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The protein encoded by NEDD9 is a member of the CRK-associated substrates family. Zusätzlich bieten wir Ihnen NEDD9 Kits (7) und NEDD9 Proteine (6) und viele weitere Produktgruppen zu diesem Protein an.
Showing 10 out of 67 products:
Mouse (Murine) Monoclonal NEDD9 Primary Antibody für ICC, FACS - ABIN108572
ONeill, Golemis: Proteolysis of the docking protein HEF1 and implications for focal adhesion dynamics. in Molecular and cellular biology 2001
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Human Monoclonal NEDD9 Primary Antibody für ICC, IF - ABIN151219
Pugacheva, Golemis: The focal adhesion scaffolding protein HEF1 regulates activation of the Aurora-A and Nek2 kinases at the centrosome. in Nature cell biology 2005
Show all 3 Pubmed References
Human Monoclonal NEDD9 Primary Antibody für IF, ELISA - ABIN561951
Li, Grupe, Rowland, Holmans, Segurado, Abraham, Jones, Catanese, Ross, Mayo, Martinez, Hollingworth, Goate, Cairns, Racette, Perlmutter, ODonovan, Morris, Brayne, Rubinsztein, Lovestone, Thal, Owen et al.: Evidence that common variation in NEDD9 is associated with susceptibility to late-onset Alzheimer's and Parkinson's disease. ... in Human molecular genetics 2008
NEDD9 deregulated Smad7 (zeige SMAD7 Antikörper) expression to inhibit Smad (zeige SMAD1 Antikörper) signaling and binding to the FAK (zeige PTK2 Antikörper)-Src (zeige SRC Antikörper)-Crk (zeige CRK Antikörper) complex which is proposed that this is the mechanism by which NEDD9 induced greater sphere formation in cancer stem cells properties.
HIP2 (zeige UBE2K Antikörper) regulates mitotic spindle alignment. SHIP2 (zeige INPPL1 Antikörper) is expressed in G1 phase, whereas Aurora A kinase (zeige AURKA Antikörper) is enriched in mitosis. SHIP2 (zeige INPPL1 Antikörper) binds Aurora A kinase (zeige AURKA Antikörper) and the scaffolding protein HEF1 and promotes their basolateral localization at the expense of their luminal expression connected with cilia resorption.
The protein expression level of NEDD9 is higher in esophageal carcinoma tissues than that in adjacent normal tissues. Knockdown of NEDD9 expression can restrain the proliferation, invasion and migration of EC109 cells.
NEDD9 was able to partially overcome the inhibitory effects of miR (zeige MLXIP Antikörper)-203 on colorectal cancer cell colony formation and invasion.
Increased NEDD9 expression is associated with metastatic endometrial and lung cancers.
NEDD9 has an essential role in development as well as in neoplastic cell proliferation, apoptosis, adhesion, migration and invasion. (Review)
The presence of the dna fragment in the NSCLC-N6-L16 (zeige MRPL16 Antikörper) cell ChIP assays demonstrated a physical link between NEDD9 and p53 (zeige TP53 Antikörper).
siRNA suppression of NEDD9 inhibits proliferation and enhances apoptosis in renal cell carcinoma (zeige MOK Antikörper).
Serum NEDD9 was elevated in gastric cancer patients and had an unfavorable prognostic effect.
BCAR3 (zeige BCAR3 Antikörper) is an essential interactor and mediator of HEF1-induced migration.
a new role for Cas-L in T-cell activation, is reported.
These results suggest that Nedd9 is a Smad2 (zeige SMAD2 Antikörper)/3 target gene implicated in RANKL (zeige TNFSF11 Antikörper)-induced osteoclastogenesis.
NEDD9 is required for the maintenance of dendritic spines in the hippocampus.
Thus the RARE upstream of the Nedd9 2B promoter is necessary for much of the endogenous gene expression during early development as well as ectopic expression in response to atRA.
suggest that Cas-L/NEDD9 plays a pivotal role in the pathophysiology of CIA (zeige NCOA5 Antikörper), and that Cas-L/NEDD9 may be a potential molecular target for the treatment of RA
Data indicate that Src kinase (zeige CSK Antikörper) modulates the transit time of NEDD9 (neural precursor cell expressed developmentally down-regulated gene 9) at focal adhesion sites.
These results indicated an important modifier action of Nedd9 on autosomal dominant polycystic kidney disease pathogenesis involving failure to activate Aurora-A (zeige AURKA Antikörper).
these results indicate a functional requirement for NEDD9 in the growth of mammary cancer progenitor cells
Tyrosine Y189 in the substrate domain of the adhesion docking protein NEDD9 is conserved with p130Cas (zeige BCAR1 Antikörper) Y253 and regulates NEDD9-mediated migration and focal adhesion dynamics.
The protein encoded by this gene is a member of the CRK-associated substrates family. Members of this family are adhesion docking molecules that mediate protein-protein interactions for signal transduction pathways. This protein is a focal adhesion protein that acts as a scaffold to regulate signaling complexes important in cell attachment, migration and invasion as well as apoptosis and the cell cycle. This protein has also been reported to have a role in cancer metastasis. Alternative splicing results in multiple transcript variants.
neural precursor cell expressed, developmentally down-regulated 9
, enhancer of filamentation 1 homolog
, Cas scaffolding protein family member 2
, Crk-associated substrate related protein Cas-L
, Enhancer of filamentation 1 p55
, cas-like docking
, enhancer of filamentation 1
, neural precursor cell expressed developmentally down-regulated protein 9
, p130Cas-related protein
, renal carcinoma antigen NY-REN-12
, neural precursor cell expressed, developmentally down-regulated gene 9
, CRK-associated substrate-related protein
, Crk-associated substrate lymphocyte-specific protein