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activity; localization, and function is regulated by the C-terminal tail. Zusätzlich bieten wir Ihnen Mitogen-Activated Protein Kinase 15 Kits (11) und Mitogen-Activated Protein Kinase 15 Proteine (8) und viele weitere Produktgruppen zu diesem Protein an.
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Human Polyclonal MAPK15 Primary Antibody für IHC (p), ELISA - ABIN543916
Klevernic, Stafford, Morrice, Peggie, Morton, Cohen: Characterization of the reversible phosphorylation and activation of ERK8. in The Biochemical journal 2006
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Human Polyclonal MAPK15 Primary Antibody für IHC (p), WB - ABIN391796
Groehler, Lannigan: A chromatin-bound kinase, ERK8, protects genomic integrity by inhibiting HDM2-mediated degradation of the DNA clamp PCNA. in The Journal of cell biology 2010
CapZIP, which has been shown to regulate ciliogenesis, is an ERK7 substrate, and that Dishevelled, which has also been shown to regulate ciliogenesis, facilitates ERK7 phosphorylation of CapZIP through binding to both ERK7 and CapZIP.
Our results describe a primary cilia-related role for this poorly studied member of the MAPK family in vivo, and indicate a broad requirement for MAPK15 in the formation of multiple ciliary classes across species.
High MAPK15 expression is associated with male germ cell tumors.
In HeLa cells, phosphorylation of HuR by ERK8 prevents it from binding to PDCD4 mRNA and allows miR-21-mediated degradation of PDCD4.
depletion of endogenous MAPK15 expression inhibited BCR-ABL1-dependent cell proliferation, in vitro
The present study suggests that MAPK15 overexpression may contribute to the malignant transformation of gastric mucosa by prolonging the stability of c-Jun.
ERK8 appears as a constitutive brake on N-Acetylgalactosaminyltransferase relocalisation, and the loss of its expression could drive cancer aggressivity through increased cell motility.
Data suggest that the model coulb be a tool for the development of specific ERK8 kinase inhibitors.
ATG8-like proteins (MAP1LC3B, GABARAP and GABARAPL1) are novel interactors of MAPK15/ERK8, a MAP kinase involved in cell proliferation and transformation.
a novel function for ERK8 as a bona fide ERRalpha corepressor, involved in control of its cellular localization by nuclear exclusion, and suggest a key role for this MAP kinase in the regulation of the biological activities of this nuclear receptor.
Data show that ERK8 prevents HDM2-mediated PCNA destruction by inhibiting the association of PCNA with HDM2, and implicate ERK8 in the regulation of genomic stability.
Extracellular signal-regulated kinase 8-mediated c-Jun phosphorylation increases tumorigenesis of human colon cancer
ERK8, a new member of the mitogen-activated protein kinase family.
The activity of ERK8 in transfected HEK-293 cells depends on the relative rates of ERK8 autophosphorylation and dephosphorylation by one or more members of the PPP family of protein serine/threonine phosphatases.
Erk8 has a role as a novel effector of RET/PTC3 and, therefore, RET biological functions
human ERK8 has a role as a negative regulator of human GRalpha, acting through Hic-5
Regulation of the activity and expression of DERK8 by DNA damage are reported.
Taken together, our results suggest that ERK8 plays an important role in spindle organization during mouse oocyte meiotic maturation and early embryo cleavage.
activity\; localization, and function is regulated by the C-terminal tail
mitogen-activated protein kinase 15
, extracellular signal-regulated kinase 7
, MAP kinase 15
, MAPK 15
, extracellular regulated kinase 8 delta
, extracellular signal regulated kinase 8
, extracellular signal-regulated kinase 8