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we observed 3 case-specific duplications of the autosomal gene MAST2, and in a replication phase we found another 11 duplications
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Viral and PTEN peptide interactions to MAST2-PDZ occur via a unique kinetic step which involves both canonical C-terminal PBM binding and N-terminal anchoring.
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MAST2 gene rearrangements occur in invasive breast carcinoma.
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MAST205 plays an important role in regulating CFTR expression and function
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The MAST2 sequence at the 5' end of SVA(F1) acts as a positive transcriptional regulator in human germ cells.
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Overexpression of MAST1 or MAST2 gene fusions has a proliferative effect both in vitro and in vivo in breast cancer cell lines.
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Recruitment of a MAST2 CpG island was most likely beneficial to the hybrid retrotransposons because it could significantly increase retrotransposition frequency.
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Studies report the identification of a new subfamily of SVA, which apparently formed after an alternative splicing event where the first exon of the MAST2 gene spliced into an intronic SVA and subsequently retrotransposed.