Matrix Gla Protein (MGP) ELISA Kits

Human Matrix Gla Protein (MGP) Interaktionspartner

1. Study found an association between diastolic left ventricular function with circulating inactive desphospho-uncarboxylated MGP in two cohorts; undertook histological studies confirming the presence of MGP in the heart and determining its exact localization in healthy and diseased hearts, using conformation-specific MGP antibodies.

2. Studied serum levels of bone morphogenic protein-4 (BMP-4 (zeige BMP4 ELISA Kits)) and matrix Gla protein (MGP) in patients who were admitted to emergency department with the diagnosis of acute coronary syndrome (ACS) and underwent primary percutaneous coronary intervention. MGP and BMP-4 (zeige BMP4 ELISA Kits) levels were significantly elevated when compared to subjects with normal coronary arteries.

3. genetic association studies in population in Greece: Data suggest that an SNP in promoter region of matrix Gla protein (rs1,800,802; T-138C) is associated with diabetic angiopathy (as indicated by carotid intima media thickness) in patients with type 2 diabetes and diabetic nephropathy.

4. This study concluded that diabetes coexisting with renal disease leads to extreme vascular calcification expressed by elevated MGP levels, resulting in higher frequency of cardiovascular disease in comparison to CKD patients without diabetes.

5. Increased desphospho-uncarboxylated matrix Gla protein, which is a circulating biomarker of vitamin K status and vascular calcification, is independently associated with aortic stiffness, but not with stiffness of distal muscular-type arteries.

6. Our results indicate that the association between the matrix Gla protein variant and increased risk for hand Osteoarthritis is caused by a lower expression of matrix Gla protein, which may increase the burden of hand Osteoarthritis by decreased inhibition of cartilage calcification.

7. Genetic variability in the MGP gene was associated with vascular recurrence in the Spanish population.

8. MGP is significantly repressed by miR (zeige MLXIP ELISA Kits)-155 in breast cancer MCF-7 cells, and concomitantly there is a stimulation of cell proliferation and cell invasiveness.

9. ectopic expression of Mgp in murine and human osteosarcoma cells led to a marked increase in lung metastasis. Abrogation of Mgp prevented lung metastatic activity, an effect that was rescued by forced expression. Mgp levels dramatically altered endothelial adhesion, trans-endothelial migration in vitro and tumour cell extravasation ability in vivo

10. MGP rs4236 [A/G] gene polymorphism was not to be associated with subgingival dental calculus. Also, that GCF MGP levels were detected higher in patients with subgingival dental calculus than those without subgingival dental calculus independently of polymorphism, may be the effect of adaptive mechanism to inhibit calculus formation.

Mouse (Murine) Matrix Gla Protein (MGP) Interaktionspartner

1. We propose MGP as a strong candidate for the regulation of stiffness in glaucoma. MGP further illustrates the presence of a common function affecting key glaucomatous parameters in the front and back of the eye, and thus offers the possibility for a sole therapeutic target for the disease.

2. the nasal septum to be abnormally mineralized and shortened in Mgp(-/-) mice. Transgenic restoration of Mgp expression in chondrocytes fully corrected the craniofacial anomalies caused by MGP deficiency, suggesting a local role for MGP in the developing nasal septum.

3. loss of MGP causes dysregulation of early endothelial differentiation.

4. Matrix Gla protein limits pulmonary arteriovenous malformations in ALK1 (zeige ACVRL1 ELISA Kits) deficiency.

5. expression of MGP and OCN increased gradually in the murine developing tibial epiphysis, and the two mineral-associated proteins may occur at the same location during a particular period, but at different levels.

6. Elastin (zeige ELN ELISA Kits) haploinsufficiency impedes the progression of arterial calcification in MGP-deficient mice.

7. The arterial calcification, not MGP deficiency itself, causes the low bone mass phenotype in Mgp-/- mice.

8. Two sides of MGP null arterial disease: chondrogenic lesions dependent on transglutaminase 2 (zeige TGM2 ELISA Kits) and elastin (zeige ELN ELISA Kits) fragmentation associated with induction of adipsin (zeige CFD ELISA Kits).

9. MGP is a multi-functional inhibitor of normal and abnormal angiogenesis that may function by coordinating with both Notch and BMP signaling pathways

10. Mgp gene deletion may have a role in arteriovenous malformations

Cow (Bovine) Matrix Gla Protein (MGP) Interaktionspartner

1. Selective CaSR (zeige CASR ELISA Kits) activation, either by extracellular calcium or AMG (zeige AMELX ELISA Kits) 641, increased MGP expression in vivo in the arterial wall and in vitro in bovine vascular smooth muscle cells.

2. the effect of MGP on calcification and osteogenic differentiation is determined by availability of BMP-2 (zeige BMP2 ELISA Kits)

3. MGP plays a role in endothelial cell function, by increasing transforming growth factor-beta1 activity and stimulating VEGF (zeige VEGFA ELISA Kits) expression

4. MGP has a novel binding activity for vitronectin (zeige VTN ELISA Kits)

5. Heat shock protein 70 (zeige HSP70 ELISA Kits) enhances vascular bone morphogenetic protein-4 (zeige BMP4 ELISA Kits) signaling by binding matrix Gla protein.

Xenopus laevis Matrix Gla Protein (MGP) Interaktionspartner

1. Usefulnees of nonmammalian model systems to elucidate the complex regulation of MGP gene transcription.

2. These data also indicate that MGP is under dual regulation by runx2 (zeige RUNX2 ELISA Kits) through the use of various isoforms and context-dependent formation of transcriptional complexes.

Pig (Porcine) Matrix Gla Protein (MGP) Interaktionspartner

1. High DNA methylation resulting in the down regulation of matrix Gla protein is associated with osteochondrosis.

Zebrafish Matrix Gla Protein (MGP) Interaktionspartner

1. MGP is a multi-functional inhibitor of normal and abnormal angiogenesis that may function by coordinating with both Notch and BMP signaling pathways

2. In contrast with results obtained for previously studied marine fishes, in zebrafish and Senegal sole Mgp accumulates in both calcified tissues and non-mieralized vessel walls of the vascular system.