Meprin A, alpha (PABA Peptide Hydrolase) Proteine (MEP1A)

alpha subunit of meprin metalloproteases, which form homotetramers and heterodimers with beta subunit Mep1b [RGD, Feb 2006].. Zusätzlich bieten wir Ihnen Meprin A, alpha (PABA Peptide Hydrolase) Antikörper (89) und Meprin A, alpha (PABA Peptide Hydrolase) Kits (29) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
Ratte MEP1A MEP1A 25684 Q64230
MEP1A 17287 P28825
MEP1A 4224 Q16819
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Top Meprin A, alpha (PABA Peptide Hydrolase) Proteine auf antikoerper-online.de

Showing 8 out of 12 products:

Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Insektenzellen Maus rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Anmelden zum Anzeigen 60 bis 65 Tage
$7,639.51
Details
Insektenzellen Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 60 Days
$9,797.11
Details
Human Cells Maus His tag 10 μg Anmelden zum Anzeigen 20 bis 21 Tage
$206.80
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Human Cells Human His tag 10 μg Anmelden zum Anzeigen 20 bis 21 Tage
$206.80
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Escherichia coli (E. coli) Maus His tag,T7 tag 100 μg Anmelden zum Anzeigen 15 bis 18 Tage
$768.00
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Escherichia coli (E. coli) Human His tag,T7 tag 100 μg Anmelden zum Anzeigen 15 bis 18 Tage
$864.00
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Escherichia coli (E. coli) Human His tag   0.5 mg Anmelden zum Anzeigen 13 bis 16 Tage
$492.31
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Escherichia coli (E. coli) Maus Unkonjugiert   100 μg Anmelden zum Anzeigen 11 bis 18 Tage
$582.75
Details

MEP1A Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Mouse (Murine) , ,
, ,
Human , ,
, ,

Weitere Proteine zu Meprin A, alpha (PABA Peptide Hydrolase) (MEP1A) Interaktionspartnern

Mouse (Murine) Meprin A, alpha (PABA Peptide Hydrolase) (MEP1A) Interaktionspartner

  1. no significant dentin malformation was observed in Mep1b (zeige MEP1B Proteine) (-/-) or Mep1a (-/-) deficient mice.

  2. meprin alpha and meprin beta (zeige MEP1B Proteine) join the modulators of Reelin (zeige RELN Proteine) signalling as they cleave Reelin (zeige RELN Proteine) at a specific site and are upregulated under specific pathological conditions.

  3. While meprin A only cleaved protein kinase A (PKA) catalytic subunit beta1, meprin B (zeige MEP1B Proteine) cleaved all three PKA catalytic isoforms.

  4. meprin alpha and meprin beta (zeige MEP1B Proteine) are unique in their ability to process and release both C- and N-propeptides from type I procollagen (zeige COL1A2 Proteine) in vitro and in vivo

  5. the binding of S-MBP to meprins triggers the complement activation through the lectin pathway and may cause the acute renal failure due to ischemia/reperfusion injury on kidney transplantation and hemorrhagic shock

  6. Absence of meprin A aggravates chronic inflammation and lack of meprin B (zeige MEP1B Proteine) affords some protection from injury. Manipulation of expression of meprin gene products may have therapeutic potential.

  7. meprin-alpha may play a role in the pathogenesis of diabetic nephropathy and the benefits of ACE (zeige ACE Proteine) inhibitor therapy

  8. meprin A, a multimeric metalloprotease expressed in the brush borders of kidney proximal tubules initially truncates mouse BNP in the N terminus to mBNP7-32

  9. meprin alpha/beta null (alpha(-/-)/beta(-/-)) mice had decreased prevalence of resident monocytes and natural killer (NK) cells in blood, with a concomitant accumulation of inflammatory monocytes and NK cells in bone marrow.

  10. MEP1A is a UC susceptibility gene and indicate that decreased meprin-alpha expression is associated with intestinal inflammation in IBD patients and in a mouse experimental model of IBD.

Human Meprin A, alpha (PABA Peptide Hydrolase) (MEP1A) Interaktionspartner

  1. Mep1A is overexpressed in most hepatocellular carcinomas and induces tumor cell migration and invasion. Mep1A expression is regulated by Reptin (zeige RUVBL2 Proteine), and Mep1A mediates Reptin (zeige RUVBL2 Proteine)-induced migration.

  2. In this review we report on recent findings that summarize the complex molecular regulation of meprins, particular folding, activation and shedding. Dysregulation of meprin alpha and meprin beta (zeige MEP1B Proteine) is often associated with pathological conditions such as neurodegeneration, inflammatory bowel disease and fibrosis

  3. Results showed that MEP1A expression was elevated in colorectal cancer (CRC (zeige CALR Proteine)) tissues at both the mRNA and protein levels, and provided evidence for its functionally crucial role in CRC (zeige CALR Proteine) carcinogenesis as tumor proliferation and invasion.

  4. Variants rs17468190 (G/T) in the MEP1A gene are associated with glucose and insulin (zeige INS Proteine) metabolism in overweight/obese central European women with polycystic ovary syndrome.

  5. Meprin metalloproteases A and B inactivate interleukin 6 (zeige IL6 Proteine)

  6. Proteolytically active meprinalpha leads to an increase in EGFR and ERK1/2 phosphorylation and subsequently enhances cell proliferation and migration

  7. The present results indicate that a TNF-alpha (zeige TNF Proteine)-mediated down-regulation of CDX2 (zeige CDX2 Proteine) can be related to suppressed expression of MEP1A during intestinal inflammation.

  8. Meprin-alpha activity is regulated differently in primary tumors and metastases of colorectal cancer. By virtue of its pro-migratory and pro-angiogenic activity, meprin-alpha may promote tumor progression in colorectal cancer.

  9. Cystatin C (zeige CST3 Proteine) was an inhibitor for human meprin alpha(K(i) = 8.5 x 10(-6) M) but, interestingly, not for meprin beta (zeige MEP1B Proteine).

  10. activation in colorectal cancer triggered by the plasminogen (zeige PLG Proteine)-activating system

Meprin A, alpha (PABA Peptide Hydrolase) (MEP1A) Protein Überblick

Protein Überblick

alpha subunit of meprin metalloproteases, which form homotetramers and heterodimers with beta subunit Mep1b

Genbezeichner und Symbole assoziert mit MEP1A

  • meprin A subunit alpha (Mep1a)
  • meprin 1 alpha (Mep1a)
  • meprin A subunit alpha (MEP1A)
  • AI098089 Protein
  • AW107200 Protein
  • Mep-1 Protein
  • Mep-1a Protein
  • Mep1 Protein
  • PPHA Protein

Bezeichner auf Proteinebene für MEP1A

E-24.18 , MEP-1 , endopeptidase-2 , endopeptidase-24.18 subunit alpha , meprin A alpha , meprin A subunit alpha , meprin A alpha-subunit , meprin alpha , N-benzoyl-L-tyrosyl-P-amino-benzoic acid hydrolase subunit alpha , PABA peptide hydrolase , PPH alpha , bA268F1.1 (meprin A alpha (PABA peptide hydrolase))

GENE ID SPEZIES
25684 Rattus norvegicus
17287 Mus musculus
4224 Homo sapiens
481826 Canis lupus familiaris
100154136 Sus scrofa
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