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The protein encoded by MST1 contains four kringle domains and a serine protease domain, similar to that found in hepatic growth factor. Zusätzlich bieten wir Ihnen MST1 Kits (48) und MST1 Proteine (17) und viele weitere Produktgruppen zu diesem Protein an.
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Human Polyclonal MST1 Primary Antibody für IHC (p), WB - ABIN392427
Ren, Yan, You, Sun: Down-regulation of mammalian sterile 20-like kinase 1 by heat shock protein 70 mediates cisplatin resistance in prostate cancer cells. in Cancer research 2008
Show all 2 Pubmed References
hWW45 (zeige SAV1 Antikörper) is required to enhance MST1-mediated apoptosis in vivo and thus is a critical player in an MST1-driven cell death signaling pathway.
MST1-FOXO1 (zeige FOXO1 Antikörper) signaling is an important link survival factor deprivation-induced neuronal cell death
hSav1 is a newly identified protein that interacts with Mst1 and augments Mst1-mediated apoptosis.
tolerance to increased levels of intracellular ROS (zeige ROS1 Antikörper) provided by the Mst1-FoxOs signaling pathway is crucial for the maintenance of naive T cell homeostasis in the periphery
The identified Mst1 as a binding partner that interacts with PHLPPs both in vivo and in vitro. PHLPPs dephosphorylate Mst1 on the T387 inhibitory site, which activate Mst1 and its downstream effectors p38 (zeige CRK Antikörper) and JNK (zeige MAPK8 Antikörper) to induce apoptosis.
H2AX (zeige H2AFX Antikörper) is a substrate of MST1, which functions to induce apoptotic chromatin condensation and DNA fragmentation
novel regulatory mechanism involving the phosphorylation of Sirt1 (zeige SIRT1 Antikörper) by MST1 kinase which leads to p53 (zeige TP53 Antikörper) activation, with implications for our understanding of signaling mechanisms during DNA damage-induced apoptosis
Mst1 exhibits a growth promoting activity (zeige CNTF Antikörper) in HCC (zeige FAM126A Antikörper) cells upon NORE1B (zeige RASSF5 Antikörper) downregulation.
Mst1 inactivates Prdx1 (zeige PRDX1 Antikörper) by phosphorylating it at Thr (zeige TRH Antikörper)-90 and Thr (zeige TRH Antikörper)-183, leading to accumulation of hydrogen peroxide in cells.
Mst1 has an important role in inhibiting the growth of NSCLC in vitro and in vivo; its antiproliferative effect is associated with induction of apoptosis.
The results suggest that melatonin alleviates cardiac remodeling and dysfunction in diabetic cardiomyopathy by upregulating autophagy, limiting apoptosis, and modulating mitochondrial integrity and biogenesis. The mechanisms are associated with Mst1/Sirt3 (zeige SIRT3 Antikörper) signaling.
These data suggest that MSP is an effective inhibitor of inflammation and lipid accumulation in the stressed liver, thereby indicating that MSP has a key regulatory role in non-alcoholic steatohepatitis.
kinases, including Slk (zeige SLK Antikörper), Lok and Mst1, are inhibited by BI-D1870 but to a much lesser extent by BIX 02565 and that phosphorylation of some of their substrates is blocked by BI-D1870 in living cells.
Nicorandil alleviates post-MI cardiac dysfunction and remodeling. The mechanisms were associated with enhancing autophagy and inhibiting apoptosis through Mst1 inhibition.
Using a standard two-thirds partial hepatectomy (PH) model in young and aged mice, the activity of the core kinases MST1 and LATS1 increased during the early hypertrophic phase and returned to steady state levels in the proliferative phase, coinciding with activation of YAP1 (zeige YAP1 Antikörper) target genes and hepatocyte proliferation.
The MST1 acts as a molecular brake to maintain immune tolerance by regulating T cell-mediated B cell activation (zeige BLNK Antikörper).
Mst1 knockout alleviated while Mst1 overexpression aggravated cardiac dysfunction in diabetes.
these findings highlight a role for MST1 in vesicle trafficking and extravasation in neutrophils, providing an additional mechanistic explanation for the severe immune defect
Results identify L-plastin (zeige LCP1 Antikörper) as a key effector of Mst1 and establish a novel mechanism linking a signaling intermediate to an actin-binding protein (zeige PFN1 Antikörper) critical to T cell migration.
MIST1 is a scaling factor necessary and sufficient by itself to induce and maintain secretory cell architecture
The protein encoded by this gene contains four kringle domains and a serine protease domain, similar to that found in hepatic growth factor. Despite the presence of the serine protease domain, the encoded protein may not have any proteolytic activity. The receptor for this protein is RON tyrosine kinase, which upon activation stimulates ciliary motility of ciliated epithelial lung cells. This protein is secreted and cleaved to form an alpha chain and a beta chain bridged by disulfide bonds.
, STE20-like kinase MST1
, dJ211D12.2 (serine/threonine kinase 4 (MST1, KRS2))
, kinase responsive to stress 2
, mammalian STE20-like protein kinase 1
, mammalian sterile 20-like 1
, serine/threonine-protein kinase 4
, serine/threonine-protein kinase Krs-2
, hepatocyte growth factor-like protein
, hepatocyte growth factor-like protein homolog
, macrophage-stimulating protein
, E2F transcription factor 2
, macrophage stimulatory protein
, hepatocyte growth factor-like/macrophage stimulating protein
, macrophage stimulating 1 (hepatocyte growth factor-like)
, 12S E1A
, macrophage stimulating 1 L homeolog