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Stress-activated kinase involved in tolerance to glucose starvation. Zusätzlich bieten wir Ihnen NUAK Family, SNF1-Like Kinase, 2 Proteine (9) und und viele weitere Produktgruppen zu diesem Protein an.
Showing 10 out of 79 products:
Human Polyclonal NUAK2 Primary Antibody für ICC, IF - ABIN4340883
Kim, Lee, Chae, Kang, Lee, Oh, Kim, Kim, Kim: Association between phosphorylated AMP-activated protein kinase and MAPK3/1 expression and prognosis for patients with gastric cancer. in Oncology 2013
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Human Polyclonal NUAK2 Primary Antibody für ELISA, WB - ABIN543678
Lefebvre, Bai, Shahmolky, Sharma, Poon, Drucker, Rosen: Identification and characterization of a novel sucrose-non-fermenting protein kinase/AMP-activated protein kinase-related protein kinase, SNARK. in The Biochemical journal 2001
Human Polyclonal NUAK2 Primary Antibody für WB - ABIN391234
Yamamoto, Takashima, Shintani, Yamazaki, Seguchi, Nakano, Higo, Kato, Liao, Asano, Minamino, Matsumura, Takeda, Kitakaze: Identification of a novel substrate for TNFalpha-induced kinase NUAK2. in Biochemical and biophysical research communications 2008
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Data (including data from studies in knockout and transgenic mice) suggest that NUAK2/SNARK is involved in both adipose inflammation and energy metabolism in adipocytes; additionally, genome-wide association studies suggest that 2 SNPs in NUAK2/SNARK (rs4682880, rs4682676) are associated with obesity in women.
miR143 inhibited the proliferation, migration and invasion of the glioblastoma cells by degrading NUAK2 in glioblastoma.
Sucrose non-fermenting AMPK related kinase/Pentraxin 3 combined role in immunometabolic signaling and DNA damage response is proposed to accelerate cardiovascular complications in systemic lupus erythematosus patients
NUAK2 silencing and inactivation of the PI3K pathway efficiently controlled CDK2 expression, whereas CDK2 inactivation specifically abrogated the growth of NUAK2-amplified and PTEN-deficient melanoma cells.
The AMPK-related kinase SNARK regulates hepatitis C virus replication and pathogenesis through enhancement of TGF-beta signaling.
Activation of AMP-activated protein kinase protects the integrity of the blood-brain barrier by suppressing the induction of NADPH oxidase-derived superoxide anions.
Considers possible roles of NUAK2 in tumorigenesis in general and suggest that NUAK2 has pivotal roles in acral melanomagenesis.
MLCP (myosin light chain phosphatase) activation is counteracted by a previously unrecognized association between MRIP (myosin phosphatase Rho-interacting protein) and the inducible kinase NUAK2
This study further supports the importance of NUAK2 in cancer development and tumor progression, while AMPK has antioncogenic properties.
Data show that SNARK is activated by muscle contraction and is a unique mediator of contraction-stimulated glucose transport in skeletal muscle.
SNARK is an NF-kappaB-regulated anti-apoptotic gene that contributes to the tumor-promoting activity of CD95 in apoptosis-resistant tumor cells
These data suggests different phosphorylation and regulation of MYPT1 activity by NUAK2.
EBV LMP1 upregulated the expression of SNARK; SNARK expression increased drug resistance in response to doxorubicin increased of cancer cell survival
The nuclear localizing SNARK altered transcriptome profiles and a considerable part of these alterations were canceled by the mutation of NLS, suggesting the ability of SNARK to modulate gene expression dependent on its nuclear localization.
Skeletal muscle SNARK expression is increased in human obesity, and in response to metabolic stressors, but not type 2 diabetes. Partial SNARK depletion failed to modify either glucose or lipid metabolism.
This study describes the cloning and characterization of the rat SNARK homolog, mapping of the human SNARK gene to 1q32, and a potential functional role as mediator of the cellular response to metabolic stress.
Using liver cancer as a model, NUAK2 was identified as an essential mediator of YAP-driven hepatomegaly and tumorigenesis in vivo.
Data (including data from studies in knockout and transgenic mice) suggest that Nuak2/Snark is involved in both adipose inflammation and energy metabolism in white/brown adipocytes; Nuak2/Snark appears to regulate thermogenesis in brown adipocytes.
These findings reveal a critical role for SNARK in myocyte survival and the maintenance of muscle mass with age.
NUAK1 and NUAK2 complementarily function in the apical constriction and apico-basal elongation that associate with the dorsolateral hinge point formation in cephalic neural plate during the 5- to 10-somite stages.
Obesity was a risk factor for colorectal tumorigenesis in Snark(+/-) mice model.
Stress-activated kinase involved in tolerance to glucose starvation. Induces cell-cell detachment by increasing F-actin conversion to G-actin. Expression is induced by CD95 or TNF-alpha, via NF-kappa-B. Protects cells from CD95-mediated apoptosis and is required for the increased motility and invasiveness of CD95- activated tumor cells. Able to phosphorylate 'Ser-464' of LATS1 (By similarity).
NUAK family SNF1-like kinase 2
, SNF1/AMP activated protein kinase
, SNF1/AMP kinase-related kinase
, omphalocele kinase 2
, SNF1/AMP-activated protein kinase