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MTF1 encodes a transcription factor that induces expression of metallothioneins and other genes involved in metal homeostasis in response to heavy metals such as cadmium, zinc, copper, and silver.
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The functional characterization of a complete zebrafish MTF-1, is reported.
MTF1 is a master regulator of gene expression during development.
Findings identify a reciprocal activation mechanism involving HIF-2alpha (zeige EPAS1 ELISA Kits) and the zinc-ZIP8-MTF1 axis during osteoarthritis pathogenesis that amplifies catabolic signaling and cartilage destruction.
MTF1 mediates the increase of CaV3.2 (zeige CACNA1H ELISA Kits) mRNA and a rise in intracellular Zn(2+) which is associated with status epilepticus.
the presence of SUMO moiety allows the MTF-1 protein to interact directly with metal-responsive element
nuclear receptor SHP inhibits zinc-dependent induction of Dnmt1 (zeige DNMT1 ELISA Kits) by antagonizing metal-responsive transcription factor-1.
MTF-1 DNA-binding activity is strongly enhanced in the presence of zinc.
PTEN associates with MTF-1 in cells in response to oxidative stress and in zinc homeostasis.
Results reveal a novel repressive role for MTF-1 in the regulation of the Zip10 zinc transporter expression by pausing Pol II transcription.
Data show that disruption of nucleosome structure at the MT-I (zeige MT1 ELISA Kits) promoter is mediated by zinc-responsive recruitment of an active MTF-1-coactivator complex.
Zinc and cadmium can activate FPN1 (zeige SLC40A1 ELISA Kits) transcription through the MTF-1.
mouse MTF-1 is polymorphic
MTF1 (zeige MFI2 ELISA Kits) heads a hierarchy of zinc sensors, and through controlling the expression of a raft of metallothioneins and other key proteins involved in controlling intracellular zinc levels (e.g. ZnT1 (zeige SLC30A1 ELISA Kits)) alters zinc buffering capacity and total cellular zinc content.
MTF-1 (zeige MFI2 ELISA Kits) has a role in regulating zinc dependent cellular processes at the molecular level [review]
Forty-one single nucleotide polymorphisms (SNPs) within the MTF1 (zeige MFI2 ELISA Kits) gene region.
Human ZnT2 expression is regulated by MTF-1 (zeige MFI2 ELISA Kits).
Zn-responsive proteome profiling and time-dependent expression of proteins are regulated by MTF-1 (zeige MFI2 ELISA Kits) in human alveolar epithelial cells.
The zinc-sensing cytoplasmic transcription factor MTF-1 plays a key role in cellular zinc homoeostasis.
Results identify a cysteine cluster that mediates homodimerization of human MTF-1 (zeige MFI2 ELISA Kits), and show that dimer formation in vivo is important for basal and especially metal-induced transcriptional activity.
Variations in the ability of LAT1 (zeige LAT ELISA Kits)/DMT1/MTF1 (zeige MFI2 ELISA Kits)/MT1a (zeige MT1A ELISA Kits) to process and transport Hg may not play a significant role in the etiology of autism.
It is concluded that SUMO conjugation and the SIM on MTF-1 do not play a critical role in suppressing transcriptional activity. Instead, MTF-1 forms complexes with cellular factors through SIM and SUMO moiety in the cytoplasm
Transcriptional regulation of the beta-synuclein 5'-promoter metal response element by metal transcription factor-1.
This gene encodes a transcription factor that induces expression of metallothioneins and other genes involved in metal homeostasis in response to heavy metals such as cadmium, zinc, copper, and silver. The protein is a nucleocytoplasmic shuttling protein that accumulates in the nucleus upon heavy metal exposure and binds to promoters containing a metal-responsive element (MRE).
metal regulatory transcription factor 1
, metal-regulatory transcription factor 1
, metal regulatory transcription factor 1-like
, MRE-binding transcription factor
, metalloregulatory transcription factor
, transcription factor MTF-1
, MRE-binding transcription factor-1
, metal-responsive transcription factor 1
, zinc regulatory factor
, metal response element binding transcription factor 1