Non-POU Domain Containing, Octamer-Binding Proteine (NONO)

NONO encodes an RNA-binding protein which plays various roles in the nucleus, including transcriptional regulation and RNA splicing. Zusätzlich bieten wir Ihnen NONO Antikörper (122) und NONO Kits (6) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
NONO 4841 Q15233
NONO 317259 Q5FVM4
NONO 53610 Q99K48
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Top NONO Proteine auf

Showing 7 out of 9 products:

Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Escherichia coli (E. coli) Maus His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 30 bis 35 Tage
Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 30 bis 35 Tage
HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Anmelden zum Anzeigen 11 Days
Wheat germ Human GST tag 10 μg Anmelden zum Anzeigen 11 bis 12 Tage
Hefe Ratte His tag   1 mg Anmelden zum Anzeigen 60 bis 71 Tage
Escherichia coli (E. coli) Human Unkonjugiert   5 applications Anmelden zum Anzeigen 1 bis 2 Tage
Escherichia coli (E. coli) Human Unkonjugiert   100 μg Anmelden zum Anzeigen 11 bis 18 Tage

NONO Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Human , ,
, ,
Rat (Rattus) ,

Mouse (Murine)

Weitere Proteine zu Non-POU Domain Containing, Octamer-Binding (NONO) Interaktionspartnern

Human Non-POU Domain Containing, Octamer-Binding (NONO) Interaktionspartner

  1. lncRNA pancEts-1 exhibits oncogenic properties that drive the progression of gastric cancer via regulating the NONO/ERG/Ets-1 axis.

  2. We showed that NONO interacts with the nuclear FBW7a isoform and its ubiquitination is regulated following modulation of the GSK3b kinase. Mutation of T428A/T432A within the degron impaired polyubiquitination upon FBW7a and GSK3b overexpression

  3. Results show that NONO is upregulated in human esophageal squamous cell carcinoma (ESCC) tissue samples. Other findings suggest that NONO plays a potent role in multiple biological aspects of ESCC through activation of the Akt and Erk1/2 signaling pathways.

  4. we observed, for the first time, that the expression of p54 was markedly increased in the synovial tissues of rheumatoid arthritis patients.

  5. Findings reveal a new mechanism whereby HUR protects NONO from mir320-mediated degradation upon UVC exposure and identify a new component within the complex network of players underlying the DNA damage response adding mir320a to the list of p53-regulated targets upon genotoxic stress.

  6. GAPLINC has a role in promoting colorectal cancer invasion via binding to PSF/NONO and partly by stimulating the expression of SNAI2

  7. Here, it is reported that l-proline stabilizes purified NONO homodimers, enabling good-quality solution small-angle X-ray structure determination and crystallization. NONO crystallized in the apparent space group P21 with a unique axis (b) of 408.9 A and with evidence of twinning, as indicated by the cumulative intensity distribution L statistic, suggesting the possibility of space group P1.

  8. Mechanistic dissection reveals that NEAT1 broadly interacts with the NONO-PSF heterodimer as well as many other RNA-binding proteins and that multiple RNA segments in NEAT1, including a 'pseudo pri-miRNA' near its 3' end, help attract the Drosha-DGCR8 Microprocessor.

  9. The SFPQ*NONO complex contains an RNA binding domain, and prior work has demonstrated diverse roles in RNA metabolism. It is thus plausible that the additional repair function of NONO, revealed in cell-based assays, could involve RNA interaction.

  10. NEAT1-associated paraspeckle proteins P54nrb and PSF have been reported as positive regulators of c-Myc translation through interaction with c-Myc IRES

  11. Exome analysis identified a novel de novo splice-site variant c.1171+1G>T in exon 11 of NONO gene in a patient with intellectual disability and non-compaction cardiomyopathy.

  12. Case Report: melanotic PEComa of the sinonasal mucosa with NONO-TFE3 fusion.

  13. High expression of P54 is associated with breast cancer.

  14. The present study indicates that p54nrb is a powerful molecule involved in the regulation of cell motility and promotes the migration and invasion of THP1 cells, and it is more likely to be involved in the release of inflammatory mediators and the motility of inflammatory cells.

  15. p54(nrb) is a novel regulator of SREBP-1a in the nucleus, and the data suggest that p54(nrb) regulation of SREBP-1a supports the increased cellular demand of lipids for breast cancer growth.

  16. Data uncover a new role for NONO in mediating the cellular response to UV-induced DNA damage.

  17. p54nrb and hnRNPM knockdown silences the FGF1 promoter-dependent accumulation of mRNA during myoblast differentiation.

  18. Subnuclear re-localization of SOX10 and p54NRB correlates with a unique neurological phenotype associated with SOX10 missense mutations

  19. These data suggest that NonO negatively regulates HIV-1 infection in CD4(+) T cells, highlighting the importance of host proteins associated with HIV-1 preintegration complexes in regulating viral replication.

  20. Mutations in NONO led to defects at inhibitory synapses in intellectual disability syndrome.

Mouse (Murine) Non-POU Domain Containing, Octamer-Binding (NONO) Interaktionspartner

  1. Nono overexpression increased the expression of pro-inflammatory cytokines leading to increased atherosclerotic plaque formation.

  2. These findings argue that Nono collaborates with Erk signaling to regulate the integrity of bivalent domains and Mouse embryonic stem cell pluripotency.

  3. NONO deficiency significantly compromises the response to ionizing radiation-induced DNA damage in the testes, consistent with cell type-specific loss of DSB repair capacity. The results provide evidence that this RNA binding protein significantly contributes to the DNA damage response in vivo.

  4. Data indicate involvement of non-POU domain-containing octamer-binding protein (NONO)/paraspeckle protein component 1 (PSPC1)-aldehyde dehydrogenase 1 (NONO/PSPC1-ALDH1A1) in the modulation of Sertoli cells (SCs) response to mono-(2-ethylhexyl) phthalate (MEHP) challenge.

  5. This study provides an improved understanding of the molecular basis (structure and dynamics) that governs the binding of the p54(nrb)/NonO RRM1 to one of its target RNAs.

  6. mechanisms have therapeutic implications for reducing beta-cell proliferation in insulinomas by inhibiting phospho-HLXB9 or its interaction with Nono and modulating the expression of its direct (Cblb) or indirect (c-Met) targets

  7. Cytoplasmic granule containing HERMES, NonO, PSF, and G3BP1 is a neuronal RNA-protein granule that is transported in neurites during retinal differentiation.

  8. Quantitative proteomics reveals dynamic interaction of JNK with RNA transport granule proteins Sfpq and Nono during neuronal differentiation

  9. We analyzed the expression of sperm-specific Akap3 and the potential regulatory factors of its protein synthesis during mouse spermiogenesis.

  10. NONO genetic insufficiency led to upregulation of PSPC1, which replaced NONO in a stable complex with SFPQ.

  11. Dsta indicate that NONO bound to p16-Ink4A cell cycle checkpoint gene and potentiated its circadian activation in a PER protein-dependent fashion.

  12. Basal and cyclic AMP-induced Rbp4 transcription is regulated by a multiprotein complex that is similar to ones that modulate expression of genes of steroid hormone biosynthesis.

  13. p54nrb is a target of the peptidylprolyl isomerase Pin1, suggesting that it may be regulated by phosphorylation-dependent conformational changes as many other nuclear proteins upon entry into mitosis

  14. identified two proteins, NONO and WDR5, that can associate with the mammalian PER1 protein; data suggest that NONO probably operates antagonistically to PER proteins in mammalian cells, and that it is essential to normal circadian rhythmicity

  15. PSPC1, NONO, and SFPQ form complexes with each other in Sertoli cells and may regulate androgen receptor-mediated transcriptional activity

  16. Non-POU-domain-containing, octamer-binding protein NonO overexpression downregulates COX-2 promoter activity in pancreatic-beta RINm5F cells.

  17. p54nrb plays an important role in the regulation of Sox9 function and the formation of paraspeckle bodies during chondrogenesis

NONO Protein Überblick

Protein Überblick

This gene encodes an RNA-binding protein which plays various roles in the nucleus, including transcriptional regulation and RNA splicing. A rearrangement between this gene and the transcription factor E3 gene has been observed in papillary renal cell carcinoma. Alternatively spliced transcript variants have been described. Pseudogenes exist on Chromosomes 2 and 16.

Genbezeichner und Symbole assoziert mit NONO

  • non-POU domain containing octamer binding (NONO)
  • non-POU domain containing, octamer-binding (NONO)
  • non-POU domain containing, octamer-binding (Nono)
  • non-POU domain containing, octamer binding L homeolog (nono.L)
  • non-POU-domain-containing, octamer binding protein (Nono)
  • AA407051 Protein
  • AV149256 Protein
  • nmt55 Protein
  • nonA Protein
  • nrb54 Protein
  • P54 Protein
  • p54nrb Protein
  • xp54nrb Protein

Bezeichner auf Proteinebene für NONO

54 kDa nuclear RNA- and DNA-binding protein , 55 kDa nuclear protein , DNA-binding p52/p100 complex, 52 kDa subunit , non-POU domain-containing octamer (ATGCAAAT) binding protein , non-POU domain-containing octamer-binding protein , p54(nrb) , non-POU-domain-containing, octamer-binding protein , 54 kD nuclear RNA-binding protein

4841 Homo sapiens
428701 Gallus gallus
612773 Canis lupus familiaris
615175 Bos taurus
317259 Rattus norvegicus
380427 Xenopus laevis
53610 Mus musculus
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