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Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis.
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Demedts, Morel-Montero, Lebecque, Pacheco, Cataldo, Joos, Pauwels, Brusselle: Elevated MMP-12 protein levels in induced sputum from patients with COPD. in Thorax 2006
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Margheri, Serratì, Lapucci, Chillà, Bazzichi, Bombardieri, Kahaleh, Calorini, Bianchini, Fibbi, Del Rosso: Modulation of the angiogenic phenotype of normal and systemic sclerosis endothelial cells by gain-loss of function of pentraxin 3 and matrix metalloproteinase 12. in Arthritis and rheumatism 2010
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Human MMP12 ELISA Kit für Sandwich ELISA - ABIN457032
Proietta, Tritapepe, Cifani, Ferri, Taurino, Del Porto: MMP-12 as a new marker of Stanford-A acute aortic dissection. in Annals of medicine 2014
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Mouse (Murine) MMP12 ELISA Kit für Sandwich ELISA - ABIN415783
Lenglet, Montecucco, Mach, Schaller, Gasche, Copin: Analysis of the expression of nine secreted matrix metalloproteinases and their endogenous inhibitors in the brain of mice subjected to ischaemic stroke. in Thrombosis and haemostasis 2014
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Mouse (Murine) MMP12 ELISA Kit für Sandwich ELISA - ABIN1672891
Houghton, Hartzell, Robbins, Gomis-Rüth, Shapiro: Macrophage elastase kills bacteria within murine macrophages. in Nature 2009
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Human MMP12 ELISA Kit für Sandwich ELISA - ABIN414972
Toumpanakis, Noussia, Sigala, Litsiou, Loverdos, Zacharatos, Karavana, Michailidou, Magkou, Zhou, Theocharis, Vassilakopoulos: Inspiratory resistive breathing induces MMP-9 and MMP-12 expression in the lung. in American journal of physiology. Lung cellular and molecular physiology 2015
Rat (Rattus) MMP12 ELISA Kit für Sandwich ELISA - ABIN416465
Krarup, Eld, Heinemeier, Jorgensen, Hansen, gren: Expression and inhibition of matrix metalloproteinase (MMP)-8, MMP-9 and MMP-12 in early colonic anastomotic repair. in International journal of colorectal disease 2013
findings define a novel physiological function of Shp2 (zeige PTPN11 ELISA Kits) in TGF-beta1 (zeige TGFB1 ELISA Kits)/MMP12-dependent emphysema, adding insights into potential etiologies for this chronic lung disorder.
Mmp12 is expressed early following corneal epithelial injury with highest expression levels at 8 h after injury and lower expression levels at 4 and 8 days after injury. We investigated whether MMP12 has an effect on the rate of epithelial repair and cell migration using in vivo and in vitro scratch assays performed on WT and Mmp12(-/-) mice
MMP-12 produced by macrophages infiltrating into glomeruli contributed to the degradation of collagen type IV (zeige COL4 ELISA Kits) and fibronectin (zeige FN1 ELISA Kits).
MMP12 causes arterial stiffening in mice and suggest that it functions similarly in humans.
These results suggest that MMP-12 production during emphysema exacerbation results in increased mortality and disease progression.
study found significant increases of MMP-3 (zeige MMP3 ELISA Kits) and MMP-12 mRNA levels and MMP12 zymographic activities in response to Cryptococcus neoformans infection but not C. gattii infection
The results suggest that pulmonary C fiber involvement in long-term airway inflammation and airway hyperresponsiveness occurred at least partially via modulating MMP-12, and the activation of PAR2 (zeige F2RL1 ELISA Kits) might be related to MMP-12 production.
MMP-12 up-regulation mediated by SARM-TRIF signaling pathway contributes to IFN-gamma (zeige IFNG ELISA Kits)-independent airway inflammation and AHR (zeige AHR ELISA Kits) post RSV infection in nude mice.
MMP-12 and MMP-13 (zeige MMP13 ELISA Kits) alter strain K infection in mice and play a role in inflammatory regulation by modulating cytokine levels.
Post-MI, MMP-12i impaired CD44 (zeige CD44 ELISA Kits)-HA interactions to suppress neutrophil apoptosis and prolong inflammation, which worsened LV function.
Review/Meta-analysis: MMP-1 (zeige MMP1 ELISA Kits) -1607 1G/2G and MMP-12 -82 A/G gene polymorphisms are associated with ischemic stroke risk.
The MMP12 down regulation by increasing oxygen concentration enables temporal expression control of MMP12 and involves several mechanisms including HIF-1alpha (zeige HIF1A ELISA Kits). These findings suggest MMP12 involved in trophoblast invasion during the first trimester.
In the present report, hypoxia is shown to activate a HIF-KDM3A-MMP12 signaling cascade that promotes trophoblast invasion and trophoblast-directed uterine spiral artery remodeling.
The current results suggest that MMP12 rs652438 but not MMP12 rs2276109 may affect the risk for Parkinson Disease
The results of this study demonstrate that the gene expression of MMP9 (zeige MMP9 ELISA Kits), MMP12, TIMP1 (zeige TIMP1 ELISA Kits) and TIMP2 (zeige TIMP2 ELISA Kits) was influenced by the addition of TGF-beta1 (zeige TGFB1 ELISA Kits). These results may be translated to chronic venous insufficiency framework and suggest involvement of TGF-beta1 (zeige TGFB1 ELISA Kits) in the vein wall pathology.
M4 macrophages are a possible source for HDAC9 (zeige HDAC9 ELISA Kits) and MMP12 expression in advanced human carotid plaques.
MMP12 levels were increased in gingival tissue of periodontitis patients. MMP12-producing monocyte-derived cells also had reduced CD200R (zeige CD200R1 ELISA Kits) surface levels. MMP12 production by these cells was induced by CSF2 (zeige CSF2 ELISA Kits), and treatment with a CD200R (zeige CD200R1 ELISA Kits) ligand reduced CSF2 (zeige CSF2 ELISA Kits)-induced MMP12 production. This novel association of the CD200 (zeige CD200 ELISA Kits)/CD200R (zeige CD200R1 ELISA Kits) pathway with MMP12 production by monocyte-derived cells may play a key role in PD progression.
G allele of MMP12 -82 A > G promoter polymorphism as a protective factor for COPD (zeige ARCN1 ELISA Kits) in Bulgarian population
Data indicate that MMP1 (zeige MMP1 ELISA Kits), MMP12 and PPARG (zeige PPARG ELISA Kits) and hsa (zeige CD24 ELISA Kits)-miR (zeige MLXIP ELISA Kits)-31-5p, hsa (zeige CD24 ELISA Kits)-miR (zeige MLXIP ELISA Kits)-224-5p, and hsa (zeige CD24 ELISA Kits)-miR (zeige MLXIP ELISA Kits)-223-3p were able to distinguish tumors from NPT with high sensitivity and specificity.
Increased levels of MMP1 (zeige MMP1 ELISA Kits) and MMP12 on tumor-associated macrophages in the peripheral areas of dermatofibrosarcoma protuberance might contribute to local invasion
Gene expression profiling performed on tissues obtained from pulmonary sarcoidosis patients identified MMP12 as a potential pathogenic mediator of lung damage and/or remodeling and may serve as a marker for this disease.
Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. It is thought that the protein encoded by this gene is cleaved at both ends to yield the active enzyme, but this processing has not been fully described. The enzyme degrades soluble and insoluble elastin. It may play a role in aneurysm formation and studies in mice suggest a role in the development of emphysema. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3.
matrix metallopeptidase 12 (macrophage elastase)
, matrix metalloproteinase 12
, macrophage elastase
, macrophage metalloelastase
, matrix metalloproteinase-12
, matrix metalloproteinase 12 (macrophage elastase)
, macrophage metalloelastase MMP-12