Microtubule-Actin Crosslinking Factor 1 (MACF1) ELISA Kits

The protein encoded by MACF1 belongs to the plakin family of cytoskeletal linker proteins. Zusätzlich bieten wir Ihnen MACF1 Antikörper (13) und und viele weitere Produktgruppen zu diesem Protein an.

list all ELISA KIts Gen GeneID UniProt
MACF1 23499 Q9UPN3
MACF1 11426  
MACF1 362587  
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Katalog Nr. Reaktivität Sensitivität Bereich Bilder Menge Lieferzeit Preis Details
Human
  96 Tests 15 bis 18 Tage
$875.60
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  96 Tests 15 bis 18 Tage
$875.60
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Ratte
  96 Tests 15 bis 18 Tage
$875.60
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Weitere ELISA Kits für MACF1 Interaktionspartner

Zebrafish Microtubule-Actin Crosslinking Factor 1 (MACF1) Interaktionspartner

  1. We propose that Macf1a does not function via its canonical mechanism of linking two cytoskeletal systems together in dissociating the Bb. Instead our results suggest that Macf1a functions by linking one cytoskeletal system, cortical actin, to another structure, the Bb, where Macf1a is localized.

  2. Macf1 regulates the balbiani body and the polarity of oocyte.

Human Microtubule-Actin Crosslinking Factor 1 (MACF1) Interaktionspartner

  1. Three de novo variants in MACF1 have been observed in large schizophrenia cohorts.

  2. In this study, uncontrolled Diabetes mellitus (DM) had a remote impact on different components of the platelet transcriptome. Increased expression of MACF1, together with supporting predicted mRNA-miRNA interactions as well as reduced expression of RNYs in platelets, may reflect subclinical platelet activation in uncontrolled DM.

  3. MACF1 overexpression triggered a drastic increase in osteogenic gene expression, alkaline phosphatase activity, and matrix mineralization in vitro. Mouse calvarial thickness, mineral apposition rate, and osteogenic marker protein expression were significantly enhanced by local transfection. In addition, MACF1 overexpression promoted beta-catenin expression and signaling.

  4. Loss of ACF7 leads to aberrant microtubule organization, tight junction stabilization and impaired wound closure in vitro. ACF7 level is also correlated with development and progression of ulcerative colitis (UC) in patients.

  5. Study summarized the physiological role of MACF1 as well as its pathological one in various cancers. MACF1 comprises different isoforms, and is broadly expressed in brain, spinal cord, lung, kidney, heart, bone and skeletal muscles tissues. It plays a crucial role in cell proliferation, migration and cell signaling, and is also closely associated with many cancer.

  6. in mammalian intestinal epithelial cells, the spectraplakin ACF7 (also known as MACF1) specifically binds to CAMSAP3 and is required for the apical localization of CAMSAP3-decorated microtubule minus ends.

  7. MACF1b may contribute to the genetic etiology and mechanistic causation of Parkinson's disease.

  8. ACF7, a member of the spectraplakin family of cytoskeletal crosslinking proteins, interacts with Nezha (also called CAMSAP3) at the minus ends of noncentrosomal microtubules and anchors them to actin filaments.

  9. the present study represents the first investigation on the functional role of MACF1 in tumor cell biology, as well as demonstrates its potential as a unique biomarker that can be targeted synergistically with TMZ as part of a combinatorial therapeutic approach for the treatment of genetically multifarious glioblastomas

  10. Duplication in the microtubule-actin cross-linking factor 1 gene causes neuromuscular diseases.

  11. uncovered a role for ELMO in the recruitment of ACF7 to the membrane to promote microtubule capture and stability

  12. ACF7 targeting to the plasma membrane is both required and sufficient for microtubule capture downstream of ErbB2.

  13. p230, through its interaction with MACF1, provides the molecular link for transport of GPI-anchored proteins along the microtubule and actin cytoskeleton from the TGN to the cell periphery.

  14. In two lung cell lines, MACF1b was chiefly localized to the Golgi complex. The domain of MACF1b that targets it to the Golgi was found at the N-terminal part of the region that contains the plakin repeats.

  15. This protein has been found differentially expressed in the Wernicke's Area from patients with schizophrenia.

Mouse (Murine) Microtubule-Actin Crosslinking Factor 1 (MACF1) Interaktionspartner

  1. mechanical unloading decreases MACF1 expression, and MACF1 up-regulates osteoblast proliferation through enhancing beta-catenin signaling. This study has thus provided a mechanism for mechanical unloading-induced inhibited osteoblast proliferation.

  2. High fat diet and ACF7 knock-out have synergistic damaging effects on intestinal homeostasis.

  3. ablation of ACF7 inhibits intestinal wound healing and greatly increases susceptibility to experimental colitis

  4. FAK/Src-mediated phosphorylation of ACF7 is essential for F-actin binding of ACF7 and coordinated cytoskeletal dynamics at focal adhesions.

  5. These findings demonstrate a novel role for MACF1 in neurite differentiation that is critical to the creation of neuronal connectivity in the developing brain.

  6. Knockdown of MACF1 in osteoblastic cells inhibits osteoblast differentiation through suppressing the beta-catenin/TCF1-Runx2 axis.

  7. a disruption of trafficking across microtubles to actin filaments underlies the ciliogenesis defect in cells lacking MACF1.

  8. Cell counting revealed significant decrease of cell proliferation and cell cycle analysis showed an S phase cell cycle arrest in MACF1-knockdown cells.

  9. Data show that microtubule actin crosslinking factor 1 (MACF1) determines neuronal positioning by regulating microtubule dynamics and mediating glycogen synthase kinase 3 (GSK-3) signaling during brain development.

  10. data identify for the first time, a role for MACF1 in cardiomyocyte microtubule distribution and in adaptation to hemodynamic overload

  11. Studied ACF7 and paracellular permeability, by conditional knock out of ACF7 in the intestinal mucosa of mice. Findings indicated that ACF7 deficiency resulted in significant interstitial proliferation and columnar epithelial cell rearrangement.

  12. ACF7 is a linker protein that helps to shape the cytoskeleton of the hair cell during early hair-bundle genesis.

  13. Study identified a link between GSK3beta and ACF7 and further reveal the in vivo relevance of this connection in polarized locomotion of skin stem cells upon injury.

  14. Our data suggest a critical role for MACF1 in neuronal migration that is dependent on its ability to interact with both microfilaments and microtubules.

  15. In ACF7's absence, microtubules still bind EB1 and CLIP170, but they no longer grow along polarized actin bundles, nor do they pause and tether to actin-rich cortical sites.

  16. a new role of MACF1 in the Wnt signaling pathway, MACF1 was highly expressed in neuronal tissues and the foregut of embryonic day 8.5 (E8.5) embryos and the head fold and primitive streak of E7.5 embryos.

  17. ACF7 deficiency compromises the targeting of microtubules along F-actin to focal adhesions (FAs), stabilizes FA-actin networks, and impairs epidermal migration.

  18. In conclusion, LG-HMF affects osteoblast-like cell viability, MACF1 distribution, expression, and its association with cytoskeleton to some extent.

  19. Mouse ACF7 and Drosophila Short stop modulate filopodia formation and microtubule organisation during neuronal growth.

MACF1 Antigen-Profil

Beschreibung des Gens

The protein encoded by this gene belongs to the plakin family of cytoskeletal linker proteins. This protein family forms bridges between different cytoskeletal elements through specialized modular domains. The encoded protein is one of the largest size proteins identified in human cytoskeletal proteins. It has functional actin and microtubule binding domains, and it appears to stabilize actin at sites where microtubules and microfilaments meet. It may function in microtubule dynamics to facilitate actin-microtubule interactions at the cell periphery and to couple the microtubule network to cellular junctions. Alternatively spliced transcript variants encoding distinct isoforms have been described.

Genbezeichner und Symbole assoziert mit MACF1

  • microtubule-actin crosslinking factor 1 (MACF1) Antikörper
  • microtubule-actin crosslinking factor 1a (macf1a) Antikörper
  • microtubule-actin crosslinking factor 1 (macf1) Antikörper
  • microtubule-actin cross-linking factor 1 (LOC100175356) Antikörper
  • dual specificity protein kinase CLK3 (LOC100514848) Antikörper
  • microtubule-actin cross-linking factor 1, isoforms 1/2/3/5 (LOC100550622) Antikörper
  • microtubule-actin crosslinking factor 1 (Macf1) Antikörper
  • ABP620 Antikörper
  • Acf7 Antikörper
  • Aclp7 Antikörper
  • DKFZp469K2016 Antikörper
  • fc46g01 Antikörper
  • MACF Antikörper
  • MACF1 Antikörper
  • mKIAA0465 Antikörper
  • OFC4 Antikörper
  • R74989 Antikörper
  • si:rp71-45k5.7 Antikörper
  • wu:fc46g01 Antikörper

Bezeichner auf Proteinebene für MACF1

microtubule-actin crosslinking factor 1 , microfilament and actin filament cross-linker protein , actin-crosslinking protein , magellan , mgn , microtubule-actin cross-linking factor 1, isoforms 1/2/3/5 , Microtubule-actin cross-linking factor 1-like , microtubule-actin cross-linking factor 1, isoforms 1/2/3/5-like , 620 kDa actin binding protein , actin cross-linking family protein 7 , macrophin 1 , microtubule-actin cross-linking factor 1 , trabeculin-alpha , actin cross-linking family 7 , actin-crosslinking protein 7 , trabeculin alpha

GENE ID SPEZIES
419671 Gallus gallus
456778 Pan troglodytes
475321 Canis lupus familiaris
506730 Bos taurus
562190 Danio rerio
100025003 Monodelphis domestica
100068727 Equus caballus
100127846 Xenopus (Silurana) tropicalis
100173160 Pongo abelii
100175356 Ciona intestinalis
100341624 Oryctolagus cuniculus
100479117 Ailuropoda melanoleuca
100514848 Sus scrofa
100550622 Meleagris gallopavo
23499 Homo sapiens
11426 Mus musculus
362587 Rattus norvegicus
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