anti-Non-SMC Element 2, MMS21 Homolog (S. Cerevisiae) (NSMCE2) Antikörper

E3 SUMO-protein ligase component of the SMC5-SMC6 complex, a complex involved in repair of DNA double-strand breaks by homologous recombination. Zusätzlich bieten wir Ihnen NSMCE2 Proteine (8) und NSMCE2 Kits (2) und viele weitere Produktgruppen zu diesem Protein an.

Alle Antikörper anzeigen Gen GeneID UniProt
NSMCE2 68501 Q91VT1
NSMCE2 299957 Q4V8A0
NSMCE2 286053 Q96MF7
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Top anti-NSMCE2 Antikörper auf antikoerper-online.de

Showing 10 out of 54 products:

Katalog Nr. Reaktivität Wirt Konjugat Applikation Bilder Menge Anbieter Lieferzeit Preis Details
Rind (Kuh) Kaninchen Unkonjugiert WB WB Suggested Anti-NSMCE2 Antibody Titration: 0.2-1 ug/mlELISA Titer: 1:312500Positive Control: MCF7 cell lysate 100 μL Anmelden zum Anzeigen 2 bis 3 Tage
$289.00
Details
Human Maus Unkonjugiert FACS, IF, WB 100 μL Anmelden zum Anzeigen 11 bis 14 Tage
$522.50
Details
Human Kaninchen Unkonjugiert ELISA, IHC, WB 100 μL Anmelden zum Anzeigen 16 Days
$181.73
Details
Human Kaninchen Unkonjugiert ELISA, WB Western blot analysis NSMCE2 using LOVO whole cell lysates 100 μL Anmelden zum Anzeigen 11 bis 12 Tage
$390.77
Details
Human Kaninchen Unkonjugiert ELISA, IHC, IHC (p), WB Immunohistochemistry-Paraffin: Nse2 Antibody [NBP1-76263] - Rat liver tissue with Nse2 antibody at 5 ug/mL. Western Blot: Nse2 Antibody [NBP1-76263] - 293 cell lysate with Nse2 antibody at (A) 0.5 and (B) 1 ug/mL. 0.1 mg Anmelden zum Anzeigen 8 bis 11 Tage
$488.73
Details
Rind (Kuh) Kaninchen Unkonjugiert IHC, IHC (p), WB Human Testis: Formalin-Fixed, Paraffin-Embedded (FFPE). This image was taken for the unconjugated form of this product. Other forms have not been tested. 50 μg Anmelden zum Anzeigen 11 bis 14 Tage
$727.83
Details
Human Maus Unkonjugiert IF, WB Western Blot analysis of NSMCE2 expression in transfected 293T cell line by NSMCE2 MaxPab polyclonal antibody.Lane 1: C8orf36 transfected lysate(27.17 KDa).Lane 2: Non-transfected lysate. Immunofluorescence of purified MaxPab antibody to NSMCE2 on HeLa cell. [antibody concentration 10 ug/ml] 50 μL Anmelden zum Anzeigen 11 bis 12 Tage
$440.00
Details
Human Kaninchen Unkonjugiert EIA, WB   0.1 mg Anmelden zum Anzeigen 8 bis 11 Tage
$474.10
Details
Human Kaninchen Unkonjugiert ELISA, IHC (p), WB 200 μL Anmelden zum Anzeigen 12 bis 14 Tage
$438.90
Details
Human Kaninchen Unkonjugiert ELISA, WB   100 μg Anmelden zum Anzeigen 15 bis 19 Tage
$527.03
Details

Am meisten referenzierte anti-NSMCE2 Antikörper

  1. Human Polyclonal NSMCE2 Primary Antibody für IF, WB - ABIN531598 : Chung, Leonhardt, Rippe: De novo assembly of a PML nuclear subcompartment occurs through multiple pathways and induces telomere elongation. in Journal of cell science 2011 (PubMed)
    Show all 2 Pubmed References

  2. Human Polyclonal NSMCE2 Primary Antibody für ELISA, IHC - ABIN4340745 : Verver, Zheng, Speijer, Hoebe, Dekker, Repping, Stap, Hamer: Non-SMC Element 2 (NSMCE2) of the SMC5/6 Complex Helps to Resolve Topological Stress. in International journal of molecular sciences 2016 (PubMed)

Weitere Antikörper gegen NSMCE2 Interaktionspartner

Human Non-SMC Element 2, MMS21 Homolog (S. Cerevisiae) (NSMCE2) Interaktionspartner

  1. Absence of NSMCE2 affects survival upon topoisomerase II inhibitor etoposide-induced DNA double-strand breaks double-strand breaks.

  2. our study identified novel PVT1-NSMCE2 and CCDC26-NSMCE2 fusion genes that may play functional roles in leukemia.

  3. support a role for NSMCE2 in recovery from DNA damage and raise the possibility that loss of its function produces dwarfism through reduced tolerance of replicative stress

  4. show that the Smc5/6 subunit Mms21 sumoylates multiple lysines of the cohesin subunit Scc1

  5. Studies indicate that Nse1 may function as a ubiquitin ligase, and is targeted to chromatin through its interaction with the Smc5/6 complex.

  6. the human SMC5/6 complex and the SUMO ligase activity of hMMS21 are required for the prevention of DNA damage-induced apoptosis by facilitating DNA repair in human cells

  7. MMS21 dependent sumoylation is integral and important to the cohesion mechanism and mitotic progression and that this function appears to be independent of SMC6.

NSMCE2 Antigen-Profil

Protein Überblick

E3 SUMO-protein ligase component of the SMC5-SMC6 complex, a complex involved in repair of DNA double-strand breaks by homologous recombination. Is not be required for the stability of the complex.The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination and mediates sumoylation of shelterin complex (telosome) components. Acts as a E3 ligase mediating SUMO attachment to various proteins such as SMC6L1 and TRAX, the shelterin complex subunits TERF1, TERF2, TINF2 and TERF2IP, and maybe the cohesin components RAD21 and STAG2. Required for recruitment of telomeres to PML nuclear bodies. SUMO protein-ligase activity is required for the prevention of DNA damage-induced apoptosis by facilitating DNA repair. Required for sister chromatid cohesion during prometaphase and mitotic progression (By similarity).

Genbezeichner und Symbole assoziert mit NSMCE2

  • NSE2/MMS21 homolog, SMC5-SMC6 complex SUMO ligase (Nsmce2) Antikörper
  • NSE2/MMS21 homolog, SMC5-SMC6 complex SUMO ligase (NSMCE2) Antikörper
  • NSE2/MMS21 homolog, SMC5-SMC6 complex SUMO ligase L homeolog (nsmce2.L) Antikörper
  • Smc5-6 complex non-SMC subunit 2 (nse2) Antikörper
  • 1110014D18Rik Antikörper
  • AI661537 Antikörper
  • C8orf36 Antikörper
  • MMS21 Antikörper
  • Non-SMC element 2 Antikörper
  • NSE2 Antikörper
  • RGD1305156 Antikörper
  • ZMIZ7 Antikörper

Bezeichner auf Proteinebene für NSMCE2

E3 SUMO-protein ligase NSE2 , MMS21 homolog , non-structural maintenance of chromosomes element 2 homolog , non-SMC element 2 homolog , hMMS21 , methyl methanesulfonate sensitivity gene 21 , zinc finger, MIZ-type containing 7 , non-SMC element 2 homolog (MMS21, S. cerevisiae) , Non-structural maintenance of chromosomes element 2

GENE ID SPEZIES
68501 Mus musculus
299957 Rattus norvegicus
286053 Homo sapiens
519974 Bos taurus
379272 Xenopus laevis
100724833 Cavia porcellus
2542312 Schizosaccharomyces pombe 972h-
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