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The encoded protein is a subunit of the hydrophobic protein fraction of the NADH:ubiquinone oxidoreductase (complex 1), the first enzyme complex in the electron transport chain located in the inner mitochondrial membrane, and may be involved in regulating complex I activity or its assembly via assistance in redox processes.
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The authors use green fluorescent-tagged complex I subunits to determine the kinetics of assembly. Tagged human NDUFA2 may incorporate into the holo-complex I enzyme as an assembly intermediate or as free monomers. The authors conclude that nuclear-encoded subunits incorporate into the holo-enzyme in a subunit-specific manner.
The authors determine the NMR structur (zeige TXN Proteine)e of the oxidized human NDUFA2 protein, also known as B8 (zeige TXN Proteine), and report that its structur (zeige TXN2 Proteine)e and redox potential is similar to that of thioredoxins. The highly conserved residues on the surface most likely form the protein-protein interaction site of this subunit with the large multimeric complex I.
differentially expressed in the brains of four mice strains; expression pattern follows ethanol preference of the strains [(NADH-ubiquinone oxidoreductase B8 subunit]
A novel mechanism of lipoteichoic acid (LTA (zeige LTA Proteine))-induced cytokine induction in human peripheral blood cells involves uptake of LTA (zeige LTA Proteine) and subsequent intracellular recognition driven by Toll (zeige TLR4 Proteine)-like receptor (TLR)2, TLR6 (zeige TLR6 Proteine), and CD14.
solution structure shows a thioredoxin (zeige TXN Proteine) fold with highest similarities to the human thioredoxin (zeige TXN Proteine) mutant C73S and thioredoxin 2 (zeige TXN2 Proteine) from Anabeana sp
The encoded protein is a subunit of the hydrophobic protein fraction of the NADH:ubiquinone oxidoreductase (complex 1), the first enzyme complex in the electron transport chain located in the inner mitochondrial membrane, and may be involved in regulating complex I activity or its assembly via assistance in redox processes. Mutations in this gene are associated with Leigh syndrome, an early-onset progressive neurodegenerative disorder. Alternative splicing results in multiple transcript variants.
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2
, NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 2, 8kDa
, NADH-ubiquinone oxidoreductase B8 subunit
, OXPHOS complex I B8 subunit
, complex I-B8
, NADH-ubiquinone oxidoreductase subunit CI-B8
, complex I B8 subunit
, NADH-ubiquinone oxidoreductase complex