Matrix Metallopeptidase 12 (Macrophage Elastase) Proteine (MMP12)

Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Zusätzlich bieten wir Ihnen MMP12 Antikörper (201) und MMP12 Kits (75) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
MMP12 17381 P34960
MMP12 117033 Q63341
MMP12 4321 P39900
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Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 30 bis 35 Tage
$5,370.21
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Escherichia coli (E. coli) Maus His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 30 bis 35 Tage
$5,370.21
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Escherichia coli (E. coli) Kaninchen His tag 100 μg Anmelden zum Anzeigen 15 bis 18 Tage
$848.00
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Escherichia coli (E. coli) Human Unkonjugiert 100 μg Anmelden zum Anzeigen 14 bis 16 Tage
$437.80
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Escherichia coli (E. coli) Human His tag 100 μg Anmelden zum Anzeigen 11 Days
$411.40
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Human Cells Maus His tag   50 μg Anmelden zum Anzeigen 4 Days
$590.43
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Wheat germ Human GST tag 10 μg Anmelden zum Anzeigen 11 bis 12 Tage
$325.44
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Escherichia coli (E. coli) Ratte His tag 100 μg Anmelden zum Anzeigen 15 bis 18 Tage
$832.00
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Human Cells Human His tag   10 μg Anmelden zum Anzeigen 15 bis 16 Tage
$300.00
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Escherichia coli (E. coli) Human Unkonjugiert SDS-PAGE analysis of Human MMP12 Protein. 100 μg Anmelden zum Anzeigen 11 bis 18 Tage
$682.25
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MMP12 Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Mouse (Murine) ,

Rat (Rattus) ,

Human , ,
,

Weitere Proteine zu Matrix Metallopeptidase 12 (Macrophage Elastase) (MMP12) Interaktionspartnern

Mouse (Murine) Matrix Metallopeptidase 12 (Macrophage Elastase) (MMP12) Interaktionspartner

  1. MMP-12 facilitates macrophage accumulation and activation in anti-GBM glomerulonephritis which is required for glomerular crescent formation, Bowman's capsule rupture, tubular damage and renal function decline.

  2. findings define a novel physiological function of Shp2 in TGF-beta1/MMP12-dependent emphysema, adding insights into potential etiologies for this chronic lung disorder.

  3. Mmp12 is expressed early following corneal epithelial injury with highest expression levels at 8 h after injury and lower expression levels at 4 and 8 days after injury. We investigated whether MMP12 has an effect on the rate of epithelial repair and cell migration using in vivo and in vitro scratch assays performed on WT and Mmp12(-/-) mice

  4. MMP-12 produced by macrophages infiltrating into glomeruli contributed to the degradation of collagen type IV and fibronectin.

  5. MMP12 causes arterial stiffening in mice and suggest that it functions similarly in humans.

  6. These results suggest that MMP-12 production during emphysema exacerbation results in increased mortality and disease progression.

  7. study found significant increases of MMP-3 and MMP-12 mRNA levels and MMP12 zymographic activities in response to Cryptococcus neoformans infection but not C. gattii infection

  8. The results suggest that pulmonary C fiber involvement in long-term airway inflammation and airway hyperresponsiveness occurred at least partially via modulating MMP-12, and the activation of PAR2 might be related to MMP-12 production.

  9. MMP-12 up-regulation mediated by SARM-TRIF signaling pathway contributes to IFN-gamma-independent airway inflammation and AHR post RSV infection in nude mice.

  10. MMP-12 and MMP-13 alter strain K infection in mice and play a role in inflammatory regulation by modulating cytokine levels.

  11. Post-MI, MMP-12i impaired CD44-HA interactions to suppress neutrophil apoptosis and prolong inflammation, which worsened LV function.

  12. MMP12 upregulated in regenerating motor neurons of the mouse and rat facial nucleus; findings point to a role of MMP12 in the neuronal initiation of the synaptic stripping process

  13. abnormal neuronal expression of matrix metalloproteinase-12 may contribute to axonal degeneration in Niemann-Pick type C disease

  14. the results of this study show a close correlation between vascular injury markers, Arg 1+ macrophage accumulation and fibrosis and suggest an important role of MMP-12 in regulating these processes.

  15. Pik3cd inactivation leads to extracellular matrix degradation in vessels and promotes aneurysm development by inducing macrophage migration and upregulating the activator protein-1/MMP-12 pathway in macrophages.

  16. A novel systemic role for MMP12 in postnatal adipose tissue expansion and smoking-associated weight loss by suppressing vascularity within the white adipose tissue depots.

  17. Our results suggest that MMP12 released by macrophages activated on dehydrated airway surfaces may play an important role in emphysema formation in the absence of cigarette smoke exposure.

  18. Macrophage MMP12 regulates adipose tissue expansion, insulin sensitivity, and expression of inducible nitric oxide synthase.

  19. Gene expression of Mmp-12 and Mmp-13, and Timp-1 was strongly upregulated at all time points in RD compared with controls. Timp-2, Mmp-2, and Mmp-9 expression was modest.

  20. MMP12 has a protective effect on corneal fibrosis during wound repair through regulation of immune cell infiltration and angiogenesis.

Human Matrix Metallopeptidase 12 (Macrophage Elastase) (MMP12) Interaktionspartner

  1. rs3025058 in MMP3 and rs2276109 in MMP12 might not contribute to the risk of developing rheumatic heart disease in a Han population in Southern China.

  2. Studied association of matrix metallopeptidase 12 (MMP12) -82 A>G promoter single nucleotide polymorphism (SNP) with bronchial asthma in a Bulgarian population. Results suggest the variant G allele of the MMP12 -82 A>G promoter polymorphism might considered protective for development of bronchial asthma.

  3. that MMP-12 might act as a potential target for the development of novel therapeutics of esophageal squamous cell carcinoma

  4. MMP-12 (-82A/G) polymorphisms associate with obesity risk and its severity.

  5. Significant association observed for MMP-12 (-1082 A/G) (OR 2.55; 95% CI 1.75 to 3.71) gene polymorphism and risk of ischemic stroke. [meta-analysis]

  6. Review/Meta-analysis: MMP-1 -1607 1G/2G and MMP-12 -82 A/G gene polymorphisms are associated with ischemic stroke risk.

  7. The MMP12 down regulation by increasing oxygen concentration enables temporal expression control of MMP12 and involves several mechanisms including HIF-1alpha. These findings suggest MMP12 involved in trophoblast invasion during the first trimester.

  8. In the present report, hypoxia is shown to activate a HIF-KDM3A-MMP12 signaling cascade that promotes trophoblast invasion and trophoblast-directed uterine spiral artery remodeling.

  9. The current results suggest that MMP12 rs652438 but not MMP12 rs2276109 may affect the risk for Parkinson Disease

  10. The results of this study demonstrate that the gene expression of MMP9, MMP12, TIMP1 and TIMP2 was influenced by the addition of TGF-beta1. These results may be translated to chronic venous insufficiency framework and suggest involvement of TGF-beta1 in the vein wall pathology.

  11. M4 macrophages are a possible source for HDAC9 and MMP12 expression in advanced human carotid plaques.

  12. MMP12 levels were increased in gingival tissue of periodontitis patients. MMP12-producing monocyte-derived cells also had reduced CD200R surface levels. MMP12 production by these cells was induced by CSF2, and treatment with a CD200R ligand reduced CSF2-induced MMP12 production. This novel association of the CD200/CD200R pathway with MMP12 production by monocyte-derived cells may play a key role in PD progression.

  13. G allele of MMP12 -82 A > G promoter polymorphism as a protective factor for COPD in Bulgarian population

  14. Data indicate that MMP1, MMP12 and PPARG and hsa-miR-31-5p, hsa-miR-224-5p, and hsa-miR-223-3p were able to distinguish tumors from NPT with high sensitivity and specificity.

  15. Increased levels of MMP1 and MMP12 on tumor-associated macrophages in the peripheral areas of dermatofibrosarcoma protuberance might contribute to local invasion

  16. Matrix metalloprotease (MMP) regulation was the top pathway involved in gingival aging. MMP3, MMP9, MMP12, and MMP13 were upregulated in old gingival tissues, concomitantly with interleukin-1 beta (IL1B) expression.

  17. We also found that MMP12 facilitated type I collagen induced platelet aggregation, adhesion and alpha granule secretion. Similarly, one short peptide, WYKG, facilitated type I collagen induced platelet alpha granule secretion. We conclude that platelet express MMP12 may facilitate platelet activation through shedding of CEACAM1.

  18. There were no statistically significant differences in the distribution of MMP7 -181 A/G and MMP12 -82 A/G genotype, allele, or haplotype frequencies between IRSA patients and controls, as well as patients' primary and secondary idiopathic recurrent spontaneous abortion

  19. To conclude, Pseudomonas aeruginosa infection induced the expression of matrix metalloproteinases, and Pseudomonas aeruginosa type III secretion system appeared to be a key player in MMP-12 and MMP-13 expression, which is further controlled by NF-kappaB signaling.

  20. This study demonstrated that the MMP-12 levels was significantly higher in patients with atheromatous plaques than in those without plaques.

Rabbit Matrix Metallopeptidase 12 (Macrophage Elastase) (MMP12) Interaktionspartner

  1. Gene expression profiling performed on tissues obtained from pulmonary sarcoidosis patients identified MMP12 as a potential pathogenic mediator of lung damage and/or remodeling and may serve as a marker for this disease.

MMP12 Protein Überblick

Protein Überblick

Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. It is thought that the protein encoded by this gene is cleaved at both ends to yield the active enzyme, but this processing has not been fully described. The enzyme degrades soluble and insoluble elastin. It may play a role in aneurysm formation and studies in mice suggest a role in the development of emphysema. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3.

Genbezeichner und Symbole assoziert mit MMP12

  • matrix metallopeptidase 12 (MMP12)
  • matrix metallopeptidase 12 (Mmp12)
  • AV378681 Protein
  • HME Protein
  • ME Protein
  • MME Protein
  • Mmel Protein
  • MMP-12 Protein
  • MMP12 Protein

Bezeichner auf Proteinebene für MMP12

matrix metallopeptidase 12 (macrophage elastase) , matrix metalloproteinase 12 , MME , MMP-12 , macrophage elastase , macrophage metalloelastase , macrophage-metalloelastase , matrix metalloproteinase-12 , matrix metalloproteinase 12 (macrophage elastase) , macrophage metalloelastase MMP-12

GENE ID SPEZIES
451512 Pan troglodytes
17381 Mus musculus
117033 Rattus norvegicus
4321 Homo sapiens
100009559 Oryctolagus cuniculus
611789 Canis lupus familiaris
526981 Bos taurus
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