Nitrogen Permease Regulator-Like 2 (S. Cerevisiae) Proteine (NPRL2)

Suppresses Src-dependent tyrosine phosphorylation and activation of PDPK1 and its downstream signaling. Zusätzlich bieten wir Ihnen NPRL2 Antikörper (91) und und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
NPRL2 56032 Q9WUE4
NPRL2 10641 Q8WTW4
Ratte NPRL2 NPRL2 363138  
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Showing 4 out of 4 products:

Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Insektenzellen Maus His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 50 Days
Insektenzellen Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 50 Days
Wheat germ Human GST tag 10 μg Anmelden zum Anzeigen 11 bis 12 Tage
Hefe Rind (Kuh) His tag   1 mg Anmelden zum Anzeigen 60 bis 71 Tage

NPRL2 Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Mouse (Murine)

Human ,

Weitere Proteine zu Nitrogen Permease Regulator-Like 2 (S. Cerevisiae) (NPRL2) Interaktionspartnern

Human Nitrogen Permease Regulator-Like 2 (S. Cerevisiae) (NPRL2) Interaktionspartner

  1. Arg-78 of Nprl2 catalyzes GATOR1-stimulated GTP hydrolysis by the Rag GTPases.

  2. overall, 63 distinct variants were identified: 53 in DEPDC5, three in NPRL2 and seven in NPRL3 . Among these, 46 were novel (including 39 single nucleotide variants and seven CNVs) and 16 were newly defined as recurrent variants; 34 were loss-of-function (LoF) variants (nonsense, splice-site, frameshift indels and CNVs).

  3. The expression level of NPRL2 was significantly up-regulated in prostate cancer and its high expression was correlated with poor prognosis.

  4. The high levels of NPRL2 expression in castrate-resistant prostate cancer promote resistance to Everolimus by enhancing autophagy.

  5. NPRL2 overexpression enhances sensitivity to CPT-11 treatment in colon cancer cells.

  6. We found no correlation between the DLEC1, TUSC4 and MLH1 gene expression and NSCLC patient characteristics (gender, age and smoking) or cancer histopathology. No significant differences in the gene expression among NSCLC subtypes indicate the weakness of DLEC1, TUSC4 and MLH1 expression analysis as potential differentiating markers of NSCLC subtypes in the Polish population.

  7. This study demonstrated that NPRL2 mutation in familial focal epilepsies and focal cortical dysplasia.

  8. Data confirmed NPRL2 was downregulated in gliomas. More importantly, NPRL2 was able to inhibit cell proliferation in vitro and repress tumorigenicity in vivo, suggesting its role as a tumor suppressor.

  9. The positive regulation of mTORC1 activity by NPRL2 is mediated through NPRL2 interaction with Raptor.

  10. NPRL2 mutations are significant cause of focal epilepsy.

  11. NPRL2 acts as a functional tumor suppressor in colorectal cancer cell lines.

  12. NPRL2 enhances sensitivity to oxaliplatin in colon cancer cells.

  13. Decreased expression of NPRL2 is associated with renal cancer.

  14. NPRL2 mRNA blood levels could be a potentially useful marker for the detection of early stage adenomas and colorectal cancers.

  15. Results provide a set of genetic and biologic proofs that TUSC4 functions as a bona fide tumor suppressor by regulating the protein stability and function of BRCA1 in breast cancer.

  16. NPRL2 expression is negatively related with the survival of osteosarcoma patients, indicating its value as a prognosis factor of osteosarcoma.

  17. Lower NPRL2 expression was observed significantly more frequently in poorly differentiated tumor samples than in highly or moderately differentiated colon tumors.

  18. tumor suppressor genes RBSP3/CTDSPL, NPRL2/G21 and RASSF1A are downregulated in primary non-small cell lung cancer

  19. Data indicate that Npr2, a homolog of human NPRL2, is a phosphorylation-dependent target of the SCF(Grr1) E3 ubiquitin ligase that plays a role in cell growth on some nitrogen sources.

  20. NPRL2 is a multiple tumor suppressor gene.

NPRL2 Protein Überblick

Protein Überblick

Suppresses Src-dependent tyrosine phosphorylation and activation of PDPK1 and its downstream signaling. Down-regulates PDPK1 kinase activity by interfering with tyrosine phosphorylation at the Tyr-9 Tyr-373 and Tyr-376 residues. May act as a tumor suppressor. Suppresses cell growth and enhanced sensitivity to various anticancer drugs.

Genbezeichner und Symbole assoziert mit NPRL2

  • nitrogen permease regulator-like 2 (Nprl2)
  • NPR2 like, GATOR1 complex subunit S homeolog (nprl2.S)
  • NPR2 like, GATOR1 complex subunit (NPRL2)
  • NPR2-like, GATOR1 complex subunit (Nprl2)
  • NPR2 like, GATOR1 complex subunit (nprl2)
  • 2810446G01Rik Protein
  • G21 Protein
  • im:6900399 Protein
  • NPR2 Protein
  • npr2l Protein
  • TUSC4 Protein
  • zgc:153630 Protein

Bezeichner auf Proteinebene für NPRL2

NPR2-like protein , gene 21 protein , nitrogen permase homolog , nitrogen permease regulator 2-like protein , tumor suppressor candidate 4 , 2810446G01Rik , G21 protein , homologous to yeast nitrogen permease (candidate tumor suppressor)

56032 Mus musculus
379794 Xenopus laevis
10641 Homo sapiens
476614 Canis lupus familiaris
508487 Bos taurus
363138 Rattus norvegicus
559391 Danio rerio
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