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activity; localization, and function is regulated by the C-terminal tail. Zusätzlich bieten wir Ihnen Mitogen-Activated Protein Kinase 15 Kits (11) und Mitogen-Activated Protein Kinase 15 Proteine (8) und viele weitere Produktgruppen zu diesem Protein an.
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Human Polyclonal MAPK15 Primary Antibody für IHC (p), WB - ABIN391796
Groehler, Lannigan: A chromatin-bound kinase, ERK8, protects genomic integrity by inhibiting HDM2-mediated degradation of the DNA clamp PCNA. in The Journal of cell biology 2010
CapZIP (zeige RCSD1 Antikörper), which has been shown to regulate ciliogenesis, is an ERK7 substrate, and that Dishevelled (zeige DVL2 Antikörper), which has also been shown to regulate ciliogenesis, facilitates ERK7 phosphorylation of CapZIP (zeige RCSD1 Antikörper) through binding to both ERK7 and CapZIP (zeige RCSD1 Antikörper).
Our results describe a primary cilia-related role for this poorly studied member of the MAPK (zeige MAPK1 Antikörper) family in vivo, and indicate a broad requirement for MAPK15 in the formation of multiple ciliary classes across species.
High MAPK15 expression is associated with male germ cell tumors.
In HeLa cells, phosphorylation of HuR (zeige ELAVL1 Antikörper) by ERK8 prevents it from binding to PDCD4 (zeige PDCD4 Antikörper) mRNA and allows miR (zeige MLXIP Antikörper)-21-mediated degradation of PDCD4 (zeige PDCD4 Antikörper).
depletion of endogenous MAPK15 expression inhibited BCR (zeige BCR Antikörper)-ABL1 (zeige ABL1 Antikörper)-dependent cell proliferation, in vitro
The present study suggests that MAPK15 overexpression may contribute to the malignant transformation of gastric mucosa by prolonging the stability of c-Jun (zeige JUN Antikörper).
ERK8 appears as a constitutive brake on N-Acetylgalactosaminyltransferase (zeige B4GALNT2 Antikörper) relocalisation, and the loss of its expression could drive cancer aggressivity through increased cell motility.
Data suggest that the model coulb be a tool for the development of specific ERK8 kinase inhibitors.
ATG8 (zeige GABARAPL2 Antikörper)-like proteins (MAP1LC3B (zeige MAP1LC3B Antikörper), GABARAP (zeige GABARAP Antikörper) and GABARAPL1 (zeige GABARAPL1 Antikörper)) are novel interactors of MAPK15/ERK8, a MAP kinase (zeige MAPK1 Antikörper) involved in cell proliferation and transformation.
a novel function for ERK8 as a bona fide ERRalpha (zeige ESRRA Antikörper) corepressor, involved in control of its cellular localization by nuclear exclusion, and suggest a key role for this MAP kinase (zeige MAPK1 Antikörper) in the regulation of the biological activities of this nuclear receptor.
Data show that ERK8 prevents HDM2-mediated PCNA (zeige PCNA Antikörper) destruction by inhibiting the association of PCNA (zeige PCNA Antikörper) with HDM2, and implicate ERK8 in the regulation of genomic stability.
Taken together, our results suggest that ERK8 plays an important role in spindle organization during mouse oocyte meiotic maturation and early embryo cleavage.
Extracellular signal-regulated kinase 8-mediated c-Jun (zeige JUN Antikörper) phosphorylation increases tumorigenesis of human colon cancer
Erk8 has a role as a novel effector of RET (zeige RET Antikörper)/PTC3 (zeige NCOA4 Antikörper) and, therefore, RET (zeige RET Antikörper) biological functions
activity\; localization, and function is regulated by the C-terminal tail
mitogen-activated protein kinase 15
, extracellular signal-regulated kinase 7
, MAP kinase 15
, MAPK 15
, extracellular regulated kinase 8 delta
, extracellular signal regulated kinase 8
, extracellular signal-regulated kinase 8