NEL-Like 1 (Chicken) Proteine (NELL1)

NELL1 encodes a cytoplasmic protein that contains epidermal growth factor (EGF)-like repeats. Zusätzlich bieten wir Ihnen NEL-Like 1 (Chicken) Antikörper (38) und NEL-Like 1 (Chicken) Kits (9) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
NELL1 338352 Q2VWQ2
NELL1 4745 Q92832
NELL1 81733 Q62919
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Top NEL-Like 1 (Chicken) Proteine auf

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Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Insektenzellen Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 70 Days
Insektenzellen Maus His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 70 Days
Human Cells Human His tag   50 μg Anmelden zum Anzeigen 4 Days
Wheat germ Human GST tag 10 μg Anmelden zum Anzeigen 11 bis 12 Tage
Human Cells Human His tag   10 μg Anmelden zum Anzeigen 15 bis 16 Tage
Hefe Ratte His tag   1 mg Anmelden zum Anzeigen 60 bis 71 Tage
HEK-293 Cells Human His tag   10 μg Anmelden zum Anzeigen 8 bis 11 Tage

NELL1 Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Mouse (Murine)

Human , , ,
Rat (Rattus)

Weitere Proteine zu NEL-Like 1 (Chicken) (NELL1) Interaktionspartnern

Mouse (Murine) NEL-Like 1 (Chicken) (NELL1) Interaktionspartner

  1. Nell-1-haploinsufficient mice (zeige WNT2 Proteine)have normal s (zeige CTNNB1 Proteine)keletal development but undergo age-related osteoporosis, characterized by a reduction in osteoblast:osteoclast ratio and increased bone fragility.

  2. These results suggest that an oligomerization-induced conformational change in the C-terminal region of NELL1 is important for the efficient mediation of cell adhesion and spreading by NELL1.

  3. Nell-1 might play a role in ameloblast and odontoblast differentiation, secretion and mineralization of the extracellular enamel matrix, molar crown morphogenesis, as well as root formation during the entire development period.

  4. NELL-1 protein promotes cell adhesion in ST2 cells.

  5. The C-terminal region of NELL1 mediates osteoblastic cell adhesion through integrin alpha3beta1

  6. data suggest Nell-1 is important growth factor for regulation of osteochondral differentiation regulating both Runx2 (zeige RUNX2 Proteine) and Sox9 (zeige SOX9 Proteine) expression in calvarium. Nell-1 is required for normal craniofacial membranous and endochondral skeletal development.

  7. These studies suggest that Nell-1 is a potent anti-adipogenic agent. Moreover, Nell-1 signaling may inhibit adipogenic differentiation via a Hedgehog (zeige SHH Proteine) dependent mechanism.

  8. Nfatc2 (zeige NFAT1 Proteine) likely plays an important role in Nell-1-mediated osteochondral differentiation in vitro and in vivo.

  9. Nell-1 supports continued osteoblastic differentiation and function in osteoblastic lineage cells during calvarial development. Nell-1 is a key functional, downstream mediator of Runx2 (zeige RUNX2 Proteine) osteogenic activity.

  10. A recessive, neonatal-lethal point mutation in the Nell1 gene causes cranial and skeletal defects.

Human NEL-Like 1 (Chicken) (NELL1) Interaktionspartner

  1. NELL1 variant is associated with tobacco- and HPV-mediated oral oncogenesis.

  2. Results demonstrate that NELL1 is differentially expressed in fusion-positive alveolar rhabdomyosarcoma (ARMS) and in embryonal rhabdomyosarcoma (ERMS) samples, and they show that this transcriptional difference partially depends on genomic DNA methylation (zeige HELLS Proteine). The study also found that high NELL1 levels are correlated with negative RMS prognostic factors and with poor tumor outcomes.

  3. lipoaspirate-derived hPSCs present a novel and abundant cell source of MSCs for cartilage regeneration, and the combinatorial application of NELL-1, TGF-beta3 (zeige TGFB3 Proteine), and BMP-6 (zeige BMP6 Proteine) with hPSCs may remarkably enhance and accelerate cartilage repair.

  4. establish the feasibility of combining NELL-1 with BMP2 (zeige BMP2 Proteine) to improve clinical bone regeneration and provide mechanistic insight into canonical Wnt (zeige WNT2 Proteine) pathway activity during NELL-1 and BMP2 (zeige BMP2 Proteine) osteogenesis

  5. Data suggest that TSPN (N-terminal thrombospondin-1-like (zeige THBS1 Proteine)) domain of NELL1 exhibits major heparin-binding sites which may be involved in interaction of NELL1 with cell surface heparan sulfate proteoglycans.

  6. NELL-1 signaling activates Wnt (zeige WNT2 Proteine)/beta-catenin (zeige CTNNB1 Proteine) signaling.

  7. We also detected lower relative expression of Nell-1 by real-time PCR. Furthermore, immunohistochemical analyses revealed that Nell-1 staining was less intense in cancer tissue relative to normal tissue and that the tumor cells had spread to the muscle

  8. CpG islands in the NELL1 and NELL2 promoters are hypermethylated in renal cell carcinoma.NELL1 and NELL2 protein expression is downregulated in clear cell renal carcinoma.

  9. NELL-1 demonstrates diffuse and reliable expression in benign but not malignant bone-forming skeletal tumors

  10. NELL1 overexpression greatly enhanced the osteogenic differentiation and mineral synthesis of iPSC-MSCs on RGD-grafted CPC scaffold for the first time.

NEL-Like 1 (Chicken) (NELL1) Protein Überblick

Protein Überblick

This gene encodes a cytoplasmic protein that contains epidermal growth factor (EGF)-like repeats. The encoded heterotrimeric protein may be involved in cell growth regulation and differentiation. A similar protein in rodents is involved in craniosynostosis. Two transcript variants encoding different isoforms have been found for this gene.

Genbezeichner und Symbole assoziert mit NEL-Like 1 (Chicken) Proteine (NELL1)

  • NEL-like 1 (Nell1)
  • neural EGFL like 1 (NELL1)
  • neural EGFL like 1 (Nell1)
  • B230343H07Rik Protein
  • IDH3GL Protein
  • l7R6 Protein
  • NRP1 Protein

Bezeichner auf Proteinebene für NEL-Like 1 (Chicken) Proteine (NELL1)

NEL-like protein 1 , protein kinase C-binding protein NELL1 , NELL-1 protein short isoform , nel-related protein 1 , neural epidermal growth factor-like 1

338352 Mus musculus
4745 Homo sapiens
81733 Rattus norvegicus
100336918 Bos taurus
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