Matrix Metallopeptidase 12 (Macrophage Elastase) Proteine (MMP12)

Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Zusätzlich bieten wir Ihnen MMP12 Antikörper (199) und MMP12 Kits (76) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
MMP12 17381 P34960
MMP12 117033 Q63341
MMP12 4321 P39900
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Top MMP12 Proteine auf antikoerper-online.de

Showing 10 out of 32 products:

Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 30 bis 35 Tage
$5,465.26
Details
Escherichia coli (E. coli) Maus His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 30 bis 35 Tage
$5,465.26
Details
Escherichia coli (E. coli) Kaninchen His tag 100 μg Anmelden zum Anzeigen 15 bis 18 Tage
$848.00
Details
Escherichia coli (E. coli) Human Unkonjugiert 100 μg Anmelden zum Anzeigen 20 bis 21 Tage
$437.80
Details
Escherichia coli (E. coli) Human His tag 100 μg Anmelden zum Anzeigen 11 Days
$411.40
Details
Wheat germ Human GST tag 10 μg Anmelden zum Anzeigen 11 bis 12 Tage
$414.29
Details
Escherichia coli (E. coli) Ratte His tag 100 μg Anmelden zum Anzeigen 15 bis 18 Tage
$832.00
Details
Escherichia coli (E. coli) Human Unkonjugiert SDS-PAGE analysis of Human MMP12 Protein. 100 μg Anmelden zum Anzeigen 11 bis 18 Tage
$682.25
Details
Escherichia coli (E. coli) Maus Unkonjugiert SDS-PAGE analysis of Mouse MMP12 Protein. 100 μg Anmelden zum Anzeigen 11 bis 18 Tage
$724.89
Details
Hefe Kaninchen His tag   1 mg Anmelden zum Anzeigen 60 bis 71 Tage
$2,995.67
Details

MMP12 Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Mouse (Murine) , ,

Rat (Rattus) ,

Human , ,
,

Weitere Proteine zu Matrix Metallopeptidase 12 (Macrophage Elastase) (MMP12) Interaktionspartnern

Mouse (Murine) Matrix Metallopeptidase 12 (Macrophage Elastase) (MMP12) Interaktionspartner

  1. MMP-12 facilitates macrophage accumulation and activation in anti-GBM glomerulonephritis which is required for glomerular crescent (zeige SFRP5 Proteine) formation, Bowman's capsule rupture, tubular damage and renal function decline.

  2. findings define a novel physiological function of Shp2 (zeige PTPN11 Proteine) in TGF-beta1 (zeige TGFB1 Proteine)/MMP12-dependent emphysema, adding insights into potential etiologies for this chronic lung disorder.

  3. Mmp12 is expressed early following corneal epithelial injury with highest expression levels at 8 h after injury and lower expression levels at 4 and 8 days after injury. We investigated whether MMP12 has an effect on the rate of epithelial repair and cell migration using in vivo and in vitro scratch assays performed on WT and Mmp12(-/-) mice

  4. MMP-12 produced by macrophages infiltrating into glomeruli contributed to the degradation of collagen type IV (zeige COL4 Proteine) and fibronectin (zeige FN1 Proteine).

  5. MMP12 causes arterial stiffening in mice and suggest that it functions similarly in humans.

  6. These results suggest that MMP-12 production during emphysema exacerbation results in increased mortality and disease progression.

  7. study found significant increases of MMP-3 (zeige MMP3 Proteine) and MMP-12 mRNA levels and MMP12 zymographic activities in response to Cryptococcus neoformans infection but not C. gattii infection

  8. The results suggest that pulmonary C fiber involvement in long-term airway inflammation and airway hyperresponsiveness occurred at least partially via modulating MMP-12, and the activation of PAR2 (zeige F2RL1 Proteine) might be related to MMP-12 production.

  9. MMP-12 up-regulation mediated by SARM (zeige SARM1 Proteine)-TRIF (zeige RNF138 Proteine) signaling pathway contributes to IFN-gamma (zeige IFNG Proteine)-independent airway inflammation and AHR (zeige AHR Proteine) post RSV infection in nude mice.

  10. MMP-12 and MMP-13 (zeige MMP13 Proteine) alter strain K infection in mice and play a role in inflammatory regulation by modulating cytokine levels.

Human Matrix Metallopeptidase 12 (Macrophage Elastase) (MMP12) Interaktionspartner

  1. that MMP-12 might act as a potential target for the development of novel therapeutics of esophageal squamous cell carcinoma

  2. MMP-12 (-82A/G) polymorphisms associate with obesity risk and its severity.

  3. Significant association observed for MMP-12 (-1082 A/G) (OR 2.55; 95% CI 1.75 to 3.71) gene polymorphism and risk of ischemic stroke. [meta-analysis]

  4. Review/Meta-analysis: MMP-1 (zeige MMP1 Proteine) -1607 1G/2G and MMP-12 -82 A/G gene polymorphisms are associated with ischemic stroke risk.

  5. The MMP12 down regulation by increasing oxygen concentration enables temporal expression control of MMP12 and involves several mechanisms including HIF-1alpha (zeige HIF1A Proteine). These findings suggest MMP12 involved in trophoblast invasion during the first trimester.

  6. In the present report, hypoxia is shown to activate a HIF-KDM3A (zeige KDM3A Proteine)-MMP12 signaling cascade that promotes trophoblast invasion and trophoblast-directed uterine spiral artery remodeling.

  7. The current results suggest that MMP12 rs652438 but not MMP12 rs2276109 may affect the risk for Parkinson Disease

  8. The results of this study demonstrate that the gene expression of MMP9 (zeige MMP9 Proteine), MMP12, TIMP1 (zeige TIMP1 Proteine) and TIMP2 (zeige TIMP2 Proteine) was influenced by the addition of TGF-beta1 (zeige TGFB1 Proteine). These results may be translated to chronic venous insufficiency framework and suggest involvement of TGF-beta1 (zeige TGFB1 Proteine) in the vein wall pathology.

  9. M4 macrophages are a possible source for HDAC9 (zeige HDAC9 Proteine) and MMP12 expression in advanced human carotid plaques.

  10. MMP12 levels were increased in gingival tissue of periodontitis patients. MMP12-producing monocyte-derived cells also had reduced CD200R (zeige CD200R1 Proteine) surface levels. MMP12 production by these cells was induced by CSF2 (zeige CSF2 Proteine), and treatment with a CD200R (zeige CD200R1 Proteine) ligand reduced CSF2 (zeige CSF2 Proteine)-induced MMP12 production. This novel association of the CD200 (zeige CD200 Proteine)/CD200R (zeige CD200R1 Proteine) pathway with MMP12 production by monocyte-derived cells may play a key role in PD progression.

Rabbit Matrix Metallopeptidase 12 (Macrophage Elastase) (MMP12) Interaktionspartner

  1. Gene expression profiling performed on tissues obtained from pulmonary sarcoidosis patients identified MMP12 as a potential pathogenic mediator of lung damage and/or remodeling and may serve as a marker for this disease.

MMP12 Protein Überblick

Protein Überblick

Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. It is thought that the protein encoded by this gene is cleaved at both ends to yield the active enzyme, but this processing has not been fully described. The enzyme degrades soluble and insoluble elastin. It may play a role in aneurysm formation and studies in mice suggest a role in the development of emphysema. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3.

Genbezeichner und Symbole assoziert mit MMP12

  • matrix metallopeptidase 12 (MMP12)
  • matrix metallopeptidase 12 (Mmp12)
  • AV378681 Protein
  • HME Protein
  • ME Protein
  • MME Protein
  • Mmel Protein
  • MMP-12 Protein
  • MMP12 Protein

Bezeichner auf Proteinebene für MMP12

matrix metallopeptidase 12 (macrophage elastase) , matrix metalloproteinase 12 , MME , MMP-12 , macrophage elastase , macrophage metalloelastase , macrophage-metalloelastase , matrix metalloproteinase-12 , matrix metalloproteinase 12 (macrophage elastase) , macrophage metalloelastase MMP-12

GENE ID SPEZIES
451512 Pan troglodytes
17381 Mus musculus
117033 Rattus norvegicus
4321 Homo sapiens
100009559 Oryctolagus cuniculus
611789 Canis lupus familiaris
526981 Bos taurus
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