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Suppresses Src-dependent tyrosine phosphorylation and activation of PDPK1 and its downstream signaling. Zusätzlich bieten wir Ihnen NPRL2 Antikörper (89) und und viele weitere Produktgruppen zu diesem Protein an.
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NPRL2 overexpression enhances sensitivity to CPT (zeige CHPT1 Proteine)-11 treatment in colon cancer cells.
We found no correlation between the DLEC1, TUSC4 and MLH1 (zeige MLH1 Proteine) gene expression and NSCLC patient characteristics (gender, age and smoking) or cancer histopathology. No significant differences in the gene expression among NSCLC subtypes indicate the weakness of DLEC1, TUSC4 and MLH1 (zeige MLH1 Proteine) expression analysis as potential differentiating markers of NSCLC subtypes in the Polish population.
This study demonstrated that NPRL2 mutation in familial focal epilepsies and focal cortical dysplasia.
Data confirmed NPRL2 was downregulated in gliomas. More importantly, NPRL2 was able to inhibit cell proliferation in vitro and repress tumorigenicity in vivo, suggesting its role as a tumor suppressor.
The positive regulation of mTORC1 activity by NPRL2 is mediated through NPRL2 interaction with Raptor (zeige RPTOR Proteine).
NPRL2 mutations are significant cause of focal epilepsy.
NPRL2 acts as a functional tumor suppressor in colorectal cancer cell lines.
NPRL2 enhances sensitivity to oxaliplatin in colon cancer cells.
Decreased expression of NPRL2 is associated with renal cancer.
NPRL2 mRNA blood levels could be a potentially useful marker for the detection of early stage adenomas and colorectal cancers.
Suppresses Src-dependent tyrosine phosphorylation and activation of PDPK1 and its downstream signaling. Down-regulates PDPK1 kinase activity by interfering with tyrosine phosphorylation at the Tyr-9 Tyr-373 and Tyr-376 residues. May act as a tumor suppressor. Suppresses cell growth and enhanced sensitivity to various anticancer drugs.
, gene 21 protein
, nitrogen permase homolog
, nitrogen permease regulator 2-like protein
, tumor suppressor candidate 4
, G21 protein
, homologous to yeast nitrogen permease (candidate tumor suppressor)