Nudix (Nucleoside Diphosphate Linked Moiety X)-Type Motif 15 Proteine (NUDT15)

Mediates the hydrolysis of some nucleoside diphosphate derivatives. Zusätzlich bieten wir Ihnen NUDT15 Antikörper (37) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
NUDT15 55270 Q9NV35
NUDT15 214254 Q8BG93
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Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 30 bis 35 Tage
Insektenzellen Maus His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 50 Days
HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Anmelden zum Anzeigen 11 Days

NUDT15 Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Human ,
Mouse (Murine)

Weitere Proteine zu Nudix (Nucleoside Diphosphate Linked Moiety X)-Type Motif 15 (NUDT15) Interaktionspartnern

Human Nudix (Nucleoside Diphosphate Linked Moiety X)-Type Motif 15 (NUDT15) Interaktionspartner

  1. Among patients of European ancestry with IBD, variants in NUDT15 were associated with increased risk of thiopurine-induced myelosuppression (TIM).

  2. NUDT15 (and ABCC4) variants are major factors for 6-mercaptopurine intolerability in Japanese childhood acute lymphoblastic leukemia patients.

  3. NUDT15 variant is an optimal predictor for 6-MP intolerance in Chinese pediatric acute lymphoblastic leukemia patients

  4. Retrospective single-center case-control observational study that enrolled a small number of Japanese patients found that NUDT15 R139C homozygosity is a genetic risk of thiopurine (azathioprine)-induced potentially fatal hematological abnormalities.

  5. TPMT and NUDT15 genes are both related to mercaptopurine intolerance in acute lymphoblastic leukaemia patients from Uruguay.

  6. Results show that 6-TGN levels were substantially low in patients with NUDT15 variants who showed highest hematopoietic toxicity. The low ratio of 6-TGN level to 6-mercaptopurine dose in patients with NUDT15 variants seems to be caused by enhanced incorporation of active thiopurine metabolites into DNA.

  7. Mutation rate of NUDT15 in Chinese inflammatory bowel disease patients is higher than that of TPMT. NUDT15 polymorphism is a better predictor for AZA-induced leukopenia than TPMT polymorphism.

  8. Mutations in exon 1 of NUDT15 also affect thiopurine-induced leukopenia in patients with inflammatory bowel disease.

  9. With increasing copy numbers of the risk T allele at NUDT15.

  10. results of this meta-analysis confirm that NUDT15 c.415C>T may be an important predictor of thiopurine-induced leukocytopenia in Asians

  11. NUDT15 c.415C>T, c.36_37insGGAGTC, and c.52G>A variants were risk factors for thiopurine-induced leukopenia. Combined detection of the 3 variants could increase the predictive sensitivity of thiopurine-induced leukopenia and help to distinguish early leukopenia in heterozygote of c.415C>T in Chinese patients with inflammatory bowel disease.

  12. Study replicated previous findings that the NUDT15 p.R139C variant is a potential predictor for AZA-induced leukopenia, extending this finding to patients with various neurological disorders in Korea and identifying its specific association with early leukopenia and severe alopecia. All of the patients who carried a NUDT15 p.R139C homozygous variant exhibited rapid development of severe leukopenia and extensive hair loss.

  13. Thiopurine treatment should not be recommended to patients with NUDT15 homozygous variant genotype due to severe early leukopenia

  14. All patients with both NUDT15 rs116855232 heterozygous variants and ABCC4 rs3765534 variants suffered from severe leukopenia and required 6-mercaptopurine dose reduction to less than 35 mg/m(2)/da

  15. Current review highlights the scientific data on NUDT15 enzyme variant in patients with acute lymphoblastic leukaemia and its relation to 6-mercaptopurine toxicity in various ethnic populations.

  16. 3 novel NUDT15 coding variants (p.R34T, p.K35E, and p.G17_V18del) in 5 children with acute lymphoblastic leukemia enrolled in frontline protocols in Singapore, Taiwan, and at St. Jude Children's Research Hospital.

  17. NUDT15 variant as a predictor for thiopurine-induced toxicity in Indian patients.

  18. NUDT15 gene polymorphism is related to mercaptopurine intolerance in Taiwan Chinese children with acute lymphoblastic leukemia.

  19. our results defined how NUDT15 limits thiopurine efficacy and how genetic ablation via the R139C missense mutation confers sensitivity to thiopurine treatment in patients

  20. NUDT15 polymorphisms are associated with 6-mercaptopurine intolerance in children treated for acute lymphoblastic leukemia.

Mouse (Murine) Nudix (Nucleoside Diphosphate Linked Moiety X)-Type Motif 15 (NUDT15) Interaktionspartner

  1. These results suggest that the MTH2 deficiency might be one of the causative factors for accelerated aging.

  2. MTH2 has a potential to protect the genetic material from the untoward effects of endogenous oxygen radicals; MTH2 could act as an MTH1 redundancy factor [MTH2]

NUDT15 Protein Überblick

Protein Überblick

Mediates the hydrolysis of some nucleoside diphosphate derivatives. Can degrade 8-oxo-dGTP in vitro, suggesting that it may remove an oxidatively damaged form of guanine (7,8-dihydro-8- oxoguanine) from DNA and the nucleotide pool, thereby preventing misincorporation of 8-oxo-dGTP into DNA thus preventing A:T to C:G transversions. Its substrate specificity in vivo however remains unclear. May have a role in DNA synthesis and cell cycle progression through the interaction with PCNA.

Genbezeichner und Symbole assoziert mit NUDT15

  • nudix hydrolase 15 (NUDT15)
  • nudix (nucleoside diphosphate linked moiety X)-type motif 15 (Nudt15)
  • 6530403O17 Protein
  • A730068G11Rik Protein
  • MTH2 Protein
  • RP11-90M2.1 Protein

Bezeichner auf Proteinebene für NUDT15

7,8-dihydro-8-oxoguanine-triphosphatase NUDT15 , 8-oxo-dGTPase NUDT15 , A730068G11Rik , mutT homolog 2 , nucleoside diphosphate-linked moiety X motif 15 , nudix motif 15 , nudix-type motif 15 , probable 7,8-dihydro-8-oxoguanine triphosphatase NUDT15 , probable 8-oxo-dGTP diphosphatase NUDT15 , MutT homolog 2 , mMTH2

55270 Homo sapiens
214254 Mus musculus
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