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NID1 encodes a member of the nidogen family of basement membrane glycoproteins.
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Analysis of nidogen-1 and laminin-gamma1 interaction reveals multiple binding modes.
These studies provide strong evidence for a pathophysiological link between meprin beta (zeige MEP1B Proteine) and urinary excretion of cleaved nidogen-1 during cisplatin-induced acute kidney injury.
The C-terminal domains of mouse laminin gamma 1 (zeige LAMC1 Proteine) and nidogen 1 mediate interactions complex formation.
nidogen-1 is essential to provide an anti-angiogenic environment of differentiated vessels.
show that loss of nidogen 2 (zeige NID2 Proteine), but not of nidogen 1, promotes lung metastasis of melanoma cells. Histological and ultrastructural analysis of nidogen 1- and 2-deficient lungs did not reveal differences in morphology and ultrastructure of basement membrane
Basement membrane deposition of nidogen 1 but not nidogen 2 requires the nidogen binding module of the laminin gamma1 chain.
This study demonstrates that nidogen-1 is essential for maintenance of normal hippocampal excitability and synaptic plasticity.
Results suggest a non-structural role for nidogen 1 in wound repair.
short arm region of laminin-5 gamma2 chain: structure, mechanism of processing and binding to heparin, nidogen-1, fibulin-1 (zeige FBLN1 Proteine) and fibulin-2 (zeige FBLN2 Proteine)
Specific ablation of the nidogen-binding site in the laminin gamma1 chain interferes with kidney and lung development.
Results demonstrated that NID1 was a mesenchymal associated gene and its high expression was significantly correlated with shorter overall survival of ovarian cancer patients. The study presents evidence that NID1 promotes the migration, invasion and chemoresistance of ovarian cancer cells via EMT (zeige ITK Proteine) and its molecular mechanism involves the activation of ERK/MAPK (zeige MAPK1 Proteine) signaling.
Nidogen 1 (NID1) was confirmed to promote lung metastasis of breast cancer and melanoma.
nidogen-1 degraded by CatS can be quantified in serum by the NIC (zeige NCSTN Proteine) assay. The current data strongly suggest that cathepsin-S (zeige CTSS Proteine) degradation of nidogen-1 is strongly associated with NSCLC, which needs validation in larger clinical cohorts.
Differential protein expression of collagen IV (zeige COL4 Proteine), laminin alpha2, and nidogen-1 indicated basal lamina remodeling develops in ischemic failing versus nonfailing human hearts.
NID1 was confirmed as a target gene of MiR (zeige MLXIP Proteine)-192/215 in Hirschsprung's disease patients.
Increase of NID1 protein expression is associated with endometrial cancer invasion.
The cleavage of nidogen-1 and -2 is partially inhibited in human tumor samples.
results demonstrate that mutation in either NID1 or LAMC1 (zeige LAMC1 Proteine) disrupts the interaction NID1-LAMC1 (zeige LAMC1 Proteine) complex; findings implicate the extracellular matrix in the pathogenesis of Dandy-Walker spectrum disorders
Cleavage of nidogen-1 by cathepsin S (zeige CTSS Proteine) impairs its binding to basement membrane partners
NID1 gene is a biologically plausible locus for nevogenesis and melanoma development
This gene encodes a member of the nidogen family of basement membrane glycoproteins. The protein interacts with several other components of basement membranes, and may play a role in cell interactions with the extracellular matrix.
, nidogen (enactin)
, Nidogen precursor (Entactin)
, entactin 1
, nidogen (entactin)