Neutral Sphingomyelinase (N-SMase) Activation Associated Factor Proteine (NSMAF)

NSMAF encodes a WD-repeat protein that binds the cytoplasmic sphingomyelinase activation domain of the 55kD tumor necrosis factor receptor. Zusätzlich bieten wir Ihnen Neutral Sphingomyelinase (N-SMase) Activation Associated Factor Antikörper (52) und Neutral Sphingomyelinase (N-SMase) Activation Associated Factor Kits (9) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
NSMAF 8439 Q92636
NSMAF 18201 O35242
Ratte NSMAF NSMAF 353233  
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Top Neutral Sphingomyelinase (N-SMase) Activation Associated Factor Proteine auf antikoerper-online.de

Showing 5 out of 5 products:

Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Insektenzellen Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 70 Days
$13,984.89
Details
Insektenzellen Maus His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 70 Days
$13,984.89
Details
HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Anmelden zum Anzeigen Verfügbar
$814.00
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Wheat germ Human GST tag 10 μg Anmelden zum Anzeigen 11 bis 12 Tage
$414.29
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Escherichia coli (E. coli) Human GST tag,His tag 100 μg Anmelden zum Anzeigen 15 bis 18 Tage
$656.00
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NSMAF Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Human , , ,
, , ,
Mouse (Murine)

Weitere Proteine zu Neutral Sphingomyelinase (N-SMase) Activation Associated Factor (NSMAF) Interaktionspartnern

Human Neutral Sphingomyelinase (N-SMase) Activation Associated Factor (NSMAF) Interaktionspartner

  1. The interaction of FAN with receptor for activated C-kinase 1 (RACK1 (zeige GNB2L1 Proteine)) appears to be dependent on the folding of the WD repeats into a secondary structure, because no linear binding motifs are identified in the WD-repeat region of FAN.

  2. sphingolipid activator proteins like domain may stabilize the fold of acid sphingomyelinase (zeige SMPD1 Proteine)

  3. Regulation of NSMAF by TNF-alpha (zeige TNF Proteine) involves PRKCD (zeige PKCd Proteine) in lung epithelial cells.

Mouse (Murine) Neutral Sphingomyelinase (N-SMase) Activation Associated Factor (NSMAF) Interaktionspartner

  1. FAN through promoting melanoma cellular motility and tumour invasiveness is critical for the tumour-promoting action of tumor necrosis factor (zeige TNF Proteine).

  2. FAN is not implicated in the development of methionine and choline deficient diet-induced non-alcoholic steatohepatitis.

  3. the role of FAN and IL-6 (zeige IL6 Proteine) in the inflammatory response initiated by endotoxin, implicating TNFalpha (zeige TNF Proteine)

  4. FAN mediates activation of N-SMase as well as regulation of lysosome size by signaling pathways that operate independent from activation/membrane recruitment of PKC.

  5. The results of this study suggest that PH-mediated plasma membrane targeting of FAN is critically involved in tumor necrosis factor (zeige TNF Proteine)-induced Cdc42 (zeige CDC42 Proteine) activation and cytoskeleton reorganization.

  6. This is the first report to demonstrate that TNFalpha (zeige TNF Proteine)-induced sickness behavior is fully mediated by TNF-R1 (zeige TNFRSF1A Proteine) and that the adaptor protein FAN is a necessary intracellular intermediate for sickness behavior

  7. these results indicate the involvement of FAN in TNF (zeige TNF Proteine)-induced gene expression and leukocyte recruitment, contributing to the establishment of the specific immune response.

Neutral Sphingomyelinase (N-SMase) Activation Associated Factor (NSMAF) Protein Überblick

Protein Überblick

This gene encodes a WD-repeat protein that binds the cytoplasmic sphingomyelinase activation domain of the 55kD tumor necrosis factor receptor. This protein is required for TNF-mediated activation of neutral sphingomyelinase and may play a role in regulating TNF-induced cellular responses such as inflammation. Alternative splicing results in multiple transcript variants.

Genbezeichner und Symbole assoziert mit NSMAF

  • protein FAN (EDI_035100)
  • neutral sphingomyelinase activation associated factor (NSMAF)
  • neutral sphingomyelinase (N-SMase) activation associated factor (Nsmaf)
  • neutral sphingomyelinase activation associated factor (Nsmaf)
  • AA959567 Protein
  • C630007J05 Protein
  • Fan Protein

Bezeichner auf Proteinebene für NSMAF

protein FAN , factor associated with N-SMase activation , factor associated with neutral sphingomyelinase activation

GENE ID SPEZIES
5884688 Entamoeba dispar SAW760
8439 Homo sapiens
18201 Mus musculus
353233 Rattus norvegicus
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