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Mediates the hydrolysis of some nucleoside diphosphate derivatives. Zusätzlich bieten wir Ihnen NUDT15 Antikörper (34) und viele weitere Produktgruppen zu diesem Protein an.
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Results show that 6-TGN (zeige TG Proteine) levels were substantially low in patients with NUDT15 variants who showed highest hematopoietic toxicity. The low ratio of 6-TGN (zeige TG Proteine) level to 6-mercaptopurine dose in patients with NUDT15 variants seems to be caused by enhanced incorporation of active thiopurine metabolites into DNA.
Mutation rate of NUDT15 in Chinese inflammatory bowel disease patients is higher than that of TPMT (zeige TPMT Proteine). NUDT15 polymorphism is a better predictor for AZA-induced leukopenia than TPMT (zeige TPMT Proteine) polymorphism.
Mutations in exon 1 of NUDT15 also affect thiopurine-induced leukopenia in patients with inflammatory bowel disease.
With increasing copy numbers of the risk T allele at NUDT15.
results of this meta-analysis confirm that NUDT15 c.415C>T may be an important predictor of thiopurine-induced leukocytopenia in Asians
NUDT15 c.415C>T, c.36_37insGGAGTC, and c.52G>A variants were risk factors for thiopurine-induced leukopenia. Combined detection of the 3 variants could increase the predictive sensitivity of thiopurine-induced leukopenia and help to distinguish early leukopenia in heterozygote of c.415C>T in Chinese patients with inflammatory bowel disease.
Study replicated previous findings that the NUDT15 p.R139C variant is a potential predictor for AZA-induced leukopenia, extending this finding to patients with various neurological disorders in Korea and identifying its specific association with early leukopenia and severe alopecia. All of the patients who carried a NUDT15 p.R139C homozygous variant exhibited rapid development of severe leukopenia and extensive hair loss.
Thiopurine treatment should not be recommended to patients with NUDT15 homozygous variant genotype due to severe early leukopenia
All patients with both NUDT15 rs116855232 heterozygous variants and ABCC4 (zeige ABCC4 Proteine) rs3765534 variants suffered from severe leukopenia and required 6-mercaptopurine dose reduction to less than 35 mg/m(2)/da
Current review highlights the scientific data on NUDT15 enzyme variant in patients with acute lymphoblastic leukaemia and its relation to 6-mercaptopurine toxicity in various ethnic populations.
These results suggest that the MTH2 deficiency might be one of the causative factors for accelerated aging.
MTH2 has a potential to protect the genetic material from the untoward effects of endogenous oxygen radicals; MTH2 could act as an MTH1 (zeige NUDT1 Proteine) redundancy factor [MTH2]
Mediates the hydrolysis of some nucleoside diphosphate derivatives. Can degrade 8-oxo-dGTP in vitro, suggesting that it may remove an oxidatively damaged form of guanine (7,8-dihydro-8- oxoguanine) from DNA and the nucleotide pool, thereby preventing misincorporation of 8-oxo-dGTP into DNA thus preventing A:T to C:G transversions. Its substrate specificity in vivo however remains unclear. May have a role in DNA synthesis and cell cycle progression through the interaction with PCNA.
, 8-oxo-dGTPase NUDT15
, mutT homolog 2
, nucleoside diphosphate-linked moiety X motif 15
, nudix motif 15
, nudix-type motif 15
, probable 7,8-dihydro-8-oxoguanine triphosphatase NUDT15
, probable 8-oxo-dGTP diphosphatase NUDT15
, MutT homolog 2