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Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Zusätzlich bieten wir Ihnen MMP15 Antikörper (141) und MMP15 Proteine (10) und viele weitere Produktgruppen zu diesem Protein an.
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Although neither proteinase is required for branching morphogenesis, transcriptome profiling reveals a key role for MMP14 (zeige MMP14 ELISA Kits) and MMP15 in regulating mammary gland adipocyte differentiation. Whereas MMP14 (zeige MMP14 ELISA Kits) promotes the generation of white fat depots crucial for energy storage, MMP15 differentially controls the formation of thermogenic brown fat.
Data indicate that Snai1 (zeige SNAI1 ELISA Kits) is sufficient to promote mmp15 expression, cell transformation, and mesenchymal cell migration and invasion.
TCF-4 (zeige TCF4 ELISA Kits) is a co-activator of NF-kappaB (zeige NFKB1 ELISA Kits) p65 (zeige GORASP1 ELISA Kits) that promotes MMP-15 transcription and potentiate the migration activity of the lung cancer cells
In conclusion, MT2-MMP is involved in gastric cancer invasion and metastasis and may serve as an independent prognostic factor for gastric cancer patients.
our data suggest that MT2-MMP expression positively involves in non-small cell lung cancer and might play an important role in promoting the tumor progression and intra-tumoral angiogenesis
HLA-G (zeige HLAG ELISA Kits) expression involved in tumor invasiveness or metastasis may rely on the NK cytotoxicity inhibition and induction of MMP-15 expression in ovarian cancer.
MMP-15 is up-regulated in preeclampsia, but does not cleave endoglin (zeige ENG ELISA Kits) to produce soluble endoglin (zeige ENG ELISA Kits).
MMP-15 and MMP-19 (zeige MMP19 ELISA Kits) are upregulated during colorectal tumorigenesis
Data show that MT2-MMP was a novel hypoxia-responsive gene and was upregulated by HIF-1alpha (zeige HIF1A ELISA Kits) under hypoxia.
The intensity of immunochemical staining of MT2-MMP was significantly positively correlated to the intratumoral angiogenesis of esophageal cancer tissues.
MMP2 (zeige MMP2 ELISA Kits) activity is associated with an increase in MT2-MMP expression and with lymph node metastasis.
These results indicate MT2-MMP might be involved in the cancer progression more than or equal to MT1-MMP (zeige MMP14 ELISA Kits) independently of MMP-2 (zeige MMP2 ELISA Kits) and MT1-MMP (zeige MMP14 ELISA Kits).
Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, the protein encoded by this gene is a member of the membrane-type MMP (MT-MMP) subfamily\; each member of this subfamily contains a potential transmembrane domain suggesting that these proteins are expressed at the cell surface rather than secreted.
, MT-MMP 2
, Membrane type 2-MMP
, matrix metalloproteinase 15
, matrix metalloproteinase-15
, membrane-type matrix metalloproteinase 2
, membrane-type-2 matrix metalloproteinase
, matrix metalloproteinase 15 (membrane-inserted)