Nuclear Factor (erythroid-Derived 2)-Like 1 Proteine (NFE2L1)

Human Nuclear Factor (erythroid-Derived 2)-Like 1 (NFE2L1) Interaktionspartner

1. Data show that Nrf1 can adopt several topologies within membranes that are determined by its NTD.

2. Fbw7 (zeige FBXW7 Proteine) as a regulator of Nrf1 expression and reveal a novel function of Fbw7 (zeige FBXW7 Proteine) in cellular stress response.

3. results indicate a novel role of Nrf1 in UVB-induced DNA damage repair and suggest Nrf1 as a tumor suppressor in the skin

4. Nrf1 knockout resulted in the increased expression of GCLC (zeige GCLC Proteine) and GCLM (zeige GCLM Proteine) in human bronchial epithelial (HBE1 (zeige HBe1 Proteine)) cells.

5. while Nrf2 (zeige GABPA Proteine) is crucial for MRE/ARE-mediated transcription in response to copper, Nrf1 may activate MT-1 (zeige MT1A Proteine) expression by a mechanism different from that Nrf2 (zeige GABPA Proteine) employs.

6. Nrf1 physically interacts with androgen receptor (zeige AR Proteine) and enhances it's DNA-binding activity, suggesting that the p65 (zeige GORASP1 Proteine)-Nrf1 isoform is a potential androgen receptor (zeige AR Proteine) coactivator.

7. The treatment with E2, Res, or VC significantly increased mRNA and protein expression levels of Nrf1.

8. The results indicate that Nrf1 is a transcriptional activator of Herpud1 (zeige HERPUD1 Proteine) expression during ER stress, and they suggest Nrf1 is a key player in the regulation of the ER stress response in cells.

9. This review outlines Nrf1 structure, function, regulation and its links to insulin (zeige INS Proteine) resistance, diabetes and inflammation.

10. Importantly, Nrf1 activity is positively and/or negatively regulated by distinct doses of proteasome and calpain inhibitors

Mouse (Murine) Nuclear Factor (erythroid-Derived 2)-Like 1 (NFE2L1) Interaktionspartner

1. our investigation shows that the ER membrane protein TCF11/Nrf1 is an essential component of the cellular stress response mechanism. In response to cytotoxic stress, TCF11/Nrf1 is retrotranslocated and transferred to the nucleus where it induces proteasome subunit expression via binding to the ARE region of the relevant promoter.

2. Deficiency of long isoforms of Nfe2l1 in pancreatic beta-cells increased susceptibility to acute arsenite-induced cytotoxicity by promoting arsenic biotransformation and intracellular MMA levels.

3. Nrf1 (zeige NRF1 Proteine) is negatively regulated by its O-GlcNAcylation status that depends on the glucose concentrations

4. Denervation induced proteasomal activation via NFE2L1 nuclear translocation in control mice

5. This stduy identify the bZIP transcription factor Nfe2l1 and demonstrate that it promotes glial fate under direct Sox9 (zeige SOX9 Proteine) regulatory control.

6. The study identifies casein kinase 2 as an NRF1 (zeige NRF1 Proteine)-binding protein and finds that the knockdown of casein kinase 2 enhances the Nrf1 (zeige NRF1 Proteine)-dependent expression of the proteasome subunit genes.

7. Nrf1 (zeige NRF1 Proteine) plays an integral role in the maintenance of proteasome function in hepatocytes and in the prevention of liver steatosis development.

8. findings suggest that nuclear-related factor erythroid 2 transcription factor (Nrf1 (zeige NRF1 Proteine)) may play a role in maintaining genomic integrity, and that Nrf1 (zeige NRF1 Proteine) dysregulation may induce tumorigenesis

9. The transcription factor, TCF11, is at the crossroads of oxidative stress and the ubiquitin proteasome system.

10. Data show that nuclear factor erythroid-derived 2 (zeige NFE2 Proteine)-related factor 1 (Nrf1 (zeige NRF1 Proteine)), but not the related Nrf2 (zeige NFE2L2 Proteine), is necessary for induced proteasome gene transcription in mouse embryonic fibroblasts.