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Expression of interleukin-3 (IL3\; MIM 147740) is restricted to activated T cells, natural killer (NK) cells, and mast cell lines. Zusätzlich bieten wir Ihnen NFIL3 Antikörper (107) und NFIL3 Kits (33) und viele weitere Produktgruppen zu diesem Protein an.
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Human NFIL3 Protein expressed in Wheat germ - ABIN1312476
Ohno, Onishi, Ishida: A novel E4BP4 element drives circadian expression of mPeriod2. in Nucleic acids research 2007
Here we review the regulatory mechanisms of E4BP4 engaging in not only the biological function but also the development of immune-mediated diseases, paving the way for future therapies
glucocorticoid-mediated transactivating pathway may support eosinophil viability in IL-5 (zeige IL5 Proteine)-stimulated cells through synergistic upregulation of NFIL3
E4BP4 and BIM (zeige BCL2L11 Proteine) regulation correlated with that of RCAN1 (zeige RCAN1 Proteine)-1. A putative GRE and four EBPREs were identified within 1500bp upstream from the transcription start site of RCAN1 (zeige RCAN1 Proteine)-1
Results conclude that the transcriptional repressor E4BP4 plays a role in repressing epigenetically regulated SOSTDC1 (zeige SOSTDC1 Proteine) expression in breast cancer cells, which can be reverted by E4BP4 silencing.
NFIL3 plays a neuroprotective role in neurons and constitutes a potential therapeutic target for neurodegeneration.
Data indicate that E4BP4 can inhibit CD40L (zeige CD40LG Proteine) expression through epigenetic modifications in the promoter region of CD40L (zeige CD40LG Proteine).
NFIL3 alters cancer cell behavior and FOXO (zeige FOXO3 Proteine) function by acting on chromatin to restrict the menu of FOXO (zeige FOXO3 Proteine) target genes
The clock-regulated and immune system modulator transcription factor E4BP4/ NFIL3 likely regulates the expression of both appb in zebrafish and APP (zeige APP Proteine) in humans.
G9a (zeige EHMT2 Proteine) mediates E4BP4-dependent suppression of hepatic Fgf21 (zeige FGF21 Proteine) by enhancing histone methylation (H3K9me2) of the Fgf21 (zeige FGF21 Proteine) promoter
Conclude that E4BP4 plays as a survival factor in heart and E4BP4 is essential for proper embryonic heart development.
Study shows that Nfil3 is enriched in the myeloid compartment of adult zebrafish including eosinophils.
conclude that E4BP4/NIFL3 plays as a survival factor in heart and E4BP4 is essential for proper embryonic heart development.
These findings provide mechanistic insight into how the intestinal microbiota regulates body composition and establish NFIL3 as an essential molecular link among the microbiota, the circadian clock, and host metabolism.
E4BP4 acts as a key pro-adipogenic transcription factor by trans-repressing COX2 in glucocorticoid-associated adipocyte differentiation.
NFIL3 functions as an important regulator of glucose homeostasis in the liver by limiting CREB (zeige CREB1 Proteine)-mediated hepatic gluconeogenesis.
We identified PD-1 (zeige PDCD1 Proteine) to be specifically expressed in PLZF (zeige ZBTB16 Proteine)(+) ILCp and revealed that the timing and order of expression of the transcription factors NFIL3, ID2, and TCF-1 (zeige HNF1A Proteine) was critical. Importantly, induction of ILC (zeige CCL27 Proteine) lineage commitment required only transient expression of NFIL3 prior to ID2 and TCF-1 (zeige HNF1A Proteine) expression.
Uterine lumen closure, early embryonic development, and differentiation of antimesometrial decidua were delayed in Nfil3(-/-) implantation sites. Major disturbances to the decidual-trophoblast interface that did not lead to fetal death were attributed to NFIL3 deficiency in trophoblast.
In hepatocytes, E4BP4 interacts with nuclear SREBP-1c (zeige SREBF1 Proteine) to preserve its acetylation, and subsequently protects it from ubiquitination-dependent degradation
study found that approximately one quarter of the submandibular salivary gland (SMG (zeige SNRPG Proteine)) NK cells develop independently of NFIL3; data show that the SMG (zeige SNRPG Proteine) tissue environment shapes a unique repertoire of NK-like cells with distinct phenotypes
New direct Wnt (zeige WNT2 Proteine)/beta-catenin (zeige CTNNB1 Proteine) target gene Nfil3 , which induced epithelial-mesenchymal transition, cell migration and experimental metastasis of Colorectal cancer cells was identified.
removal of NFIL3 in vivo does not recapitulate the regeneration-promoting effects that were previously observed in vitro.
These findings establish that NFIL3 directs the differentiation of a committed innate lymphoid cell precursor.
Expression of interleukin-3 (IL3\; MIM 147740) is restricted to activated T cells, natural killer (NK) cells, and mast cell lines. Transcription initiation depends on the activating capacity of specific protein factors, such as NFIL3, that bind to regulatory regions of the gene, usually upstream of the transcription start site (Zhang et al., 1995
nuclear factor, interleukin 3 regulated
, nuclear factor interleukin-3-regulated protein-like
, E4 promoter-binding protein 4
, interleukin-3 promoter transcriptional activator
, interleukin-3-binding protein 1
, nuclear factor interleukin 3 regulated protein
, nuclear factor interleukin-3-regulated protein
, transcriptional activator NF-IL3A
, E4 promoter binding-protein 4
, E4 binding protein 4-1
, bZIP protein E4BP4
, cE4BP4 protein
, embryo implantation-related NFIL3/E4BP4-like transcription factor