Nuclear Factor (erythroid-Derived 2)-Like 1 Proteine (NFE2L1)

NFE2L1 encodes a protein that is involved in globin gene expression in erythrocytes. Zusätzlich bieten wir Ihnen NFE2L1 Antikörper (66) und NFE2L1 Kits (8) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
NFE2L1 4779 Q14494
NFE2L1 18023 Q61985
Ratte NFE2L1 NFE2L1 360610  
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Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Insektenzellen Maus rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Anmelden zum Anzeigen 60 bis 65 Tage
$7,506.65
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Insektenzellen Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Anmelden zum Anzeigen 60 bis 65 Tage
$10,699.55
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Wheat germ Human GST tag 10 μg Anmelden zum Anzeigen 11 bis 12 Tage
$414.29
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NFE2L1 Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Human ,
,
Mouse (Murine)

Weitere Proteine zu Nuclear Factor (erythroid-Derived 2)-Like 1 (NFE2L1) Interaktionspartnern

Human Nuclear Factor (erythroid-Derived 2)-Like 1 (NFE2L1) Interaktionspartner

  1. Data show that Nrf1 can adopt several topologies within membranes that are determined by its NTD.

  2. Fbw7 as a regulator of Nrf1 expression and reveal a novel function of Fbw7 in cellular stress response.

  3. results indicate a novel role of Nrf1 in UVB-induced DNA damage repair and suggest Nrf1 as a tumor suppressor in the skin

  4. Data indicate both Nrf1a and Nrf1b isoforms transcripts were detected in different mouse and human cell lines, and in various mouse tissues.

  5. Nrf1 knockout resulted in the increased expression of GCLC and GCLM in human bronchial epithelial (HBE1) cells.

  6. while Nrf2 is crucial for MRE/ARE-mediated transcription in response to copper, Nrf1 may activate MT-1 expression by a mechanism different from that Nrf2 employs.

  7. Nrf1 physically interacts with androgen receptor and enhances it's DNA-binding activity, suggesting that the p65-Nrf1 isoform is a potential androgen receptor coactivator.

  8. The treatment with E2, Res, or VC significantly increased mRNA and protein expression levels of Nrf1.

  9. The results indicate that Nrf1 is a transcriptional activator of Herpud1 expression during ER stress, and they suggest Nrf1 is a key player in the regulation of the ER stress response in cells.

  10. This review outlines Nrf1 structure, function, regulation and its links to insulin resistance, diabetes and inflammation.

  11. Importantly, Nrf1 activity is positively and/or negatively regulated by distinct doses of proteasome and calpain inhibitors

  12. Together with molecular expression results, the authors thus suppose requirement of Nrf1alpha (and major derivates) for gene regulatory mechanisms repressing cancer cell process and malignant behaviour.

  13. These results uncover a new regulatory mechanism that USP15 activates Nrf1 against the beta-TrCP inhibition to maintain proteostasis.

  14. Here the authors show that the aspartyl protease DNA-damage inducible 1 homolog 2 (DDI2) is required to cleave and activate Nrf1.

  15. Nrf1 is regulated by O-GlcNAc transferase.

  16. our investigation shows that the ER membrane protein TCF11/Nrf1 is an essential component of the cellular stress response mechanism. In response to cytotoxic stress, TCF11/Nrf1 is retrotranslocated and transferred to the nucleus where it induces proteasome subunit expression via binding to the ARE region of the relevant promoter.

  17. Data uncover an unexpected role for p97 in activation of transcription factor Nrf1 by relocalizing it from the endoplasmic reticulum lumen to the cytosol.

  18. Nrf1 is negatively regulated by its O-GlcNAcylation status that depends on the glucose concentrations

  19. A proteasome inhibitor-stimulated Nrf1 protein-dependent compensatory increase in proteasome subunit gene expression reduces polycomb group protein level

  20. The study identifies casein kinase 2 as an NRF1-binding protein and finds that the knockdown of casein kinase 2 enhances the NRF1-dependent expression of the proteasome subunit genes.

Mouse (Murine) Nuclear Factor (erythroid-Derived 2)-Like 1 (NFE2L1) Interaktionspartner

  1. Mechanistic studies revealed that Nfe2l1 deficiency may disturb the expression of lipolytic genes in adipocytes, leading to adipocyte hypertrophy followed by inflammation, pyroptosis, and insulin resistance.

  2. our investigation shows that the ER membrane protein TCF11/Nrf1 is an essential component of the cellular stress response mechanism. In response to cytotoxic stress, TCF11/Nrf1 is retrotranslocated and transferred to the nucleus where it induces proteasome subunit expression via binding to the ARE region of the relevant promoter.

  3. Deficiency of long isoforms of Nfe2l1 in pancreatic beta-cells increased susceptibility to acute arsenite-induced cytotoxicity by promoting arsenic biotransformation and intracellular MMA levels.

  4. Nrf1 is negatively regulated by its O-GlcNAcylation status that depends on the glucose concentrations

  5. Denervation induced proteasomal activation via NFE2L1 nuclear translocation in control mice

  6. This stduy identify the bZIP transcription factor Nfe2l1 and demonstrate that it promotes glial fate under direct Sox9 regulatory control.

  7. The study identifies casein kinase 2 as an NRF1-binding protein and finds that the knockdown of casein kinase 2 enhances the Nrf1-dependent expression of the proteasome subunit genes.

  8. Nrf1 plays an integral role in the maintenance of proteasome function in hepatocytes and in the prevention of liver steatosis development.

  9. findings suggest that nuclear-related factor erythroid 2 transcription factor (Nrf1) may play a role in maintaining genomic integrity, and that Nrf1 dysregulation may induce tumorigenesis

  10. The transcription factor, TCF11, is at the crossroads of oxidative stress and the ubiquitin proteasome system.

  11. Data show that nuclear factor erythroid-derived 2-related factor 1 (Nrf1), but not the related Nrf2, is necessary for induced proteasome gene transcription in mouse embryonic fibroblasts.

  12. the first in vivo experimental evidence that NFE2L1 produced by osteoblasts is involved in regulating osterix expression, osteoblast differentiation, and bone formation

  13. may promote cell survival by maintaining redox balance and protecting embryonic hepatocytes from TNF-mediated apoptosis during development

  14. the physical interaction between Nrf1 and C/EBPbeta provide a novel mechanism for the transcriptional regulation of DSPP in odontoblasts.

  15. Nrf1 is normally targeted to the endoplasmic reticulum membrane, and endoplasmic reticulum stress may play a role in modulating Nrf1 function as a transcriptional activator

  16. Activation of ARE-driven genes by Nrf1 was negatively controlled by the 155-AA N-terminal domain through its ability to direct Nrf1 to the endoplasmic reticulum.

  17. Arachidonic acid modulated osterix expression by a mechanism involving Nrf1 nuclear translocation and Nrf1 binding to oxidant response elements to activate genes in cell differentiation.

  18. The amino- and carboxyl-terminal regions are required for correct membrane orientation of Nrf1, as deletion of residues 2-10 or 23-30 greatly increase its association with the endoplasmic reticulum and the extent to which it is glycosylated.

NFE2L1 Protein Überblick

Protein Überblick

This gene encodes a protein that is involved in globin gene expression in erythrocytes. Confusion has occurred in bibliographic databases due to the shared symbol of NRF1 for this gene, NFE2L1, and for 'nuclear respiratory factor 1' which has an official symbol of NRF1.

Genbezeichner und Symbole assoziert mit NFE2L1

  • nuclear factor, erythroid 2 like 1 (NFE2L1)
  • nuclear factor, erythroid derived 2,-like 1 (Nfe2l1)
  • nuclear factor, erythroid 2-like 1 (Nfe2l1)
  • nuclear factor, erythroid 2 like 1 (Nfe2l1)
  • nuclear factor, erythroid 2 like 1 S homeolog (nfe2l1.S)
  • nuclear factor, erythroid 2-like 1a (nfe2l1a)
  • AA408798 Protein
  • AW212678 Protein
  • LCR-F1 Protein
  • Lcrf1 Protein
  • nfe2l1 Protein
  • NRF1 Protein
  • TCF-11 Protein
  • TCF11 Protein

Bezeichner auf Proteinebene für NFE2L1

NF-E2-related factor 1 , NFE2-related factor 1 , TCF-11 , locus control region-factor 1 , nuclear factor (erythroid-derived 2)-like 1 , nuclear factor erythroid 2-related factor 1 , nuclear factor, erythroid derived 2, like 1 , transcription factor 11 (basic leucine zipper type) , transcription factor HBZ17 , transcription factor LCR-F1 , nuclear factor erythroid 2-like 1 , nuclear factor, erythroid 2 like 1 S homeolog , nuclear factor, erythroid 2-like 1 , nrf1a , nuclear factor, erythroid derived 2,-like 1 , nuclear factor, erythroid derived 2,-like 1a , nuclear factor-like 1 , nuclear factor-like 1a protein

GENE ID SPEZIES
4779 Homo sapiens
18023 Mus musculus
360610 Rattus norvegicus
417987 Gallus gallus
534582 Bos taurus
100172747 Pongo abelii
100716712 Cavia porcellus
379703 Xenopus laevis
405781 Danio rerio
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