12. Significant interaction between the genotype of I394T (TT versus TC+CC) and luminance levels was found in pupil size.

  13. An action spectrum for the calcium response in cells expressing human melanopsin had the predicted form for an opsin : vitamin A1 pigment and peaked at 479 nm. The G-protein selectivity and spectral sensitivity of human melanopsin is similar to that previously described for rodents.

  14. the results indicate that ectopic expression of human OPN4 in orexin neurons enables long-lasting activation of orexin neurons by blue light to control sleep/wakefulness of the mice.

  15. These results suggest that the P10L TT genotype of melanopsin interacts with daylength to predispose individuals to vary in sleep onset and chronotype as a function of daylength.

  16. The relative contribution of melanopsin and visual photoreceptors are assessed by comparing pupillary light reflex responses in a totally visually blind patient with normally sighted individuals.

  17. Melanopsin and mechanisms of non-visual ocular photoreception

  18. The recent advances in the emerging roles of melanopsin and intrinsically photosensitive retinal ganglion cells, are reviewed.

  19. melanopsin acts as a sensory photopigment, coupled to a native ion channel via a G-protein signalling cascade, to drive physiological light detection

  20. an anatomically distinct population of 'giant', melanopsin-expressing ganglion cells in the primate retina that, in addition to being intrinsically photosensitive, are strongly activated by rods and cones

Mouse (Murine) Opsin 4 (OPN4) Interaktionspartner

  1. Melanopsin signaling is repurposed by intrinsically photosensitive retinal ganglion cell subtypes to shape distinct visual behaviors.

  2. we show that OPN2 and OPN4 participate in immediate pigment darkening induced by UVA in murine normal and malignant melanocytes through a conserved common pathway

  3. Data from mouse model reveal a distinct melanopsin contribution to encoding visual images, predicting that, under natural view, melanopsin augments the early visual system's ability to encode patterns over moderate spatial scales.

  4. A subset of M1 and M1d melanopsin ganglion cells are biplexiform with dendrites ramifying both in the inner plexiform layer and either in the inner plexiform layer or the outer plexiform layer. We have found five types of Outer Retinal Dendritess in the OPL categorized by their morphology and the melanopsin ganglion cell subtype from which they originate.

  5. our results highlight how the kinetics of the melanopsin photoresponse differentially regulate distinct light-mediated behaviors.

  6. Melanopsin contributes to irradiance modulation of narrowband oscillations in the retina and dorsal lateral geniculate nucleus.

  7. discovery that amino acid sequence features of melanopsin protein contribute to the functional properties of the intrinsically photosensitive retinal ganglion cells

  8. When compared with wildtype responses, sleep onset in melanopsin (OPN4-/-) mice was significantly advanced under blue light, whereas under violet and green light it was significantly delayed.

  9. Melanopsin overexpression in RGCs enhanced the amplitude and duration of their light response, and silencing them with Kir2.1 significantly suppressed the increased mTOR signaling and axon regeneration that were induced by melanopsin

  10. mice null for melanopsin (Opn4-/-), lost significantly more weight than wild-type controls or mice lacking rod and cone photoreceptors.

  11. These results suggest GRK2 contributes to melanopsin deactivation, but that other mechanisms account for most of modulation of melanopsin activity in ipRGCs.

  12. Using a combination of conventional knockout, chemogenetic, and receptor-silent substitution manipulations, we continued to show that, over higher irradiances, this increase in firing originates with inner-retinal melanopsin photoreception

  13. Opn4 mediates wavelength-specific, light-dependent vascular relaxation.

  14. Data indicate that retinal molecular circadian clock can be entrained by lighting cycles in vitro, but that rods, cones, and melanopsin (Opn4) are not required for this entrainment.

  15. critical phosphorylation sites on the carboxy tail of melanopsin

  16. Melanopsin Is required for normal Sensitivity and expression in alpha retinal ganglion cells.

  17. the role of melanopsin-expressing retinal ganglion cells in the glaucoma-induced depressive behavioral response pattern was investigated

  18. melanopsin is important for initiation and maintenance of light-induced sleep during the dark phase.

  19. The attenuation of the melanopsin-based light response by dopamine is mediated by direct PKA phosphorylation of melanopsin.

  20. when mice are mutated in the gene (Opn4) for the atypical opsin melanopsin, or are dark-reared from late gestation, the hyaloid vessels are persistent at 8 days post-partum and the retinal vasculature overgrows

Turkey Opsin 4 (OPN4) Interaktionspartner

  1. Expressed locally in the premammillary nucleus of the hypothalamus in temperate zone birds, melanopsin is an important regulator of reproductive activity.

Zebrafish Opsin 4 (OPN4) Interaktionspartner

  1. Opn4m2 labeling shows nuclear localization, which did not change in response to light. opn4m1, opn4m2, gr, per1b, and cry1b presented an oscillatory profile of expression in LD condition. In both DD and LD condition, dexamethasone (DEX) treatment shifted the peak expression of per1b and cry1b transcripts

  2. Melanopsin photostimulation triggers the phosphoinositide pathway through activation of a G-Protein, G11.

  3. The opn4a gene is expressed continuously from 1 to 3 dpf in the presumptive preoptic area, as defined by coexpression of the orthopedia homolog (otp) gene.

  4. description of the discovery and functional characterisation of a new melanopsin gene in fish, bird, and amphibian genomes, demonstrating that vertebrates have evolved two quite separate melanopsins

OPN4 Antigen-Profil

Protein Überblick

Opsins are members of the guanine nucleotide-binding protein (G protein)-coupled receptor superfamily. This gene encodes a photoreceptive opsin protein that is expressed within the ganglion and amacrine cell layers of the retina. In mouse, retinal ganglion cell axons expressing this gene projected to the suprachiasmatic nucleus and other brain nuclei involved in circadian photoentrainment. In mouse, this protein is coupled to a transient receptor potential (TRP) ion channel through a G protein signaling pathway and produces a physiologic light response via membrane depolarization and increased intracellular calcium. The protein functions as a sensory photopigment and may also have photoisomerase activity. Experiments with knockout mice indicate that this gene attenuates, but does not abolish, photoentrainment. Alternative splicing results in multiple transcript variants encoding different isoforms.

Genbezeichner und Symbole assoziert mit anti-Opsin 4 (OPN4) Antikörper

  • opsin 4 (OPN4) Antikörper
  • opsin 4 (melanopsin) (Opn4) Antikörper
  • opsin 4 (Opn4) Antikörper
  • melanopsin (LOC100303707) Antikörper
  • melanopsin-B-like L homeolog (LOC100485437.L) Antikörper
  • opsin 4a (melanopsin) (opn4a) Antikörper
  • 1110007J02Rik Antikörper
  • cOpn4L Antikörper
  • Gm533 Antikörper
  • melanopsin Antikörper
  • MOP Antikörper
  • opn4 Antikörper
  • OPN4-2 Antikörper
  • opn4-A Antikörper
  • opn4d Antikörper
  • Xmop Antikörper

Bezeichner auf Proteinebene für anti-Opsin 4 (OPN4) Antikörper

melanopsin , opsin-4 , melanopsin 2 , opsin 4 like , putative Opsin 4 , opsin 4 (melanopsin) , opsin 4 , putative photopigment melanopsin , mammalian-like melanopsin , melanopsin opn4m1 , melanopsin-A , melanopsin-M , opn4m1 , opsin-4-A , opsin-4M

94233 Homo sapiens
30044 Mus musculus
192223 Rattus norvegicus
423609 Gallus gallus
493921 Felis catus
515152 Bos taurus
611027 Canis lupus familiaris
735531 Pan troglodytes
100303707 Meleagris gallopavo
373689 Xenopus laevis
571624 Danio rerio
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