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NDUFS6 encodes a subunit of the NADH oxidoreductase (complex I), which is the first enzyme complex in the electron transport chain of mitochondria. Zusätzlich bieten wir Ihnen NADH Dehydrogenase (Ubiquinone) Fe-S Protein 6, 13kDa (NADH-Coenzyme Q Reductase) Antikörper (56) und viele weitere Produktgruppen zu diesem Protein an.
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The studies identify for the first time that complex I deficiency as the result of interruption of Ndufs6 is an independent cause of renal impairment.
Data show that Ndufs6(gt/gt (zeige FABP6 Proteine)) mice are born healthy, attain normal weight and maturity, and are fertile, however, after 4 mo in males and 8 mo in females, Ndufs6(gt/gt (zeige FABP6 Proteine)) mice are at increased risk of cardiac failure and death.
CD147 appears to regulate complex I activity and apoptosis in malignant melanoma cells by interacting with mitochondrial NDUFS6.
NDUFS6, a complex I subunit gene not previously associated with complex I deficiency, was grossly underexpressed in t patient cell lines.
NDUFS6 is required for the assembly and stabilization of a portion of complex I that contains a number of subunits.
This gene encodes a subunit of the NADH oxidoreductase (complex I), which is the first enzyme complex in the electron transport chain of mitochondria. This complex functions in the transfer of electrons from NADH to the respiratory chain. The subunit encoded by this gene is one of seven subunits in the iron-sulfur protein fraction. Mutations in this gene cause mitochondrial complex I deficiency, a disease that causes a wide variety of clinical disorders, including neonatal disease and adult-onset neurodegenerative disorders.
, NADH dehydrogenase Fe-S protein 6
, NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial
, NADH-ubiquinone oxidoreductase 13 kDa-A subunit
, complex I-13kD-A
, NADH ubiquinone oxidoreductase
, NADH:ubiquinone oxidoreductase NDUFS6 subunit
, complex I 13kDa subunit A
, complex I, mitochondrial respiratory chain, 13-kD subunit
, mitochondrial complex I subunit NDUFS6