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NAT6 encodes a member of the N-acetyltransferase family.
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Characterization of the murine hyaluronidase (zeige HAase Antikörper) gene region reveals complex organization and cotranscription of Hyal1 (zeige HYAL1 Antikörper) with downstream genes, Fus2 and Hyal3 (zeige HYAL3 Antikörper).
NAA80/NatH is dedicated to the post-translational N-terminal acetylation of processed actins. The structure of NAA80 reveals features like a positively charged catalytic groove perfectly suited to bind the acidic actin N-terminus. A cellular factor restricting NAA80 to processed actins is NatB, which co-translationally acetylates all cellular Met-starting N-termini with acidic amino acids at the second position.
NAT6/FUS-2 is the N-alpha acetyltransferase 80 (NAA80/NatH (zeige NAA15 Antikörper)) acting post-translationally and specifically on processed animal actins. This NAA80 mediated actin N-terminal acetylation is crucial for actin polymerization and depolymerization, and regulates the actin cytoskeleton and cell motility.
Characterization of the murine hyaluronidase (zeige HAase Antikörper) gene region reveals complex organization and cotranscription of Hyal1 (zeige HYAL1 Antikörper) with downstream genes, Fus2 and Hyal3 (zeige SPAM1 Antikörper).
newly identified polymorphism leads to a non-conservative amino acid change (R222W) located between the acetyltransferase and the proline-rich domains; analysis suggests no likely association between nasopharyngeal cancer and the FUS2 gene polymorphism
This gene encodes a member of the N-acetyltransferase family. N-acetyltransferases modify proteins by transferring acetyl groups from acetyl CoA to the N-termini of protein substrates. The encoded protein is a cytoplasmic N-acetyltransferase with a substrate specificity for proteins with an N-terminal methionine. This gene is located in the tumor suppressor gene region on chromosome 3p21.3 and the encoded protein may play a role in cancer. Alternatively spliced transcript variants encoding multiple isoforms have been observed. This gene overlaps and is on the same strand as hyaluronoglucosaminidase 3, and some transcripts of each gene share a portion of the first exon.
, protein fus-2
, protein fusion-2
, N-acetyltransferase 6