Nitrogen Permease Regulator-Like 2 (S. Cerevisiae) Proteine (NPRL2)

Suppresses Src-dependent tyrosine phosphorylation and activation of PDPK1 and its downstream signaling. Zusätzlich bieten wir Ihnen NPRL2 Antikörper (89) und und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
NPRL2 56032 Q9WUE4
NPRL2 10641 Q8WTW4
Ratte NPRL2 NPRL2 363138  
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Showing 4 out of 4 products:

Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Insektenzellen Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 50 Days
$6,869.04
Details
Insektenzellen Maus His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 50 Days
$6,869.04
Details
Wheat germ Human GST tag 10 μg Anmelden zum Anzeigen 11 bis 12 Tage
$414.29
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Hefe Rind (Kuh) His tag   1 mg Anmelden zum Anzeigen 60 bis 71 Tage
$3,045.17
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NPRL2 Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Mouse (Murine)

Human ,
,

Weitere Proteine zu Nitrogen Permease Regulator-Like 2 (S. Cerevisiae) (NPRL2) Interaktionspartnern

Human Nitrogen Permease Regulator-Like 2 (S. Cerevisiae) (NPRL2) Interaktionspartner

  1. NPRL2 overexpression enhances sensitivity to CPT (zeige CHPT1 Proteine)-11 treatment in colon cancer cells.

  2. We found no correlation between the DLEC1, TUSC4 and MLH1 (zeige MLH1 Proteine) gene expression and NSCLC patient characteristics (gender, age and smoking) or cancer histopathology. No significant differences in the gene expression among NSCLC subtypes indicate the weakness of DLEC1, TUSC4 and MLH1 (zeige MLH1 Proteine) expression analysis as potential differentiating markers of NSCLC subtypes in the Polish population.

  3. This study demonstrated that NPRL2 mutation in familial focal epilepsies and focal cortical dysplasia.

  4. Data confirmed NPRL2 was downregulated in gliomas. More importantly, NPRL2 was able to inhibit cell proliferation in vitro and repress tumorigenicity in vivo, suggesting its role as a tumor suppressor.

  5. The positive regulation of mTORC1 activity by NPRL2 is mediated through NPRL2 interaction with Raptor (zeige RPTOR Proteine).

  6. NPRL2 mutations are significant cause of focal epilepsy.

  7. NPRL2 acts as a functional tumor suppressor in colorectal cancer cell lines.

  8. NPRL2 enhances sensitivity to oxaliplatin in colon cancer cells.

  9. Decreased expression of NPRL2 is associated with renal cancer.

  10. NPRL2 mRNA blood levels could be a potentially useful marker for the detection of early stage adenomas and colorectal cancers.

NPRL2 Protein Überblick

Protein Überblick

Suppresses Src-dependent tyrosine phosphorylation and activation of PDPK1 and its downstream signaling. Down-regulates PDPK1 kinase activity by interfering with tyrosine phosphorylation at the Tyr-9 Tyr-373 and Tyr-376 residues. May act as a tumor suppressor. Suppresses cell growth and enhanced sensitivity to various anticancer drugs.

Genbezeichner und Symbole assoziert mit NPRL2

  • nitrogen permease regulator-like 2 (Nprl2)
  • NPR2 like, GATOR1 complex subunit S homeolog (nprl2.S)
  • NPR2 like, GATOR1 complex subunit (NPRL2)
  • NPR2-like, GATOR1 complex subunit (Nprl2)
  • NPR2 like, GATOR1 complex subunit (nprl2)
  • 2810446G01Rik Protein
  • G21 Protein
  • im:6900399 Protein
  • NPR2 Protein
  • npr2l Protein
  • TUSC4 Protein
  • zgc:153630 Protein

Bezeichner auf Proteinebene für NPRL2

NPR2-like protein , gene 21 protein , nitrogen permase homolog , nitrogen permease regulator 2-like protein , tumor suppressor candidate 4 , 2810446G01Rik , G21 protein , homologous to yeast nitrogen permease (candidate tumor suppressor)

GENE ID SPEZIES
56032 Mus musculus
379794 Xenopus laevis
10641 Homo sapiens
476614 Canis lupus familiaris
508487 Bos taurus
363138 Rattus norvegicus
559391 Danio rerio
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