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The protein encoded by MSTN is a member of the bone morphogenetic protein (BMP) family and the TGF-beta superfamily. Zusätzlich bieten wir Ihnen Myostatin Kits (95) und Myostatin Proteine (70) und viele weitere Produktgruppen zu diesem Protein an.
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Human Monoclonal MSTN Primary Antibody für ELISA, WB - ABIN969306
Awano, Takeshima, Okizuka, Saiki, Yagi, Matsuo: Wide ranges of serum myostatin concentrations in Duchenne muscular dystrophy patients. in Clinica chimica acta; international journal of clinical chemistry 2008
Show all 2 Pubmed References
improving muscle growth in a fish species by mixing a classical strategy, such as compensatory growth, and a biotechnological approach, such as the use of recombinant proteins for inhibiting the biological actions of MSTN(Myostatin)
the expression of myostatin during development and the effects of its knock-down on various genes such as muscle regulatory transcription factors (MRFs), muscle-specific (zeige EIF3K Antikörper) proteins (MSP (zeige MST1 Antikörper)), and insulin (zeige INS Antikörper)-like growth factors (IGFs).
Epistatic analyses suggest a possible genetic interaction between Wnt (zeige WNT2 Antikörper)/beta-catenin (zeige CTNNB1 Antikörper) and Myostatin in regulation of slow and fast twitch muscle myofibrillogenesis
TALENs-mediated gene disruption of myostatin produces a larger phenotype of medaka with an apparently compromised immune system
Findings suggest that myostatin (MSTN) function is required for regulating the appropriate growth of skeletal muscle in medaka
GDF8 promotes ovarian cancer cell migration via ALK4 (zeige ACVR1B Antikörper)/5-SMAD2 (zeige SMAD2 Antikörper)/3-E-cadherin (zeige CDH1 Antikörper) signaling.
Results demonstrat that GDF8 stimulates the expression and secretion of CTGF (zeige CTGF Antikörper) in human granulosa cells and provide evidence that both proteins may play critical roles in the regulation of extracellular matrix formation in these cells.
These studies identify distinctive structural features of GDF11 (zeige GDF11 Antikörper) that enhance its potency, relative to GDF8; however, the biological consequences of these differences remain to be determined.
Serum myostatin levels were significantly decreased in heart failure patients and associated with lower extremity muscle wasting.
our data showed a virtual absence of the variant (K) allele in MSTN rs1805086 in Japanese population, and no differences in allele/genotype frequencies in ACTN3 (zeige ACTN3 Antikörper) rs1815739 among centenarians and healthy controls of this country.
MSTN, but not GDF11 (zeige GDF11 Antikörper), declines in healthy men throughout aging.
Multivariate regression analysis revealed that myostatin levels correlated significantly with tricuspid annular plane systolic excursion values and right ventricle myocardial performance index among the study patients
Study measured circulating myostatin levels in seven inherited muscle diseases using an immunoaffinity LC-MS/MS approach, found significantly lower serum myostatin concentrations in numerous muscle disease patient populations and the associations with clinical measurements suggests the potential utility of myostatin as a biomarker of genetic muscle disease progression
data indicated that serum myostatin concentration did not correlate with muscle and bone mass in postmenopausal women
Myostatin mRNA expression in skeletal muscle was significantly reduced compared with pre-exercise values at all time points with no difference between exercise intensity.
Mstn regulates Fndc5/Irisin (zeige FNDC5 Antikörper) expression and secretion through a novel miR (zeige MLXIP Antikörper)-34a-dependent post-transcriptional mechanism; loss of Mstn in mice leads to the increased Fndc5/Irisin (zeige FNDC5 Antikörper) expression, which contributes to the browning of white adipocytes
Axon diameter and myelin thickness were increased in motor axons of myostatin deficient animals.
These data illustrate the importance of lipids as a link by which MSTN deficiency can impact mitochondrial bioenergetics in skeletal muscle.
Myostatin inhibits eEF2K (zeige EEF2K Antikörper)-eEF2 (zeige EEF2 Antikörper) by regulating AMPK (zeige PRKAA1 Antikörper) to suppress protein synthesis.
These results demonstrate that a greater than additive effect is observed on the growth of skeletal muscle and in the reduction of body fat when myostatin is absent and IGF1 (zeige IGF1 Antikörper) is in excess (zeige RCC1 Antikörper), and that myostatin and IGF1 (zeige IGF1 Antikörper) regulate skeletal muscle size, myofibre type and gonadal fat through distinct mechanisms.
Mstn deficiency but not anti-myostatin blockade induces marked proteomic changes in mouse skeletal muscle.
GDF8 plays a significant regulatory role in bone formation and bone resorption
Genetic inactivation of myostatin increases maximal force and power, but in return it reduces muscle quality, particularly in male mice.
findings indicate that myostatin directly influences osteocyte function and thereby inhibits osteoblastic differentiation, at least in part, through the suppression of osteocyte-derived exosomal miR (zeige MLXIP Antikörper)-218, suggesting a novel mechanism in muscle-bone communication.
The 12-bp Mstn(Cmpt-dl1Abc) deletion decreases adiposity and improves whole body glucose uptake, insulin (zeige INS Antikörper) sensitivity, and (18)FDG (zeige SMUG1 Antikörper) uptake of skeletal muscle and white adipose tissue.
These results indicate that myostatin mediates maternal low protein diet-induced growth retardation, through epigenetic regulation involving FoxO3 (zeige FOXO3 Antikörper) and glucocorticoid receptor (zeige NR3C1 Antikörper) binding to its promoter.
Loss of MSTN increases muscle mass in pigs, which may help increase pork production for consumption in the future.
Data show that the protein level of The protein level of myostatin (MSTN) was decreased in the mutant cloned pigs compared with the wild-type controls.
Single nucleotide polymorphisms in the MYOD1 (zeige MYOD1 Antikörper) and GDF8 genes are associated with genetic transcription during myogenesis in pigs.
The level of myostatin inversely correlated with miR (zeige MYLIP Antikörper)-27a in fat and heart of pigs and also in proliferating porcine myoblasts. Overexpression of miR (zeige MYLIP Antikörper)-27a in porcine myoblasts promoted cell proliferation by reducing the expression of myostatin.
MSTN g.435G>A and g.447A>G affected carcass traits in pigs
The genotypes of MSTN g.435G > A and g.447A > G SNPs in Duroc pigs were studied. The 435GG/447AA (zeige COL16A1 Antikörper) individually had significantly higher average daily gain, body weight at 70 d and 150 d , and a lower age at 110 kg than 435AA/447GG individuals.
Porcine MSTN could be upregulated by isobutyl-1-methylxanthine , MyoD (zeige MYOD1 Antikörper), and PPARgamma (zeige PPARG Antikörper) but downregulated by C/EBPalpha (zeige CEBPA Antikörper) and C/EBPbeta (zeige CEBPB Antikörper).
a vital enhancer region was identified between nucleotides -218 and -137 in promoter region of porcine myostatin
It was concluded that myostatin is a factor broadly expressed in the internal organs and muscle tissues of pigs.
GH/HpaII locus as candidate marker for body weight in cattle rather than MSTN/DraI.
Data indicate that the the promoter trap vector PIII-myostatin could knock out the bovine myostatin gene.
The effects of myostatin and myogenic factor 5 (zeige MYF5 Antikörper) polymorphisms on growth and muscle traits of Marchigiana breed were assessed.
we demonstrate zygote injection of TALEN mRNA can also produce gene-edited cattle and sheep. In both species we have targeted the myostatin (MSTN) gene.
proof-of-concept study is the first to produce MSTN mutations in cattle, and may allow the development of genetically modified strains of double-muscled cattle.
Mutations in the leader peptide of the bovine myostatin gene effectively promote the proliferation of bovine fibroblast cells.
there were 18 SNPs identified in the Qinchuan cattle promoter region compared with those of other cattle compared to the Red Angus cattle myostatin promoter region.
A 3-way interaction of myostatin genotype (MG), season, and trigonometric function periodicities of 24 h and 12 h indicate that a genotype x environment interaction exists for MG.
These results show for the first time that myostatin regulates the differential expression of chemokines in skeletal muscle cells.
bovine myostatin is a specific target of miR (zeige MYLIP Antikörper)-27b and that miRNAs contribute to explain additive phenotypic hypertrophy in Piedmontese cattle selected for the MSTN gene mutation
MSTN knockdown caused an upregulation (p < 0.05) of MyoD (zeige MYOD1 Antikörper) and downregulation (p < 0.01) of MYf5 (zeige MYF5 Antikörper) and FST (zeige FST Antikörper) expression. Moreover, we report up to approximately four fold (p < 0.001) enhanced proliferation in myoblasts after four days of culture. The anti-MSTN shRNA demonstrated in the present study could be used for the production of transgenic goats to increase the muscle mass.
The reduced expression of myostatin gene was achieved and measured in clonal fibroblast cells by real-time PCR.
This study also suggests the importance of siRNA-mediated knockdown of MSTN as a potential alternative to increase muscle mass and meat production.
A study of the MSTN 5' upstream region and investigation of 5'UTR (zeige UTS2R Antikörper) TTTTA deletion was carried out in seven different Indian goat breeds. An 1181 bp fragment of 5' upstream region of MSTN gene was PCR amplified, cloned, and sequenced.
myostatin plays a negative role in regulating the expression of adipogenesis related genes in goat fetal fibroblasts.
Polymorphisms of myostatin gene as markers associated with growth in Boer goats.
identified several mitochondrial phenotypes associated with MSTN genotype in untrained Thoroughbred horses and in addition, our findings suggest that nutritional supplementation with CoQ may aid to restore coenzyme Q activity in TT/NN horses
The effect of an Equine Repetitive Element 1 insertion in the promoter of the myostatin gene, which is involved in muscle development, was also investigated.
Myostatin mRNA but not protein was increased in skeletal muscle of obese compared with lean animals. Myostatin mRNA was increased in crest fat of obese animals and protein was undetectable. Serum myostatin was higher in obese than lean animals.
The tissue-specific presence of myostatin, the moystatin receptor (activin receptor IIB (zeige ACVR2B Antikörper), ActRIIB (zeige ACVR2B Antikörper)), follistatin (zeige FST Antikörper) and perilipin (zeige PLIN1 Antikörper), genes and proteins across a range of equine tissues, were examined.
The candidate for racing performance genomic region contained eight genes annotated by ENSEMBL, including the myostatin gene (MSTN).
Polymorphisms of the MSTN promoter region in 5 horse breeds in Poland are reported.
significant association observed between genotype and mRNA abundance for untrained horses with the C/C cohort having highest MSTN mRNA levels,T/T group lowest levels and C/T group intermediate levels; following training there was significant decrease in MSTN mRNA which was most apparent for the C/C cohort
Exon 2 of the MSTN gene, which encodes part of the TGF-beta (zeige TGFB1 Antikörper) pro-peptide, was sequenced in 332 horses of 20 different breeds and compared with the horse MSTN gene sequence deposited in GenBank. The sequences obtained revealed the presence of 11 haplotypes represented by 10 variable nucleotide mutations, eight of them corresponding to amino acid sequence changes.
Variation at the MSTN gene influences speed in Thoroughbred horses.
This study demonstrates that the g.66493737C>T single nucleotide polymorphism in MSTN provides the most powerful genetic marker for prediction of race distance aptitude in Thoroughbreds.
Study successfully generated MSTN KO rabbits using CRISPR/Cas9 system with high efficiency. The rabbit showed typical phenotype of double muscle with hyperplasia or hypertrophy of muscle fiber.
Alignment of sequence data with the GenBank sequence of the rabbit MSTN gene identified three single nucleotide polymorphisms (SNPs). Significant linkage was found between the novel SNP c.373+234G>A and nine carcass composition traits.
These results suggest that the mutations in the upstream regulatory region of the MSTN gene are beneficial to the rabbit soma development, and the mutations can be used as molecular markers for the selection of the meat quality of rabbits.
Studied and compared mRNA levels of myostatin (MSTN), myogenin (MyoG (zeige MYOG Antikörper)), and myosin heavy chain (MyHC (zeige MYH13 Antikörper)) in skeletal muscles of two rabbit breeds with different body sizes and growth rates.
indicated that MSTN is not an important source of variability for performance traits, at least in the rabbit population
The protein encoded by this gene is a member of the bone morphogenetic protein (BMP) family and the TGF-beta superfamily. This group of proteins is characterized by a polybasic proteolytic processing site which is cleaved to produce a mature protein containing seven conserved cysteine residues. The members of this family are regulators of cell growth and differentiation in both embryonic and adult tissues. This gene is thought to encode a secreted protein which negatively regulates skeletal muscle growth.
Growth/differentiation factor 8
, growth/differentiation factor-8
, growth differentiation factor 8
, growth/differentiation factor 8