Myosin Binding Protein C, Slow Type (MYBPC1) ELISA Kits

Zebrafish Myosin Binding Protein C, Slow Type (MYBPC1) Interaktionspartner

1. MYBPC1 mutations impair skeletal muscle function in zebrafish models of arthrogryposis.

Cow (Bovine) Myosin Binding Protein C, Slow Type (MYBPC1) Interaktionspartner

1. Increase of the MYBPC1 expression level might lead to high growth performance in cattle.

2. The NC_007303.5:g.70014208A>G SNP is associated with marbling in Japanese Black beef cattle, with the G allele resulting in high levels of marbling. This SNP might have an impact on MYBPC1 expression and marbling by affecting MYBPC1 promoter activity.

Rabbit Myosin Binding Protein C, Slow Type (MYBPC1) Interaktionspartner

1. the in vitro motility assay with full length slow skeletal MyBPC slowed down the actin filament sliding over myosin thick filaments. This study demonstrates that skeletal MyBPC both enhanced the mechanical stability of the S2 coiled coil and reduced the sliding velocity of actin filaments over polymerized myosin filaments.

Human Myosin Binding Protein C, Slow Type (MYBPC1) Interaktionspartner

1. A novel milder MYBPC1 homozygous phenotype causes arthrogryposis multiplex congenita in a consanguineous Israeli Druze pedigree.

2. Ca(2+) modulates the interaction of cMyBP-C with the thin filament in the sarcomere.

3. Two novel mutations in myosin binding protein C slow causing distal arthrogryposis type 2 were both found to occur in the C2 immunoglobulin domain, which constitutes part of the binding site for the S2 subfragment of myosin.

4. Mutations in the MYH7 gene, rather than in the MYBPC3 gene, were also related to a worse prognosis. This is the first work characterizing HC molecular epidemiology in the Brazilian population for the 3 most important genes.

5. Autosomal recessive lethal congenital contractural syndrome type 4 (LCCS4) caused by a mutation in MYBPC1

6. Significant molecule MYBPC1 phosphoprotein network from 12 frontal cortex of HIV encephalitis (HIVE) control patients and 16 HIVE, was identified and constructed.

7. MyBPC1 acts as an adaptor to connect the ATP consumer (myosin) and the regenerator (muscle type creatine kinase) for efficient energy metabolism and homoeostasis.

8. These findings reveal that the MYBPC1 is a novel gene responsible for DA1, though the mechanism of disease may differ from how some cardiac MYBPC3 mutations cause hypertrophic cardiomyopathy.

9. Screening patients with dilated cardiomyopathy, as well as hypertrophic cardiomyopathy, for this mutation is of signifiant importance with this mutation diagnosing dilated cardiomyopathy.

10. The present study demonstrates slow skeletal muscle type C-protein in moderate amount in right atrium and interatrial septum of adult human, rabbit, rat and bovine hearts using both immunocytochemical and immunoblotting procedures.

11. to determine whether HCM mutations in beta myosin heavy chain located within the light meromyosin portion alter the binding of cMyBP-C, and to define the precise region of this binding.

Mouse (Murine) Myosin Binding Protein C, Slow Type (MYBPC1) Interaktionspartner

1. Data show that the NH2 and COOH termini of myosin binding protein C slow type (sMyBP-C) have distinct functions, which are regulated by differential splicing, and are compromized by the presence of missense point mutations linked to muscle disease.