anti-MDS1 and EVI1 Complex Locus (MECOM) Antikörper

Core binding factor (CBF) is a heterodimeric transcription factor that binds to the core element of many enhancers and promoters. Zusätzlich bieten wir Ihnen MDS1 and EVI1 Complex Locus Proteine (8) und MDS1 and EVI1 Complex Locus Kits (2) und viele weitere Produktgruppen zu diesem Protein an.

Alle Antikörper anzeigen Gen GeneID UniProt
MECOM 2122 Q03112 , Q13465
MECOM 14013 Q9Z1L8
MECOM 294924  
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Top anti-MDS1 and EVI1 Complex Locus Antikörper auf antikoerper-online.de

Showing 10 out of 115 products:

Katalog Nr. Reaktivität Wirt Konjugat Applikation Bilder Menge Anbieter Lieferzeit Preis Details
Rind (Kuh) Kaninchen Unkonjugiert IHC, WB Host: Rabbit Target Name: EVI1 Sample Tissue: Human 293T Antibody Dilution: 1.0ug/ml Host: Rabbit Target Name: MECOM Sample Tissue: Human 293T Whole Cell Antibody Dilution: 1ug/ml 100 μL Anmelden zum Anzeigen 2 bis 3 Tage
$289.00
Details
Rind (Kuh) Kaninchen Unkonjugiert WB <b>WB Suggested Anti-EVI1 Antibody Titration: </b>0.2-1 ug/ml<br><b>ELISA Titer: </b>1:62500<br><b>Positive Control: </b>Hela cell lysate 100 μL Anmelden zum Anzeigen 2 bis 3 Tage
$289.00
Details
Human Kaninchen Unkonjugiert WB WB Suggested Anti-EVI1 Antibody Titration: 0.2-1 ug/ml ELISA Titer: 1:1562500 Positive Control: Human brain 100 μL Anmelden zum Anzeigen 2 bis 3 Tage
$289.00
Details
Human Kaninchen Unkonjugiert WB <b>WB Suggested Anti-MDS1 Antibody Titration: </b>1.25ug/ml<br><b>ELISA Titer: </b>1:312500<br><b>Positive Control: </b>Raji cell lysate WB Suggested Anti-MDS1 <br /> Antibody Titration: 1.25 µg/mL ELISA Titer: 1:312500 <br /> Positive Control: Raji cell lysate 100 μL Anmelden zum Anzeigen 2 bis 3 Tage
$229.00
Details
Human Ziege Unkonjugiert ELISA, WB 0.1 mg Anmelden zum Anzeigen 2 bis 3 Tage
$481.25
Details
Human Ziege Unkonjugiert ELISA, WB Western Blot: EVI1 Antibody [NBP1-68842] - Analysis of EVI1 in A549 lysate (35ug protein in RIPA buffer) using NBP1-68842 at 2ug/ml. Primary incubation was 1 hour. Detected by chemiluminescence. 0.1 mg Anmelden zum Anzeigen 7 bis 9 Tage
$485.88
Details
Human Kaninchen Unkonjugiert EIA, WB Western blot analysis of EVI1 Antibody (N-term) in CEM cell line lysates (35ug/lane). This demonstrates the EVI1 antibody detected the EVI1 protein (arrow). 0.4 mL Anmelden zum Anzeigen 6 bis 8 Tage
$390.50
Details
Human Kaninchen Unkonjugiert EIA, WB Western blot analysis of MDS1 Antibody (Center) in mouse NIH-3T3 cell line lysates (35ug/lane). This demonstrates the MDS1 antibody detected the MDS1 protein (arrow). 0.4 mL Anmelden zum Anzeigen 6 bis 8 Tage
$390.50
Details
Human Maus Unkonjugiert WB Western analysis of extracts from 293 cells using PRDM3 antibody. 400 μL Anmelden zum Anzeigen 10 bis 11 Tage
$324.50
Details
Human Maus Unkonjugiert EIA, WB 0.4 mL Anmelden zum Anzeigen 6 bis 8 Tage
$390.50
Details

MECOM Antikörper nach Reaktivität, Anwendung, Klonalität and Konjugat

Attribute Applikationen Wirt Klonalität Konjugat
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Rat (Rattus)


Am meisten referenzierte anti-MDS1 and EVI1 Complex Locus Antikörper

  1. Human Polyclonal MECOM Primary Antibody für ELISA, WB - ABIN4270672 : Konrad, Karger, Hackl, Schwarzinger, Herbacek, Wieser: Inducible expression of EVI1 in human myeloid cells causes phenotypes consistent with its role in myelodysplastic syndromes. in Journal of leukocyte biology 2009 (PubMed)

Weitere Antikörper gegen MDS1 and EVI1 Complex Locus Interaktionspartner

Human MDS1 and EVI1 Complex Locus (MECOM) Interaktionspartner

  1. Fisher's exact SubID was used to reveal EVI1 as a transcriptional regulator of INPP4B (zeige INPP4B Antikörper) in AML (zeige RUNX1 Antikörper); a finding which was validated in vitro. Next, we used CoxPH SubID to conduct a pan (zeige SUPT6H Antikörper)-cancer analysis of INPP4B's prognostic significance

  2. Letter/Case Report: ETV6 (zeige ETV6 Antikörper)/MECOM gene fusion in therapy-related acute myeloid leukemia (zeige BCL11A Antikörper) with t(3;12) and monosomy 7.

  3. These findings highlight a novel mechanism for hepatitis B virus X-induced hepatocarcinogenesis through transcription factor EVI1 and its target lncRNAs

  4. Findings represent the first global genome-wide study of EVI1 DNA binding associated with whole transcriptome expression analysis. Results reveal several important genes with an ETS (zeige ETS1 Antikörper)-like binding motif, is involved in terminal myeloid differentiation, cell cycle regulation and apoptosis

  5. The expression of EVI1 and SOX9 (zeige SOX9 Antikörper) is associated with stem cell-like and metastasis signatures, and their depletion impairs the metastatic potential of breast cancer cells. These results establish the mechanistic link between resistance to mTOR (zeige FRAP1 Antikörper) inhibition and cancer metastatic potential, thus enhancing our understanding of mTOR (zeige FRAP1 Antikörper) targeting failure

  6. EVI1 contributes to PCa (zeige FLVCR1 Antikörper) progression by regulating different oncogenic functions. EVI1 regulates the PCa (zeige FLVCR1 Antikörper) stem cell compartment responsible for disease initiation and also development of CRPC.

  7. oncogenic potential for EVI1 in modulating genomic stability

  8. EVI1 acts as a regulator of its own expression, highlighting the complex regulation of EVI1, and open new directions to better understand the mechanisms of EVI1 overexpressing leukemias.

  9. EVI1 overexpression alters cellular metabolism. EVI1 promotes CKMT1 (zeige CKMT1B Antikörper) expression by repressing the myeloid differentiation regulator RUNX1 (zeige RUNX1 Antikörper).

  10. EVI1 transcription is directly regulated by LEF1 (zeige LEF1 Antikörper)/beta-catenin (zeige CTNNB1 Antikörper) complex in myeloid blast crisis of chronic myeloid leukemia (zeige BCL11A Antikörper). Loss of p53 (zeige TP53 Antikörper) function as a key regulator for beta-catenin (zeige CTNNB1 Antikörper)-EVI1 in myeloid blast crisis of chronic myeloid leukemia (zeige BCL11A Antikörper).

Mouse (Murine) MDS1 and EVI1 Complex Locus (MECOM) Interaktionspartner

  1. These findings highlight a novel mechanism for hepatitis B virus X-induced hepatocarcinogenesis through transcription factor EVI1 and its target lncRNAs

  2. Gata2 (zeige GATA2 Antikörper) heterozygous deletion confers selective advantage to EVI1-expressing leukemia cell expansion in recipient mice

  3. EVI1 acts as a regulator of its own expression, highlighting the complex regulation of EVI1, and open new directions to better understand the mechanisms of EVI1 overexpressing leukemias.

  4. the DNA sequences to which EVI1 binds at +35 and +37 kb and show that mutation of one of these releases Cebpa (zeige CEBPA Antikörper) from EVI1-induced suppression.

  5. Evi1(+)DA-3 cells modified to express an intracellular form of GM-CSF (zeige CSF2 Antikörper), acquired growth factor independence and transplantability and caused an overt leukemia in syngeneic hosts, without increasing serum GM-CSF (zeige CSF2 Antikörper) levels.

  6. Survivin (zeige BIRC5 Antikörper) partially regulates HSC (zeige FUT1 Antikörper) function by modulating the Evi-1 transcription factor and its downstream targets

  7. Thrombopoietin (zeige THPO Antikörper)/MPL (zeige MPL Antikörper) signaling confers growth and survival capacity to CD41-positive cells in a mouse model of Evi1 leukemia.

  8. Prdm16 (zeige PRDM16 Antikörper) and Prdm3 control postnatal BAT (zeige BAAT Antikörper) identity and function.

  9. Mice carrying a hypomorphic Evi1 allele are embryonic viable but exhibit severe congenital heart defects.

  10. PR-domain protein ME has an essential role in mixed-lineage leukemia (MLL (zeige MLL Antikörper)) fusion protein (MFP) leukemia

Zebrafish MDS1 and EVI1 Complex Locus (MECOM) Interaktionspartner

  1. nephrogenesis in zebrafish is regulated by interactions between retinoic acid, mecom, and Notch (zeige NOTCH1 Antikörper) signaling

  2. Prdm3 and prdm16 (zeige PRDM16 Antikörper) are strongly expressed in the pharyngeal arches during cranioskeletal development, and their knockdown leads to defects in both the viscerocranium and the neurocranium.

Xenopus laevis MDS1 and EVI1 Complex Locus (MECOM) Interaktionspartner

  1. Evi-1 (zeige RUNX1 Antikörper) is detected by in situ hybridization in the pronephric tissue, the brain and in neural crest derivatives of the head and neck

MDS1 and EVI1 Complex Locus (MECOM) Antigen-Profil

Protein Überblick

The protein encoded by this gene is a transcriptional regulator and oncoprotein that may be involved in hematopoiesis, apoptosis, development, and cell differentiation and proliferation. The encoded protein can interact with CTBP1, SMAD3, CREBBP, KAT2B, MAPK8, and MAPK9. This gene can undergo translocation with the AML1 gene, resulting in overexpression of this gene and the onset of leukemia. Several transcript variants encoding a few different isoforms have been found for this gene.

Genbezeichner und Symbole assoziert mit MECOM

  • MDS1 and EVI1 complex locus (MECOM) Antikörper
  • MDS1 and EVI1 complex locus (Mecom) Antikörper
  • MDS1 and EVI1 complex locus (mecom) Antikörper
  • MDS1 and EVI1 complex locus L homeolog (mecom.L) Antikörper
  • AML1-EVI-1 Antikörper
  • D630039M04Rik Antikörper
  • evi-1 Antikörper
  • evi1 Antikörper
  • im:7140716 Antikörper
  • Jbo Antikörper
  • Mds Antikörper
  • Mds1 Antikörper
  • Mds1-Evi1 Antikörper
  • mecom Antikörper
  • mecom-a Antikörper
  • mecom-b Antikörper
  • prdm3 Antikörper
  • xEvi-1 Antikörper
  • Znfpr1b1 Antikörper

Bezeichner auf Proteinebene für MECOM

AML1-EVI-1 fusion protein , MDS1 and EVI1 complex locus protein EVI1 , MDS1 and EVI1 complex locus protein MDS1 , ecotropic virus integration site 1 protein homolog , myelodysplasia syndrome-associated protein 1 , oncogene EVI1 , zinc finger protein Evi1 , ecotropic viral integration site 1 , ecotropic virus integration site 1 protein , myelodysplasia syndrome 1 homolog , myelodysplasia syndrome 1 protein homolog , PR domain containing 3 , MDS1 and EVI1 complex locus , MDS1 and EVI1 complex locus protein EVI1-like , MDS1 and EVI1 complex locus protein EVI1-A , ecotropic virus integration site 1 protein homolog-A , myelodysplasia syndrome 1-ectopic viral integration site 1

GENE ID SPEZIES
2122 Homo sapiens
424997 Gallus gallus
532209 Bos taurus
14013 Mus musculus
497407 Danio rerio
460837 Pan troglodytes
488148 Canis lupus familiaris
698603 Macaca mulatta
100343228 Oryctolagus cuniculus
100403987 Callithrix jacchus
100591579 Nomascus leucogenys
294924 Rattus norvegicus
734157 Xenopus laevis
Ausgewählte Anbieter für anti-MDS1 and EVI1 Complex Locus (MECOM) Antikörper
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