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The protein encoded by MGP is secreted and likely acts as an inhibitor of bone formation. Zusätzlich bieten wir Ihnen Matrix Gla Protein Antikörper (66) und Matrix Gla Protein Proteine (25) und viele weitere Produktgruppen zu diesem Protein an.
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Human MGP ELISA Kit für Sandwich ELISA - ABIN414669
Louvet, Büchel, Steppan, Passlick-Deetjen, Massy: Magnesium prevents phosphate-induced calcification in human aortic vascular smooth muscle cells. in Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 2013
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Human MGP ELISA Kit für Sandwich ELISA - ABIN367214
Najafi, Roustazadeh, Amirfarhangi, Kazemi: Matrix Gla protein (MGP) promoter polymorphic variants and its serum level in stenosis of coronary artery. in Molecular biology reports 2014
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Mouse (Murine) MGP ELISA Kit für Sandwich ELISA - ABIN857742
Wang, Chen, Zhang, Yu, Zhang, Gong, Shao, Lu, Gao, Chen, Chen, Hui: Common genetic variants of MGP are associated with calcification on the arterial wall but not with calcification present in the atherosclerotic plaques. in Circulation. Cardiovascular genetics 2013
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This study concluded that diabetes coexisting with renal disease leads to extreme vascular calcification expressed by elevated MGP levels, resulting in higher frequency of cardiovascular disease in comparison to CKD patients without diabetes.
Increased desphospho-uncarboxylated matrix Gla protein, which is a circulating biomarker of vitamin K status and vascular calcification, is independently associated with aortic stiffness, but not with stiffness of distal muscular-type arteries.
Our results indicate that the association between the matrix Gla protein variant and increased risk for hand Osteoarthritis is caused by a lower expression of matrix Gla protein, which may increase the burden of hand Osteoarthritis by decreased inhibition of cartilage calcification.
Genetic variability in the MGP gene was associated with vascular recurrence in the Spanish population.
MGP is significantly repressed by miR (zeige MLXIP ELISA Kits)-155 in breast cancer MCF-7 cells, and concomitantly there is a stimulation of cell proliferation and cell invasiveness.
ectopic expression of Mgp in murine and human osteosarcoma cells led to a marked increase in lung metastasis. Abrogation of Mgp prevented lung metastatic activity, an effect that was rescued by forced expression. Mgp levels dramatically altered endothelial adhesion, trans-endothelial migration in vitro and tumour cell extravasation ability in vivo
MGP rs4236 [A/G] gene polymorphism was not to be associated with subgingival dental calculus. Also, that GCF MGP levels were detected higher in patients with subgingival dental calculus than those without subgingival dental calculus independently of polymorphism, may be the effect of adaptive mechanism to inhibit calculus formation.
The substitution of threonine by alanine due to MGP exon 4 Thr83Ala polymorphism is related to a decrease in the likelihood of arterial calcification in female persons in the Ukrainian population
Correlations of plasma desphosphorylated uncarboxylated matrix Gla protein (dp-ucMGP) with vascular calcification and vascular stiffness in chronic kidney disease. Plasma dp-ucMGP was positively associated with vascular calcification and might be utilized as an early marker for vascular calcification in CKD patients.
It is assumed that Lp-PLA2 (zeige Lp-PLA2 ELISA Kits) is involved in vascular calcification and that dp-ucMGP is a more appropriate biomarker of residual risk than Lp-PLA2 (zeige Lp-PLA2 ELISA Kits) itself.
We propose MGP as a strong candidate for the regulation of stiffness in glaucoma. MGP further illustrates the presence of a common function affecting key glaucomatous parameters in the front and back of the eye, and thus offers the possibility for a sole therapeutic target for the disease.
the nasal septum to be abnormally mineralized and shortened in Mgp(-/-) mice. Transgenic restoration of Mgp expression in chondrocytes fully corrected the craniofacial anomalies caused by MGP deficiency, suggesting a local role for MGP in the developing nasal septum.
loss of MGP causes dysregulation of early endothelial differentiation.
Matrix Gla protein limits pulmonary arteriovenous malformations in ALK1 (zeige ACVRL1 ELISA Kits) deficiency.
expression of MGP and OCN increased gradually in the murine developing tibial epiphysis, and the two mineral-associated proteins may occur at the same location during a particular period, but at different levels.
Elastin (zeige ELN ELISA Kits) haploinsufficiency impedes the progression of arterial calcification in MGP-deficient mice.
The arterial calcification, not MGP deficiency itself, causes the low bone mass phenotype in Mgp-/- mice.
Two sides of MGP null arterial disease: chondrogenic lesions dependent on transglutaminase 2 (zeige TGM2 ELISA Kits) and elastin (zeige ELN ELISA Kits) fragmentation associated with induction of adipsin (zeige CFD ELISA Kits).
MGP is a multi-functional inhibitor of normal and abnormal angiogenesis that may function by coordinating with both Notch and BMP signaling pathways
Mgp gene deletion may have a role in arteriovenous malformations
Selective CaSR (zeige CASR ELISA Kits) activation, either by extracellular calcium or AMG (zeige AMELX ELISA Kits) 641, increased MGP expression in vivo in the arterial wall and in vitro in bovine vascular smooth muscle cells.
the effect of MGP on calcification and osteogenic differentiation is determined by availability of BMP-2 (zeige BMP2 ELISA Kits)
MGP plays a role in endothelial cell function, by increasing transforming growth factor-beta1 activity and stimulating VEGF (zeige VEGFA ELISA Kits) expression
MGP has a novel binding activity for vitronectin (zeige VTN ELISA Kits)
Heat shock protein 70 (zeige HSP70 ELISA Kits) enhances vascular bone morphogenetic protein-4 (zeige BMP4 ELISA Kits) signaling by binding matrix Gla protein.
Usefulnees of nonmammalian model systems to elucidate the complex regulation of MGP gene transcription.
These data also indicate that MGP is under dual regulation by runx2 (zeige RUNX2 ELISA Kits) through the use of various isoforms and context-dependent formation of transcriptional complexes.
High DNA methylation resulting in the down regulation of matrix Gla protein is associated with osteochondrosis.
In contrast with results obtained for previously studied marine fishes, in zebrafish and Senegal sole Mgp accumulates in both calcified tissues and non-mieralized vessel walls of the vascular system.
The protein encoded by this gene is secreted and likely acts as an inhibitor of bone formation. The encoded protein is found in the organic matrix of bone and cartilage. Defects in this gene are a cause of Keutel syndrome (KS). Two transcript variants encoding different isoforms have been found for this gene.
cell growth-inhibiting gene 36 protein
, matrix gamma-carboxyglutamate (gla) protein
, matrix Gla protein
, Matrix Gla protein