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The protein encoded by MSC is a transcriptional repressor capable of binding an E-box element either as a homodimer or as a heterodimer with E2A in vitro.
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this study shows that musculin inhibits human T-helper 17 cell response to interleukin 2 (zeige IL2 ELISA Kits) by controlling STAT5B (zeige STAT5B ELISA Kits) activity
results demonstrate that ABF-1 facilitates formation of memory B cells but prevents plasma cell differentiation.
role in repressing lymphotoxin alpha
ABF-1 is frequently silenced by promoter methylation in follicular lymphoma, diffuse large B-cell lymphoma and Burkitt's lymphoma.
this study shows that MSC-deficient TGFb (zeige TGFB1 ELISA Kits)-induced Treg cells are unable to suppress Th2 cell responses, and that MSC-deficient mice spontaneously develop gut (zeige GUSB ELISA Kits) and lung inflammation with age
MyoR modulates cardiac conduction by repressing Gata4 (zeige GATA4 ELISA Kits).
MyoR is a transcription factor selectively up-regulated in CD4 (zeige CD4 ELISA Kits) T cells during Tfh cell differentiation
Basic helix-loop-helix transcriptional factor MyoR regulates BMP-7 (zeige BMP7 ELISA Kits) in acute kidney injury.
Data show that correct levels of expression of Myf5 (zeige MYF5 ELISA Kits) and MyoD (zeige MYOD1 ELISA Kits) during mouse craniofacial development result from activation by musculin and TCF21 (zeige TCF21 ELISA Kits) through direct binding to specific enhancers.
a feed-forward loop where MyoD (zeige MYOD1 ELISA Kits) indirectly down-regulates MyoR via miR (zeige MLXIP ELISA Kits)-378
findings identify MyoR and capsulin (zeige TCF21 ELISA Kits) as unique transcription factors for the development of specific head muscles
MyoR may serve as a repressor of embryonal endoderm differentiation.
Our results suggest that musculin/MyoR may play important roles not only in developmental processes but also in regenerative processes in adult tissue.
The protein encoded by this gene is a transcriptional repressor capable of binding an E-box element either as a homodimer or as a heterodimer with E2A in vitro. The encoded protein also forms heterodimers with E2A proteins in vivo. This protein is capable of inhibiting the transactivation capability of E47, an E2A protein, in mammalian cells. This gene is a downstream target of the B-cell receptor signal transduction pathway.
, musculin (activated B-cell factor-1)
, activated B-cell factor 1, homolog of mouse musculin
, activated B-cell factor-1
, class A basic helix-loop-helix protein 22
, myogenic repressor