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APEH encodes the enzyme acylpeptide hydrolase, which catalyzes the hydrolysis of the terminal acetylated amino acid preferentially from small acetylated peptides. Zusätzlich bieten wir Ihnen APEH Antikörper (64) und APEH Proteine (4) und viele weitere Produktgruppen zu diesem Protein an.
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Although APEH is primarily localized in the cytoplasm, a sub-fraction of this enzyme is sequestered at sites of nuclear damage following UVA irradiation or following oxidative stress. APEH interacts with the amino-terminal domain of XRCC1, and APEH facilitates both single-strand break repair and cell survival following exposure to H2O2. Thus, APEH as a novel proteolytic component of the DNA damage response.
APEH polymorphism has significant influence on valproic acid pharmacokinetics in Chinese population
Studies indicate that the cylindromatosis/turban tumor syndrome gene (CYLD) ranked highest, followed by acylaminoacyl-peptidase (APEH), dystroglycan (DAG1), macrophage-stimulating protein (MST1) and ubiquitin-specific peptidase 4 (USP4).
His507 is an important residue that is probably involved in the formation of the 3-dimensional structure (acylaminoacyl peptidase)
crystallographic analysis of porcine acylaminoacyl peptidase
This gene encodes the enzyme acylpeptide hydrolase, which catalyzes the hydrolysis of the terminal acetylated amino acid preferentially from small acetylated peptides. The acetyl amino acid formed by this hydrolase is further processed to acetate and a free amino acid by an aminoacylase. This gene is located within the same region of chromosome 3 (3p21) as the aminoacylase gene, and deletions at this locus are also associated with a decrease in aminoacylase activity. The acylpeptide hydrolase is a homotetrameric protein of 300 kDa with each subunit consisting of 732 amino acid residues. It can play an important role in destroying oxidatively damaged proteins in living cells. Deletions of this gene locus are found in various types of carcinomas, including small cell lung carcinoma and renal cell carcinoma.
, acyl-peptide hydrolase
, acylamino-acid-releasing enzyme
, oxidized protein hydrolase
, acylpeptide hydrolase
, N-acylpeptide hydrolase
, acylamino acid-releasing enzyme
, acylaminoacyl peptidase
, N-acylaminoacyl peptide hydrolase
, Acyl-peptide hydrolase
, LOW QUALITY PROTEIN: acylamino-acid-releasing enzyme
, acylamino-acid-releasing enzyme-like