anti-Myelin Basic Protein (MBP) Antikörper

Human Myelin Basic Protein (MBP) Interaktionspartner

1. results do not support an association of the analysed SLC6A3 and MBP gene polymorphisms with PTSD in war traumatized individuals; there is a possibility for a correlation of the T allele rs12458282 within the MBP gene with higher CAPS scores in lifetime PTSD patients which would need to be tested in a sample providing more statistical power

2. down-regulated in cord blood by prenatal smoking

3. the interaction between the HLA-DRB1*1501 allele and MBP gene may be considered as a predisposing factor in the development and pathogenesis of multiple sclerosis in the case of gene-gene interaction

4. PAPP-A and ProMBP are associated with increased risk of death in heart failure patients.

5. Studied potential use of myelin basic protein (MBP) as a biomarker in CSF of brain cancer patients. Results suggest that the presence of MBP in CSF may be considered as an indicator of the brain tumor development.

6. t-PA binds to Lys91 in the MBP NH2-terminal region and PLG binds to Lys122 in the MBP COOH-terminal region. This proximity promotes the activation of PLG by t-PA.

7. Specific sites of post-translational modifications in multiple sclerosis patients are localized in two zones of MBP suggests that these regions may be involved in antigen recognition by the body's immune surveillance machinery

8. Results provide novel insights into the role of genetic variation within the MBP gene predicting multiple sclerosis clinical course, both directly and by interaction with known environmental MS risk factors

9. Pathway analysis demonstrated that the majority of the differentially expressed genes (23.3%) were involved in cytokinecytokine receptor interaction. Subsequent to GolliMBP knockdown, the mechanisms that changed the biological characteristics of Jurkat cells were complex, involving numerous types of functional proteins, and metabolic and signaling pathway

10. Deimination of myelin basic protein (MBP) by peptidylarginine deiminase (PAD) prevents its binding to the proteasome and decelerates its degradation by the proteasome in mammalian cells. Potential anticancer drug tetrazole analogue of chloramidine 2, at concentrations greater than 1 microM inhibits the enzymatic activity of PAD in vitro.

11. This study observed a significantly increased myelin basic protein (MBP) and nuclear distribution protein nudE-like 1 (NDEL1) mRNA levels in FEP patients compared with controls.

12. myelin basic protein has a role in activating CD4+ and CD8+ T lymphocytes in multiple sclerosis

13. B cells from relapsing-remitting multiple sclerosis patients produce TNFa and IL6, and present MBP85-99 peptide

14. IL-17- and IL-22-secreting myelin specific CD4(+) T cells resistant to corticoids are associated with radiological activity of multiple sclerosis in early stages of the disease, mainly among Afrodescendant patients who, normally, have worse prognosis.

15. Studies indicate that all myelin basic protein (MBP) isoforms are intrinsically disordered proteins (IDPs) that interact via molecular recognition fragments (MoRFs), which thereby undergo local disorder-to-order transitions.

16. Reduced myelin basic protein-induced CD4+ T-cell autoreactivity in interferon-beta-treated multiple sclerosis patients may be mediated by monocyte-derived interleukin-10

17. Negatively charged actin and calmodulin (CaM), as well as basic histone H1.3, inhibit MBP hydrolysis by competing with the proteasome and MBP, respectively, for binding their counterpart.

18. data reveal the first case of a pathophysiologically important autoantigen as a ubiquitin-independent substrate of the 26S proteasome.

19. Single nucleotide polymorphisms on genetic loci SOD2, MBP and C8orf42were not found significantly associated with advanced age-related macular degeneration in a Chinese cohort

20. In autistic children with allergic manifestations there were increased serum levels of MBP (and MAG) compared to those without allergies.

Mouse (Murine) Myelin Basic Protein (MBP) Interaktionspartner

1. Results support the formation of an amorphous protein phase of MBP between two membrane bilayers and provide a molecular model for major dense line formation during myelination, which is of importance when understanding myelin assembly and demyelinating conditions.

2. findings suggest that the acetylation and methylation of lysine on MBP are post-translational modifications associated with the neurological disability produced by EAE.

3. golli-KO mice display abnormal behavior including deficits in episodic memory and reduced anxiety.

4. The Mbp(+/-) mice exhibited defects of sensorimotor gating, as evidenced by reduced prepulse-inhibition, and a late-onset catatonia phenotype.

5. The present study provides evidence for a novel L1-mediated function of MBP in the developing spinal cord and in the injured adult mammalian nervous system that leads to enhanced recovery after acute trauma.

6. myelin basic protein (MBP) is inhibitory to both primitive neural stem cells and definitive neural stem cells derived colony formation.

7. CNP directly associates with and organizes the actin cytoskeleton, thereby providing an intracellular strut that counteracts membrane compaction by myelin basic protein (MBP).

8. to further characterize the mechanism regulating mbp transcription, study defined M3 structure/function relationships; multiple M3 regulatory element combinations were found to drive expression in oligodendrocytes and Schwann cells with a minimal 129 bp sequence conferring expression in oligodendrocytes throughout myelin elaboration, maintenance and repair

9. Results show the expression of sncRNA715 in Schwann cells and its inverse correlation with Mbp mRNA in cultured cells and the sciatic nerve. Its inhibitory effect on MBP was confirmed in differentiating primary Schwann cells.

10. Results suggest that GAL is a regulator of myelination, as demonstrated by MBP synthesis, and may be one of the myelination promoters

11. Data indicate that 18.5 kDa myelin basic protein (MBP) segment upstream of the primary SH3-ligand is involved in interaction.

12. Data suggest that prenatal alterations in expression of various fetal brain proteins (including up-regulation of Mbp) are associated with aberrant behavioral characteristics of transgenic mice that model autism-like behavior.

13. Data suggest that hybrid protein composed of two different Myelin basic protein (MBP) isoforms (TandeMBP) might become a tool for in vitro assays to analyse various protein kinase activities.

14. Data indicate a role for myelin basic protein (MBP) isoforms in protein-protein interactions during membrane and cytoskeletal extension and remodeling in oligodendrocytes (OLGs).

15. Disappearance of 21.5 pMBP corresponded to demyelination and its reappearance corresponded to prevention of demyelination.

16. Golli-BG21 enhanced SCP1/GIP phosphatase activity, whereas PKCalpha-phosphorylated BG21 inhibited its activity, suggesting a potential role of BG21 as a molecular switch ("quick-brake mechanism") on SCP1/GIP.

17. Myelin basic protein cleaves cell adhesion molecule L1 and promotes neuritogenesis and cell survival.

18. MBP expression in cultured Fmr1 KO oligodendrocytes is similar to wild type, and expression of MBP in brain homogenates of the Fmr1 KO mouse to be similar to wild type.

19. myelin basic protein drives myelin biogenesis using weak forces arising from its inherent capacity to phase separate.

20. Myelin basic protein-21.5 kDa in the nucleus promotes oligodendrocyte proliferation, while melin basic protein-18.5-kDa in plasma membrane does not.

Zebrafish Myelin Basic Protein (MBP) Interaktionspartner

1. Dynein/dynactin is necessary for anterograde transport of Mbp mRNA in oligodendrocytes.

Pig (Porcine) Myelin Basic Protein (MBP) Interaktionspartner

1. Concentrations of MBP did not increase after injury in all age groups

2. results provide a detailed picture of the MBP-CaM interaction, including a 3D model of the complex between full-length proteins

3. MBP-hydrolyzing antibodies may play an important role in multiple sclerosis pathogenesis

Cow (Bovine) Myelin Basic Protein (MBP) Interaktionspartner

1. Deimination of myelin basic protein (MBP) by peptidylarginine deiminase (PAD) prevents its binding to the proteasome and decelerates its degradation by the proteasome in mammalian cells. Potential anticancer drug tetrazole analogue of chloramidine 2, at concentrations greater than 1 microM inhibits the enzymatic activity of PAD in vitro.

2. Data suggest that hybrid protein composed of two different Myelin basic protein (MBP) isoforms (TandeMBP) might become a tool for in vitro assays to analyse various protein kinase activities.

3. trehalose completely avoid autocatalytic cleavage properties of MBP up to 4 days of incubation at 37 degrees C and pH 7.4.

4. formation of an imine between inflammatory-derived aldehydes can lead to structural changes in MBP and a decrease in myelin stability

5. results provide a detailed picture of the MBP-CaM interaction, including a 3D model of the complex between full-length proteins

6. MBP can induce a dihydrocholesterol-dependent segregation of phases that can be further regulated by the electrolyte concentration in the subphase and the composition (type and proportion) of non-sterol lipids.

7. Bovine MBP priming reduces expression of Foxp3 via nitric oxide in inducible nitric oxide synthase-deficient mouse T cells.

8. investigation of bovine myelin basic protein binding to triphosphoinositide

9. There is a developmental regulation of posttranslationally modified forms of myelin basic protein into specific membrane microdomains.

10. These results suggest that phospholipids and sulfatide and heparin may function as effective stimulators for autophosphorylation of GSK-3beta and for the GSK-3beta-mediated high phosphorylation of SH-binding proteins, including MBP and tau protein.

11. Myelin basic protein (MBP), a major autoantigen in multiple sclerosis, is a potent and specific ligand for integrin alphaMbeta2 expressed mainly on phagocytic cells.