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NETO2 encodes a predicted transmembrane protein containing two extracellular CUB domains followed by a low-density lipoprotein class A (LDLa) domain. Zusätzlich bieten wir Ihnen NETO2 Antikörper (55) und viele weitere Produktgruppen zu diesem Protein an.
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upregulation of NETO2 gene is first stipulated by the isoform 1 (NM_018092.4), and the probable mechanism of its activation is associated with the increased expression of SAP30 transcription factor.
NETO2 may be involved in colorectal cancer progression, but is not directly associated with epithelial-mesenchymal transition
Results suggested that the extracellular N-terminal region including the two CUB domains was largely responsible for the distinct regulatory effects of Neto1 and Neto2 on the desensitization properties of GluK1 homomeric receptors
NETO2 upregulation could serve as a potential biomarker for the prediction of advanced tumor progression and unfavorable prognosis in patients with colorectal carcinoma.
Determination of the neuropilin and tolloid-like protein 2 signal peptide cleavage site by N-terminal sequencing.
Rat neto2 plays a role in glutamate signaling in the brain by modulating the function of kainate receptors.
KAR-mediated excitation of interneurons is contingent upon Neto1 because kainate yields comparable effects in Neto2 knockouts and wild-types but fails to excite interneurons or recruit inhibition in Neto1 knockouts.
Pain-transducing peripheral sensory neurons of the dorsal root ganglia (DRG) express kainate receptors (KARs), a subfamily of glutamate receptors that modulate neurite outgrowth and regulate glutamate release at the DRG-dorsal horn synapse.
These results establish critical roles for Neto auxiliary subunits controlling Kainate receptor properties and synaptic incorporation.
Neto2 interacts with the scaffolding protein GRIP and regulates synaptic abundance of kainate receptors.
Loss of the Neto2:KCC2 interaction reduced KCC2-mediated Cl(-) extrusion, resulting in decreased synaptic inhibition in hippocampal neurons.
Btcl2 mRNA was observed restrictively in brain throughout embryonic and postnatal stages; expressed in the pontine nucleus and subplate, which are required for establishing the neuronal circuit formation.
This gene encodes a predicted transmembrane protein containing two extracellular CUB domains followed by a low-density lipoprotein class A (LDLa) domain. A similar gene in rats encodes a protein that modulates glutamate signaling in the brain by regulating kainate receptor function. Expression of this gene may be a biomarker for proliferating infantile hemangiomas. A pseudogene of this gene is located on the long arm of chromosome 8. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
neuropilin (NRP) and tolloid (TLL)-like 2
, neuropilin- and tolloid-like protein 2
, brain-specific transmembrane protein containing 2 CUB and 1 LDL-receptor class A domains protein 2
, neuropilin and tolloid-like protein 2
, neuropilin and tolloid like-2