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May play a role in compacting or stabilizing the myelin sheath, possibly by binding the negatively charged acidic phospholipids of the cytoplasmic membrane (By similarity)..
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Mutation in MOBP gene is associated with amyotrophic lateral sclerosis.
The rs1768208 risk polymorphism in MOBP has prognostic value in behavioral-variant frontotemporal dementia.
Genotypes at MOBP and EIF2AK3 (zeige EIF2AK3 ELISA Kits) confer risk predominantly in APOE (zeige APOE ELISA Kits) epsilon4-positive subjects, with indications of an interaction between APOE (zeige APOE ELISA Kits) and MOBP or EIF2AK3 (zeige EIF2AK3 ELISA Kits) on Alzheimer's disease risk.
Decreased expression of a number of myelin-related genes, including myelin basic protein (MBP (zeige MBP ELISA Kits)), proteolipid protein (PLP (zeige PLP1 ELISA Kits)), and myelin-associated oligodendrocyte basic protein (MOBP) was noted in nucleus accumbens of cocaine abusers
MOBP mRNA levels were increased in the DLPFC white matter in patients with a history of substance abuse.
MOBP synthesis is stimulated by Fyn (zeige FYN ELISA Kits) activity.
Mobp is associated with the alcohol-preference genotype in the context of alcohol-preferring, compared to alcohol-avoiding mouse strains.
MOBP-deficient mice develop normally, generate intact compact CNS myelin, and demonstrate no obvious clinical phenotype; absence of MOBP is not simply compensated for by increased expression of the "classic" myelin basic protein (MBP (zeige MBP ELISA Kits)).
Although the Mobp155 and Mobp170 isoforms encode a common predicted C-terminus they have different expression profiles and their products are targeted to mitochondria and the nucleus, respectively, in transiently transfected Cos7 cells.
May play a role in compacting or stabilizing the myelin sheath, possibly by binding the negatively charged acidic phospholipids of the cytoplasmic membrane (By similarity).
Myelin-associated/Oligodendrocytic Basic Protein-81
, myelin-associated oligodendrocytic basic protein
, myelin-associated oligodendrocyte basic protein