Meprin A, alpha (PABA Peptide Hydrolase) Proteine (MEP1A)

alpha subunit of meprin metalloproteases, which form homotetramers and heterodimers with beta subunit Mep1b [RGD, Feb 2006].. Zusätzlich bieten wir Ihnen Meprin A, alpha (PABA Peptide Hydrolase) Antikörper (85) und Meprin A, alpha (PABA Peptide Hydrolase) Kits (29) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
Ratte MEP1A MEP1A 25684 Q64230
MEP1A 17287 P28825
MEP1A 4224 Q16819
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Showing 8 out of 12 products:

Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Insektenzellen Maus rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Anmelden zum Anzeigen 60 bis 65 Tage
$7,506.65
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Insektenzellen Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 60 Days
$9,626.73
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Human Cells Maus His tag 10 μg Anmelden zum Anzeigen 14 bis 16 Tage
$206.80
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Escherichia coli (E. coli) Maus His tag,T7 tag 100 μg Anmelden zum Anzeigen 15 bis 18 Tage
$768.00
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Escherichia coli (E. coli) Human His tag,T7 tag 100 μg Anmelden zum Anzeigen 15 bis 18 Tage
$864.00
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Human Cells Human His tag 10 μg Anmelden zum Anzeigen 14 bis 16 Tage
$206.80
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Escherichia coli (E. coli) Human His tag   100 μg Anmelden zum Anzeigen 13 bis 16 Tage
$492.31
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Escherichia coli (E. coli) Maus Unkonjugiert   100 μg Anmelden zum Anzeigen 11 bis 18 Tage
$582.75
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MEP1A Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Mouse (Murine) , ,
, ,
Human , ,
, ,

Weitere Proteine zu Meprin A, alpha (PABA Peptide Hydrolase) (MEP1A) Interaktionspartnern

Mouse (Murine) Meprin A, alpha (PABA Peptide Hydrolase) (MEP1A) Interaktionspartner

  1. this study shows that docking of meprin alpha to heparan sulphate protects the endothelium from inflammatory cell extravasation

  2. no significant dentin malformation was observed in Mep1b (-/-) or Mep1a (-/-) deficient mice.

  3. meprin alpha and meprin beta join the modulators of Reelin signalling as they cleave Reelin at a specific site and are upregulated under specific pathological conditions.

  4. While meprin A only cleaved protein kinase A (PKA) catalytic subunit beta1, meprin B cleaved all three PKA catalytic isoforms.

  5. meprin alpha and meprin beta are unique in their ability to process and release both C- and N-propeptides from type I procollagen in vitro and in vivo

  6. the binding of S-MBP to meprins triggers the complement activation through the lectin pathway and may cause the acute renal failure due to ischemia/reperfusion injury on kidney transplantation and hemorrhagic shock

  7. Absence of meprin A aggravates chronic inflammation and lack of meprin B affords some protection from injury. Manipulation of expression of meprin gene products may have therapeutic potential.

  8. conserved sequences essential for zinc binding and enzymatic activity were determined by site-directed mutagenesis

  9. meprin-alpha may play a role in the pathogenesis of diabetic nephropathy and the benefits of ACE inhibitor therapy

  10. determined the sites of glycan attachment and assessed their ability to affect the formation and stability of the homo-oligomer

  11. Meprin A appears to be an important therapeutic target and urinary excretion appears to be a potential biomarker of acute kidney injury.

  12. meprin A, a multimeric metalloprotease expressed in the brush borders of kidney proximal tubules initially truncates mouse BNP in the N terminus to mBNP7-32

  13. Meprin A contributes to the renal and urogenital pathogenesis of endotoxicity.

  14. meprin alpha/beta null (alpha(-/-)/beta(-/-)) mice had decreased prevalence of resident monocytes and natural killer (NK) cells in blood, with a concomitant accumulation of inflammatory monocytes and NK cells in bone marrow.

  15. MEP1A is a UC susceptibility gene and indicate that decreased meprin-alpha expression is associated with intestinal inflammation in IBD patients and in a mouse experimental model of IBD.

Human Meprin A, alpha (PABA Peptide Hydrolase) (MEP1A) Interaktionspartner

  1. Mep1A is overexpressed in most hepatocellular carcinomas and induces tumor cell migration and invasion. Mep1A expression is regulated by Reptin, and Mep1A mediates Reptin-induced migration.

  2. In this review we report on recent findings that summarize the complex molecular regulation of meprins, particular folding, activation and shedding. Dysregulation of meprin alpha and meprin beta is often associated with pathological conditions such as neurodegeneration, inflammatory bowel disease and fibrosis

  3. Results showed that MEP1A expression was elevated in colorectal cancer (CRC) tissues at both the mRNA and protein levels, and provided evidence for its functionally crucial role in CRC carcinogenesis as tumor proliferation and invasion.

  4. Variants rs17468190 (G/T) in the MEP1A gene are associated with glucose and insulin metabolism in overweight/obese central European women with polycystic ovary syndrome.

  5. Meprin metalloproteases A and B inactivate interleukin 6

  6. Proteolytically active meprinalpha leads to an increase in EGFR and ERK1/2 phosphorylation and subsequently enhances cell proliferation and migration

  7. The present results indicate that a TNF-alpha-mediated down-regulation of CDX2 can be related to suppressed expression of MEP1A during intestinal inflammation.

  8. Meprin-alpha activity is regulated differently in primary tumors and metastases of colorectal cancer. By virtue of its pro-migratory and pro-angiogenic activity, meprin-alpha may promote tumor progression in colorectal cancer.

  9. Cystatin C was an inhibitor for human meprin alpha(K(i) = 8.5 x 10(-6) M) but, interestingly, not for meprin beta.

  10. meprins could be important players in several remodeling processes involving collagen fiber deposition

  11. activation in colorectal cancer triggered by the plasminogen-activating system

  12. The combination of these polymorphisms could not be found in any control individuals, suggesting that they might be involved in genetic predisposition to migraine in this family.

  13. Mephrin beta induced a dramatic change in cell morphology and reduced the cell number, indicating a function in terminal differentiation, whereas meprin alpha did not affect cell viability, and may play a role in basal keratinocyte proliferation.

  14. MEP1A is a UC susceptibility gene and indicate that decreased meprin-alpha expression is associated with intestinal inflammation in IBD patients and in a mouse experimental model of IBD.

Meprin A, alpha (PABA Peptide Hydrolase) (MEP1A) Protein Überblick

Protein Überblick

alpha subunit of meprin metalloproteases, which form homotetramers and heterodimers with beta subunit Mep1b

Genbezeichner und Symbole assoziert mit MEP1A

  • meprin A subunit alpha (Mep1a)
  • meprin 1 alpha (Mep1a)
  • meprin A subunit alpha (MEP1A)
  • AI098089 Protein
  • AW107200 Protein
  • Mep-1 Protein
  • Mep-1a Protein
  • Mep1 Protein
  • PPHA Protein

Bezeichner auf Proteinebene für MEP1A

E-24.18 , MEP-1 , endopeptidase-2 , endopeptidase-24.18 subunit alpha , meprin A alpha , meprin A subunit alpha , meprin A alpha-subunit , meprin alpha , N-benzoyl-L-tyrosyl-P-amino-benzoic acid hydrolase subunit alpha , PABA peptide hydrolase , PPH alpha , bA268F1.1 (meprin A alpha (PABA peptide hydrolase))

GENE ID SPEZIES
25684 Rattus norvegicus
17287 Mus musculus
4224 Homo sapiens
481826 Canis lupus familiaris
100154136 Sus scrofa
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