NADH Dehydrogenase (Ubiquinone) Fe-S Protein 1, 75kDa (NADH-Coenzyme Q Reductase) (NDUFS1) ELISA Kits

The protein encoded by NDUFS1 belongs to the complex I 75 kDa subunit family. Zusätzlich bieten wir Ihnen NDUFS1 Antikörper (87) und NDUFS1 Proteine (5) und viele weitere Produktgruppen zu diesem Protein an.

list all ELISA KIts Gen GeneID UniProt
Anti-Maus NDUFS1 NDUFS1 227197 Q91VD9
Anti-Ratte NDUFS1 NDUFS1 301458 Q66HF1
NDUFS1 4719 P28331
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Katalog Nr. Reaktivität Sensitivität Bereich Bilder Menge Anbieter Lieferzeit Preis Details
Human 0.127 ng/mL 0.31 ng/mL - 20 ng/mL 96 Tests Anmelden zum Anzeigen 13 bis 16 Tage
$736.84
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Weitere ELISA Kits für NDUFS1 Interaktionspartner

Mouse (Murine) NADH Dehydrogenase (Ubiquinone) Fe-S Protein 1, 75kDa (NADH-Coenzyme Q Reductase) (NDUFS1) Interaktionspartner

  1. The transition of mitochondrial complex I into the D-form in the absence of oxygen may represent a key event in promoting cardiac injury during I/R.

  2. lysosomal membrane permeability induced by TNFalpha plus cycloheximide, the release of lysosomal cathepsins and reactive oxygen species formation require the caspase-3-mediated cleavage of the p75 NDUFS1 subunit of respiratory complex I.

Human NADH Dehydrogenase (Ubiquinone) Fe-S Protein 1, 75kDa (NADH-Coenzyme Q Reductase) (NDUFS1) Interaktionspartner

  1. Results show that NDUFS1 protein and mRNA levels are down-regulated in lung neoplasm and correlate with poor overall survival.

  2. High NDUFS1 expression is associated with cognitive impairment in lung cancer.

  3. Results found nominal significant associations of 2 SNPs in the NDUFS1 gene and 4 SNPs in the NDUFS2 gene with early onset schizophrenia (EOS), but none of these associations survived the Bonferroni correction.

  4. Loss of FOXRED1, coupled with protein, choline and/or folate-deficient diets results in the depletion of glutathione, the dysregulation of nitric oxide metabolism and the peroxynitrite-mediated inactivation of complex I.

  5. NDUFS1 may confer susceptibility to schizophrenia in male subjects, acting as a causative factor for the severity of negative symptoms in schizophrenia.

  6. The presented clinical courses of NDUFV1 and NDUFS1 mutation-based complex I deficiencies are characterized by leukoencephalopathy or early death and expand the already heterogeneous phenotypic spectrum.

  7. Some mutations in NDUFS1 cause a milder phenotype with a more benign course despite the initial decompensation phase. Homozygosity for the c.755A > G missense mutation may correlate with the milder clinical picture in the patient.

  8. The peripheral leukocyte oxidative phosphorylation enzyme activity assay was found to be a reliable method for the diagnosis of mitochondrial diseases.

  9. A protein encoded by this locus was found to be differentially expressed in postmortem brains from patients with atypical frontotemporal lobar degeneration.

  10. homozygous c.1783A>G (p.Thr595Ala) mutation in NDUFS1 in two inbred siblings with isolated complex I deficiency associated to a progressive cavitating leukoencephalopathy

  11. data suggest that gamma oscillations are especially energy demanding and require both high complex I expression and strong functional performance of mitochondria.

  12. report 3 patients with low residual complex I activity who displayed novel mutations in the NDUFS1 gene. One mutation introduces a premature stop codon, 3 mutations cause a substitution of amino acids and another mutation a deletion of one amino acid.

  13. Mutations in electron Transport Complex I is associated with Leber hereditary optic neuropathy failing to compensate for impaired oxidative phosphorylation.

  14. A patient with Leigh syndrome had a mutation in the NDUFS1 protein of Complex I of the Respiratory Chain. Identifying nuclear mutations will help us understand how molecular defects can lead to complex I deficiency.

  15. mutations in the NDUFS1 and NDUFS4 genes of complex I cause dysfunction in cellular oxidative metabolism

  16. This protein has been found differentially expressed in the Wernicke's Area from patients with schizophrenia.

Cow (Bovine) NADH Dehydrogenase (Ubiquinone) Fe-S Protein 1, 75kDa (NADH-Coenzyme Q Reductase) (NDUFS1) Interaktionspartner

  1. Data show that during NADH-ubiquinone oxidoreductase (Complex I) catalytic electron transfer from NADH to DBQ, the superoxide generation site was mostly shifted to the SQ.

  2. Data suggest that Q(Nf) plays a role in a "direct" redox-driven proton pump, while Q(Ns) triggers an "indirect" conformation-driven proton pump in NADH-ubiquinone oxidoreductase (complex I).

  3. Bovine heart NADH-ubiquinone oxidoreductase contains one molecule of ubiquinone with ten isoprene units as one of the cofactors

NDUFS1 Antigen-Profil

Beschreibung des Gens

The protein encoded by this gene belongs to the complex I 75 kDa subunit family. Mammalian complex I is composed of 45 different subunits. It locates at the mitochondrial inner membrane. This protein has NADH dehydrogenase activity and oxidoreductase activity. It transfers electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. This protein is the largest subunit of complex I and it is a component of the iron-sulfur (IP) fragment of the enzyme. It may form part of the active site crevice where NADH is oxidized. Mutations in this gene are associated with complex I deficiency. Several transcript variants encoding different isoforms have been found for this gene.

Genbezeichner und Symbole assoziert mit NDUFS1

  • NADH dehydrogenase (ubiquinone) Fe-S protein 1 (Ndufs1) Antikörper
  • NADH:ubiquinone oxidoreductase core subunit S1 (Ndufs1) Antikörper
  • NADH:ubiquinone oxidoreductase core subunit S1 (NDUFS1) Antikörper
  • 5830412M15Rik Antikörper
  • 9930026A05Rik Antikörper
  • CI-75k Antikörper
  • CI-75Kd Antikörper
  • PRO1304 Antikörper

Bezeichner auf Proteinebene für NDUFS1

CI-75kD , NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial , complex I-75kD , NADH dehydrogenase (ubiquinone) Fe-S protein 1, 75kDa , complex I 75kDa subunit , complex I, mitochondrial respiratory chain, 75-kD subunit , mitochondrial NADH-ubiquinone oxidoreductase 75 kDa subunit

GENE ID SPEZIES
227197 Mus musculus
301458 Rattus norvegicus
4719 Homo sapiens
478880 Canis lupus familiaris
288380 Bos taurus
100516402 Sus scrofa
459896 Pan troglodytes
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