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NTS encodes a common precursor for two peptides, neuromedin N and neurotensin.
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Cat (Feline) Polyclonal Neurotensin Primary Antibody für IEM, ICC - ABIN617885
Woulfe, Beaudet: Neurotensin terminals form synapses primarily with neurons lacking detectable tyrosine hydroxylase immunoreactivity in the rat substantia nigra and ventral tegmental area. in The Journal of comparative neurology 1992
Show all 93 Pubmed References
Human Polyclonal Neurotensin Primary Antibody für IF (p), IHC (p) - ABIN719126
Sakumoto, Hayashi, Saito, Kanahara, Kizaki, Iga: Comparison of the global gene expression profiles in the bovine endometrium between summer and autumn. in The Journal of reproduction and development 2015
NTS may be an important stimulus to promote hepatocellular carcinoma invasion and metastasis both in vitro and in vivo.
Higher concentrations of proneurotensin are associated with a greater risk of incident cardiovascular events in the community. This association did not vary according to sex, baseline low-density lipoprotein, or sortilin (zeige SORT1 Antikörper) receptor 1 genotype.
sortilin (zeige SORT1 Antikörper) is a PIP3 binding protein with binding likely to occur at the C-terminal neurotensin binding site, and is a competitor of neurotensin
pretreatment of gastric cancer cells with NTR1 (zeige TFIP11 Antikörper) inhibitor SR48692 was shown to significantly inhibit the NT-mediated MMP-9 (zeige MMP9 Antikörper) activity, cell invasion, and migration
NTS/IL-8 (zeige IL8 Antikörper)/CXCR1 (zeige CXCR1 Antikörper)/STAT3 (zeige STAT3 Antikörper) signaling is crucial for the maintenance of stem-like traits in glioblastoma stem cells .
NTS/NTSR1 (zeige NTSR1 Antikörper) complex enhances breast tumor aggressiveness via EGFR (zeige EGFR Antikörper)/HER2 (zeige ERBB2 Antikörper)/HER3 (zeige ERBB3 Antikörper) pathway.
Neurotensin and its receptor NTSR1 (zeige NTSR1 Antikörper) causes EGFR (zeige EGFR Antikörper), HER2 (zeige ERBB2 Antikörper) and HER3 (zeige ERBB3 Antikörper) over-expression and their autocrine/paracrine activation in lung adenocarcinomas, confirming responsiveness to erlotinib.
indicate that neurotensin is a direct target of the Wnt (zeige WNT2 Antikörper)/beta-catenin (zeige CTNNB1 Antikörper) pathway and may be a mediator for neuroendocrine tumor cell growth
The antimicrobial peptide (zeige CAMP Antikörper) neurotensin has activity against invasive microbes.
Results show that both the neurotensin (NT) and the neurotensin 1 receptor hNTS1(321-344)fragment present a 3D structure in complex.
The pigmented cells of the ocular ciliary epithelium release neurotensin (NT) in response to inducing agents, whereas the nonpigmented cells exhibit a significantly reduced NT secretion in response to inducers, leading to accumulation of the peptide.
Nts-leptin receptor (zeige LEPR Antikörper) neurons are important neuronal hubs within the lateral hypothalamic area for hormone-mediated control of ingestive and locomotor behaviors.
Data (including data from studies in transgenic mice) suggest Nts, glucagon-like peptide I (zeige GCG Antikörper), and peptide YY are closely co-expressed/co-secreted within enteroendocrine cells in ileum mucosa; however, Nts is stored in distinct/separate secretory granules.
The roles of neurotensin and its receptor NTR-1 on sperm capacitation and acrosome reaction in mice are reported.
These observations suggest the importance of neurotensin in maintaining activity of orexin (zeige OX Antikörper) neurons.
a lineage of mature enteroendocrine cells have the ability to coexpress members of a group of functionally related peptides: CCK (zeige CCK Antikörper), secretin (zeige SECR Antikörper), GIP (zeige GIP Antikörper), GLP-1 (zeige GCG Antikörper), PYY, and neurotensin
Neurotensin knock-out mice do not differ from their wild-type or heterozygous littermates in either baseline or acute cocaine-stimulated locomotor activity.
Neurotensin increases EGF (zeige EGF Antikörper) expression in skin dendritic cells.
NT acutely regulates D2 autoreceptor function and DA neuron excitability through PKC (zeige PKC Antikörper)-mediated phosphorylation of the D2R (zeige DRD2 Antikörper), leading to heterologous receptor desensitization.
although neurotensin neurons in the anteroventral periventricular nucleus are targets for regulation by E(2), neurotensin does not appear to play a direct role in generating the GnRH/LH surge in the mouse
neurotensin has a role in chronic mitogen-activated protein kinase (zeige MAPK1 Antikörper) activation and cancer progression
Human, pig, and frog NT and [Gln(4)]NT and [D-Tyr (zeige TYR Antikörper)(11)]NT adsorbed to the silver surface via the tyrosine ring, the oxygen atom of the deprotonated phenol group of Tyr (zeige TYR Antikörper)(11), and the -CH(2 (zeige Acyp1 Antikörper))- unit(s), most probably of Tyr (zeige TYR Antikörper)(11), Arg(9), and/or Leu(13 (zeige IFITM1 Antikörper)).
This gene encodes a common precursor for two peptides, neuromedin N and neurotensin. Neurotensin is a secreted tridecapeptide, which is widely distributed throughout the central nervous system, and may function as a neurotransmitter or a neuromodulator. It may be involved in dopamine-associated pathophysiological events, in the maintenance of gut structure and function, and in the regulation of fat metabolism. Tissue-specific processing may lead to the formation in some tissues of larger forms of neuromedin N and neurotensin. The large forms may represent more stable peptides that are also biologically active.
, neurotensin/neuromedin N
, neuromedin N