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NONO encodes an RNA-binding protein which plays various roles in the nucleus, including transcriptional regulation and RNA splicing. Zusätzlich bieten wir Ihnen NONO Antikörper (133) und NONO Kits (6) und viele weitere Produktgruppen zu diesem Protein an.
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Findings reveal a new mechanism whereby HUR (zeige ELAVL1 Proteine) protects NONO from mir320-mediated degradation upon UVC exposure and identify a new component within the complex network of players underlying the DNA damage response adding mir320a to the list of p53 (zeige TP53 Proteine)-regulated targets upon genotoxic stress.
GAPLINC has a role in promoting colorectal cancer invasion via binding to PSF/NONO and partly by stimulating the expression of SNAI2
Here, it is reported that l-proline stabilizes purified NONO homodimers, enabling good-quality solution small-angle X-ray structure determination and crystallization. NONO crystallized in the apparent space group P21 (zeige CDKN1A Proteine) with a unique axis (b) of 408.9 A and with evidence of twinning, as indicated by the cumulative intensity distribution L statistic, suggesting the possibility of space group P1.
Mechanistic dissection reveals that NEAT1 broadly interacts with the NONO-PSF (zeige IGFBP7 Proteine) heterodimer as well as many other RNA-binding proteins and that multiple RNA segments in NEAT1, including a 'pseudo pri-miRNA' near its 3' end, help attract the Drosha (zeige DROSHA Proteine)-DGCR8 (zeige DGCR8 Proteine) Microprocessor.
The SFPQ*NONO complex contains an RNA binding domain, and prior work has demonstrated diverse roles in RNA metabolism. It is thus plausible that the additional repair function of NONO, revealed in cell-based assays, could involve RNA interaction.
NEAT1-associated paraspeckle proteins P54nrb and PSF (zeige IGFBP7 Proteine) have been reported as positive regulators of c-Myc (zeige MYC Proteine) translation through interaction with c-Myc (zeige MYC Proteine) IRES
Exome analysis identified a novel de novo splice-site variant c.1171+1G>T in exon 11 of NONO gene in a patient with intellectual disability and non-compaction cardiomyopathy.
Case Report: melanotic PEComa of the sinonasal mucosa with NONO-TFE3 (zeige TFE3 Proteine) fusion.
High expression of P54 (zeige DDX6 Proteine) is associated with breast cancer.
The present study indicates that p54nrb is a powerful molecule involved in the regulation of cell motility and promotes the migration and invasion of THP1 cells, and it is more likely to be involved in the release of inflammatory mediators and the motility of inflammatory cells.
These findings argue that Nono collaborates with Erk (zeige EPHB2 Proteine) signaling to regulate the integrity of bivalent domains and Mouse embryonic stem cell pluripotency.
NONO deficiency significantly compromises the response to ionizing radiation-induced DNA damage in the testes, consistent with cell type-specific loss of DSB repair capacity. The results provide evidence that this RNA binding protein significantly contributes to the DNA damage response in vivo.
Data indicate involvement of non-POU domain-containing octamer-binding protein (NONO)/paraspeckle protein component 1 (PSPC1 (zeige PSPC1 Proteine))-aldehyde dehydrogenase 1 (NONO/PSPC1 (zeige PSPC1 Proteine)-ALDH1A1 (zeige ALDH1A1 Proteine)) in the modulation of Sertoli cells (SCs (zeige TWIST1 Proteine)) response to mono-(2-ethylhexyl) phthalate (MEHP) challenge.
This study provides an improved understanding of the molecular basis (structure and dynamics) that governs the binding of the p54(nrb)/NonO RRM1 (zeige RRM1 Proteine) to one of its target RNAs.
mechanisms have therapeutic implications for reducing beta-cell proliferation in insulinomas by inhibiting phospho-HLXB9 or its interaction with Nono and modulating the expression of its direct (Cblb) or indirect (c-Met) targets
Cytoplasmic granule containing HERMES (zeige CD44 Proteine), NonO, PSF (zeige IL-3 Proteine), and G3BP1 (zeige G3BP1 Proteine) is a neuronal RNA-protein granule that is transported in neurites during retinal differentiation.
Quantitative proteomics reveals dynamic interaction of JNK (zeige MAPK8 Proteine) with RNA transport granule proteins Sfpq and Nono during neuronal differentiation
We analyzed the expression of sperm-specific Akap3 and the potential regulatory factors of its protein synthesis during mouse spermiogenesis.
NONO genetic insufficiency led to upregulation of PSPC1, which replaced NONO in a stable complex with SFPQ.
Dsta indicate that NONO bound to p16-Ink4A cell cycle checkpoint gene and potentiated its circadian activation in a PER protein-dependent fashion.
This gene encodes an RNA-binding protein which plays various roles in the nucleus, including transcriptional regulation and RNA splicing. A rearrangement between this gene and the transcription factor E3 gene has been observed in papillary renal cell carcinoma. Alternatively spliced transcript variants have been described. Pseudogenes exist on Chromosomes 2 and 16.
54 kDa nuclear RNA- and DNA-binding protein
, 55 kDa nuclear protein
, DNA-binding p52/p100 complex, 52 kDa subunit
, non-POU domain-containing octamer (ATGCAAAT) binding protein
, non-POU domain-containing octamer-binding protein
, non-POU-domain-containing, octamer-binding protein
, 54 kD nuclear RNA-binding protein