Myosin Heavy Chain 7, Cardiac Muscle, beta (MYH7) ELISA Kits

Muscle myosin is a hexameric protein containing 2 heavy chain subunits, 2 alkali light chain subunits, and 2 regulatory light chain subunits. Zusätzlich bieten wir Ihnen Myosin Heavy Chain 7, Cardiac Muscle, beta Antikörper (70) und Myosin Heavy Chain 7, Cardiac Muscle, beta Proteine (8) und viele weitere Produktgruppen zu diesem Protein an.

list all ELISA KIts Gen GeneID UniProt
MYH7 4625 P12883
MYH7 29557 P02564
MYH7 140781 Q91Z83
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Top Myosin Heavy Chain 7, Cardiac Muscle, beta ELISA Kits auf

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Katalog Nr. Reaktivität Sensitivität Bereich Bilder Menge Anbieter Lieferzeit Preis Details
Human 0.056 ng/mL 0.15 ng/mL - 10 ng/mL 96 Tests Anmelden zum Anzeigen 13 bis 16 Tage
Ratte 52 pg/mL 125.00 pg/mL - 8000 pg/mL 96 Tests Anmelden zum Anzeigen 13 bis 16 Tage
Maus 12.4 pg/mL 31.25 pg/mL - 2000 pg/mL 96 Tests Anmelden zum Anzeigen 13 bis 16 Tage
Rind (Kuh)
  96 Tests Anmelden zum Anzeigen 2 bis 3 Tage
  96 Tests Anmelden zum Anzeigen 15 bis 18 Tage
  96 Tests Anmelden zum Anzeigen 15 bis 18 Tage

Weitere ELISA Kits für Myosin Heavy Chain 7, Cardiac Muscle, beta Interaktionspartner

Human Myosin Heavy Chain 7, Cardiac Muscle, beta (MYH7) Interaktionspartner

  1. Asp554Tyr mutation of the MYH7 gene are associated with the hypertrophic cardiomyopathy in the Chinese pedigree.

  2. This study functionally characterized the motor domains of five Dilated cardiomyopathy - causing mutations in human beta-cardiac myosin, MYH7. Kinetic analyses of the individual events in the ATPase cycle revealed that each mutation alters different steps in this cycle.

  3. Of the 52 hypertrophic cardiomyopathy patients 12 (23.1%) had MYH7 variants.

  4. A family that demonstrates the diverse HCM phenotypes associated with a single MYH7 mutation.

  5. Mutation in MYH7 was identified as Restrictive Cardiomyopathy - causing mutation.

  6. MYH7-V878A and CACNA1C-A1594V mutations were detected in a Chinese Family with Hypertrophic Cardiomyopathy. Among those with only the MYH7-V878A mutation, subject III-7 showed abnormal ECG recordings, asymmetric septal hypertrophy, and myocardial fibrosis, and subjects II-13 and III-15 showed some abnormal repolarization, borderline LV wall thickness, and normal cardiac magnetic resonance (CMR) findings.

  7. Asn391Thr mutation of MYH7 is a malignant mutation for hypertrophic cardiomyopathy and that mutation carriers should get effective treatment to prevent sudden death.

  8. MYBPC3 mutation carriers had a high frequency of ventricular arrhythmia and syncope. An absence of family history of sudden death (SD) and past history of syncope are useful prognostic factors in patients with hypertrophic cardiomyopathy. MYH7 and MYBPC3 mutations did not significantly influence prognosis compared to non-carriers. The patients with the MYBPC3 mutation should be closely followed for the possibility of SD.

  9. Five of the 19 patients (26.3%) had either a pathogenic variant or a likely pathogenic variant in MYBPC3 (n=1), MYH7 (n=1), RYR2 (n=2), or TNNT2 (n=1). All five variants were missense variants that have been reported previously in patients with channelopathies or cardiomyopathies

  10. Double MYH7 CTTNA3 heterozygotes showed a variable clinical expression of arrhythmogenic cardiomyopathy and hypertrophic cardiomyopathy. One carrier of double mutations in CTTNA3 and MYH7 genes did not fulfill the current diagnostic criteria for cardiomyopathy.

  11. Data provide evidence that MYH7 mutations contributed to 24.4% MYBPC3 mutations of hypertrophic cardiomyopathy (HCM) cases, that MYBPC3 constitute the preeminent cause of HCM and that both mutations are phenotypically indistinguishable.

  12. Digenic inheritance of two novel variants in TNNT2 and MYH7 is associated with a severe form of dilated cardiomyopathy.

  13. MYH7-V878A is a hot spot among ethnic Han Chinese with a high penetrance.

  14. Unlike previous Hypertrophic cardiomyopathy (HCM)mutations studied at the molecular level using human beta-cardiac myosin, early-onset HCM mutations lead to significantly larger changes in the fundamental biomechanical parameters and show clear hyper-contractility

  15. Gly716Arg allele carriers have an extremely poor prognosis, and the females seem to have a longer life expectancy than males. To the best of our knowledge, this study is the largest cohort study of the Gly716Arg allele.

  16. We investigated a male with familial familial hypertrophic cardiomyopathy with restrictive physiology and we identified a novel missense mutation p.Arg719Leu of beta-myosin heavy chain (MYH7) gene

  17. ur results suggest that the basis for the pathogenic effect of the R1845W and H1901L mutations of the MYH7 are primarily structural rather than functional. Further analyses are needed to identify the primary trigger for the histological changes seen in muscle biopsies of patients with L1793P and E1883K mutations.

  18. The authors demonstrate myosin tail (S2)-dependent functional regulation of actin-activated human beta-cardiac myosin ATPase. In addition, they show that both S2 and MyBP-C bind to S1 and that phosphorylation of either S1 or MyBP-C weakens these interactions.

  19. Our study supports that mutations in MYH7 and MYBPC3 should be the first focus of moleculargenetic analysis in HCM, and that mutations in TNNT2 have a low prevalence in Brazilian population. All mutations detected were missense mutations, whereas two mutations in MYH7 had not been described before.

  20. Study shows lack of phenotypic differences between MYH7- and MYBPC3-associated hypertrophic cardiomyopathy when assessed by cardiac magnetic resonance imaging.

Cow (Bovine) Myosin Heavy Chain 7, Cardiac Muscle, beta (MYH7) Interaktionspartner

  1. Tm affects the conformation of actin so as to increase the area of hydrophobic interaction between actin and myosin molecules

Pig (Porcine) Myosin Heavy Chain 7, Cardiac Muscle, beta (MYH7) Interaktionspartner

  1. Akirin2 siRNA abolished arginine-induced upregulation of MyHC I.

  2. Myosin regulatory light chain phosphorylation enhances cardiac beta-myosin in vitro motility under load.

  3. Mutation analysis of MYH7 gene revealed an in-frame insertion within exon 30 of MYH7 which was perfectly associated with the disease phenotype and confirmed the dominant inheritance.

Mouse (Murine) Myosin Heavy Chain 7, Cardiac Muscle, beta (MYH7) Interaktionspartner

  1. These data demonstrate functional cooperation between Sox6 and Nfix in regulating MyHC-I expression during prenatal muscle development.[MyHC-1]

  2. Male/female Myh7 mutant mice display sex dimorphic crossbridge kinetics accompanied by sex- and hypertrophic cardiomyopathy-dependent cardiac remodeling at the morphometric, histological, and cellular level.

  3. The promoter regions of the SERCA-2A and beta-MHC genes, Atp2a2 and Myh7, respectively in murine hearts after one or eight weeks of pressure overload induced by transverse aortic constriction, were evaluated.

  4. Foxo1 has important roles in promoting diabetic cardiomyopathy and controls beta-MHC expression in the development of cardiac dysfunction.

  5. Transgenic mouse alpha- and beta-cardiac myosins containing the R403Q mutation show isoform-dependent transient kinetic differences.

  6. Cooperative/allosteric effects on actomyosin crossbridge recruitment dynamics are increased by beta-MHC.

  7. Reexpression of bMHC is associated at the bMHC promoter with increased H3ac but not H3K4me3.

  8. Metabolic and myosin isoform gene expression switch in sepsis-induced myocardial depression is inducible nitric oxide synthase-dependent.

  9. residues situated within or close to the actin-binding interface of the myosin head influence actin binding and thereby modulate actin-activated ATPase activity

  10. Simultaneous defects in MHC7 & TnI accelerate onset & progression of familial hypertrophic cardiomyopathy. Compared with single-mutant models, double-mutant mice develop severe disease & premature death, progressing directly to a dilated phenotype.

  11. the functional consequences of the mutation are fundamentally changed depending upon the context of the cardiac MHC isoform.

Myosin Heavy Chain 7, Cardiac Muscle, beta (MYH7) Antigen-Profil

Beschreibung des Gens

Muscle myosin is a hexameric protein containing 2 heavy chain subunits, 2 alkali light chain subunits, and 2 regulatory light chain subunits. This gene encodes the beta (or slow) heavy chain subunit of cardiac myosin. It is expressed predominantly in normal human ventricle. It is also expressed in skeletal muscle tissues rich in slow-twitch type I muscle fibers. Changes in the relative abundance of this protein and the alpha (or fast) heavy subunit of cardiac myosin correlate with the contractile velocity of cardiac muscle. Its expression is also altered during thyroid hormone depletion and hemodynamic overloading. Mutations in this gene are associated with familial hypertrophic cardiomyopathy, myosin storage myopathy, dilated cardiomyopathy, and Laing early-onset distal myopathy.

Genbezeichner und Symbole assoziert mit MYH7

  • myosin heavy chain 7 (MYH7) Antikörper
  • myosin heavy chain 7 (Myh7) Antikörper
  • myosin, heavy chain 7, cardiac muscle, beta (MYH7) Antikörper
  • myosin, heavy polypeptide 7, cardiac muscle, beta (Myh7) Antikörper
  • AMHC1 Antikörper
  • B-MHC Antikörper
  • beta-MHC Antikörper
  • CMD1S Antikörper
  • CMH1 Antikörper
  • MPD1 Antikörper
  • Myhc-b Antikörper
  • MyHC-I Antikörper
  • Myhcb Antikörper
  • myosin Antikörper
  • myosin-7 Antikörper
  • SPMD Antikörper
  • SPMM Antikörper

Bezeichner auf Proteinebene für MYH7

beta-myosin heavy chain , myHC-beta , myhc-slow , myopathy, distal 1 , myosin heavy chain (AA 1-96) , myosin heavy chain 7 , myosin heavy chain slow isoform , myosin heavy chain, cardiac muscle beta isoform , myosin, heavy polypeptide 7, cardiac muscle, beta , myosin-7 , rhabdomyosarcoma antigen MU-RMS-40.7A , beta myosin heavy chain , myHC-slow , myosin heavy chain polypeptide 7 cardiac muscle fetal , myosin heavy chain, cardiac muscle, fetal , myosin heavy chain, polypeptide 7 , type slow/beta myosin heavy chain , cardiac muscle , chick atrial myosin heavy chain , heavy polypeptide 7 , myosin heavy chain , MYH-beta/slow , cardiac myosin heavy chain beta , beta cardiac myosin heavy chain , myosin 7 , myosin heavy chain slow type 1 (beta cardiac) , beta-myosin-heavy-chain , myosin beta heavy chain

4625 Homo sapiens
29557 Rattus norvegicus
282714 Bos taurus
395350 Gallus gallus
396860 Sus scrofa
140781 Mus musculus
791234 Equus caballus
403807 Canis lupus familiaris
100101566 Oryctolagus cuniculus
100727138 Cavia porcellus
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